Results 221 to 230 of about 159,317 (346)

Single‐Cell RNA Sequencing Delineates Renal Anti‐Fibrotic Mechanisms Mediated by TRPC6 Inhibition

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals how TRPC6 inhibition alters renal cell composition and gene expression in CKD. The study uncovers a novel endothelial subpopulation (ECRIN), highlights key inflammatory and fibrotic pathways, and identifies a Prnp‐driven network linked to fibrosis resolution, offering mechanistic insight into TRPC6 as a potential ...
Yao Xu, Zhihuang Zheng, Marleen Silke Oswald, Guozhe Cheng, Jun Liu, Qidi Zhai, Ute Kruegel, Michael Schaefer, Holger Gerhardt, Nicole Endlich, Maik Gollasch, Stefan Simm, Dmitry Tsvetkov   +12 more
wiley   +1 more source

Tumor-infiltrating lymphocytes as predictive biomarkers in neoadjuvant treatment of HER2-positive breast cancer. [PDF]

Oncologist
Kınıkoğlu O, Altıntaş YE, Yıldız A, Akdağ G, Bal H, Yaşar ZY, Özkerim U, Yıldız HŞ, Öksüz S, Tünbekici S, Doğan A, Işık D, Yaşar A, Başoğlu T, Sürmeli H, Odabaş H, Turan N.   +16 more
europepmc   +1 more source

TAP expression reduces IL-10 expressing tumor infiltrating lymphocytes and restores immunosurveillance against melanoma [PDF]

, 2007
Qian‐Jin Zhang, Robyn P. Seipp, Susan S. Chen, Timothy Z. Vitalis, Xiaolin Li, Kyung‐Bok Choi, Andrew P. Jeffries, Wilfred A. Jefferies   +7 more
openalex   +1 more source

A unique cellular and molecular microenvironment is present in tertiary lymphoid organs of patients with spontaneous prostate cancer regression [PDF]

, 2017
de la Luz Garcia-Hernandez, Maria, Espinosa-Gonzalez, Ricardo, Kast, W. Martin, Khader, Shabaana A, Rangel-Moreno, Javier, Uribe-Uribe, Norma Ofelia   +5 more
core   +2 more sources

NDRG1‐Driven Lactate Accumulation Promotes Lung Adenocarcinoma Progression Through the Induction of an Immunosuppressive Microenvironment

Advanced Science, EarlyView.
NDRG1 drives lactate accumulation and histone lactylation in lung adenocarcinoma, promoting immunosuppression via M2 macrophage polarization and CD8⁺ T cell inhibition. High NDRG1 expression correlates with poor prognosis, an immunosuppressive microenvironment, and immunotherapy resistance.
Gujie Wu, Hongxia Cheng, Jiacheng Yin, Yuansheng Zheng, Haochun Shi, Binyang Pan, Ming Li, Mengnan Zhao, Jiaqi Liang, Yunyi Bian, Guangyao Shan, Guoshu Bi, Weigang Guo, Lin Wang, Yiwei Huang   +14 more
wiley   +1 more source

Prognostic impact of tumor-infiltrating lymphocytes in HER2+ metastatic breast cancer receiving first-line treatment. [PDF]

NPJ Breast Cancer
Taurelli Salimbeni B, Giudici F, Pescia C, Berton Giachetti PPM, Scafetta R, Zagami P, Marra A, Trapani D, Esposito A, Scagnoli S, Cerbelli B, Botticelli A, Munzone E, Fusco N, Criscitiello C, Curigliano G.   +15 more
europepmc   +1 more source

Lack of Effector Cell Function and Altered Tetramer Binding of Tumor-Infiltrating Lymphocytes

, 2002
Ulrike Blohm, Evelyn Roth, Kathrin Brommer, Tilman Dumrese, Felicia M. Rosenthal, Hanspeter Pircher   +5 more
openalex   +1 more source

Post‐Translational Modified Neoantigens in Autoimmune Diseases: Challenges of Immune Tolerance

Advanced Science, EarlyView.
Autoimmune diseases have a high incidence and disability rate. The pathogenesis of autoimmune diseases involves the interaction among genetic factors, environmental factors, and immune disorders. The post‐translational modified neoantigens are the key nodal of these three factors. And these post‐translational modified neoantigens, after being presented
Yue Zhai, Kefei Wu, Qi Lin, Zhenzhen Cao, Yankun Jia, Ping Zhu   +5 more
wiley   +1 more source

918 Functional heterogeneity of CD4+ tumor-infiltrating lymphocytes

Journal for ImmunoTherapy of Cancer, 2023
Marco Donia, Mads H Andersen, Martin Lauss, Göran Jönsson, Arianna Draghi, Katja Harbst, Inge Svane, Torben Lorentzen, Shawez Khan, Mario Presti, Christopher A Chamberlain, Agnete WP Jensen, Michael D Crowther, Anne-Christine K Rasmussen, Benedetta Albieri   +14 more
doaj   +1 more source

Pathologist-Read vs AI-Driven Assessment of Tumor-Infiltrating Lymphocytes in Melanoma.

JAMA Netw Open
Aung TN, Liu M, Su D, Shafi S, Boyaci C, Steen S, Tsiknakis N, Vidal JM, Maher N, Micevic G, Tan SX, Vesely MD, Nourmohammadi S, Bai Y, Djureinovic D, Wong PF, Bates K, Chan NNN, Gavirelatou N, He M, Burela S, Barna R, Bosic M, Bräutigam K, Illabochaca I, Chenhao Z, Gama J, Kreis B, Mohacsi R, Pillar N, Pinto J, Poulios C, Toli MA, Tzoras E, Bracero Y, Bosisio F, Cserni G, Dema A, Fortarezza F, Gonzalez MS, Gullo I, Queipo Gutiérrez FJ, Hacihasanoglu E, Jovic V, Lazar B, Olinca M, Neppl C, Oliveira RC, Pezzuto F, Gomes Pinto D, Plotar V, Pop O, Rau T, Skok K, Sun W, Serbes ED, Solass W, Stanowska O, Szasz M, Szymonski K, Thimm F, Vignati D, Vigdorovits A, Prieto V, Sinnberg T, Wilmott J, Cowper S, Warrell J, Saenger Y, Hartman J, Plummer J, Osman I, Rimm DL, Acs B.   +73 more
europepmc   +1 more source