Results 241 to 250 of about 337,127 (342)

918 Functional heterogeneity of CD4+ tumor-infiltrating lymphocytes

Journal for ImmunoTherapy of Cancer, 2023
Marco Donia, Mads H Andersen, Martin Lauss, Göran Jönsson, Arianna Draghi, Katja Harbst, Inge Svane, Torben Lorentzen, Shawez Khan, Mario Presti, Christopher A Chamberlain, Agnete WP Jensen, Michael D Crowther, Anne-Christine K Rasmussen, Benedetta Albieri   +14 more
doaj   +1 more source

Correlation between recognition of autologous tumor organoids by tumor-infiltrating lymphocytes from metastatic epithelial cancers and clinical response. [PDF]

J Immunother Cancer
Gustafson AM, Bhasin A, Gasmi B, Bui BD, Ade CM, Hanada KI, Halas HK, Gartner JJ, Prickett TD, Salazar J, Parkhust MR, Robbins P, Klemen ND, Kwong ML, Goff SL, Rosenberg SA, Yang JC.   +16 more
europepmc   +1 more source

Targeting WDR12 Unleashes T‐Cell‐Mediated Antitumor Activity in Melanoma by Destabilizing CD276

Advanced Science, EarlyView.
WDR12 cooperates with the chaperonin subunit CCT7 to maintain CD276 stability on tumor cells, suppressing T‐cell activity and promoting immune escape. SU14813, a small‐molecule WDR12 inhibitor, reduces CD276 stability and relieves CD276‐mediated T‐cell suppression.
Jie Pan, Ruimin Chang, Meng Zhang, Qian Dong, Guanxiong Zhang, Xiang Chen, Mingliang Chen, Lixia Lu, Xiaowei Liang, Yeye Guo, Juan Su   +10 more
wiley   +1 more source

Liver Metastasectomy to Obtain Tumor-Infiltrating Lymphocytes: Technical Considerations and Report on Single-Center Experience. [PDF]

Ann Surg Oncol
Kenney LM, Dinerman AJ, Gustafson AM, Hakim AA, Goff SL, Kwong MLM, Kammula US, Hernandez JM, Yang JC, Rosenberg SA, Klemen ND.   +10 more
europepmc   +1 more source

Eye‐Brain Neuroimmune Axis Enables Long‐Term Survival in Glioblastoma by Modulating Brain Immune Surveillance and Neuronal Excitability

Advanced Science, EarlyView.
The eye–brain neuroimmune axis triggers immune activation and disrupts pathological neuronal connectivity to extend glioblastoma survival. ABSTRACT As an anatomical extension of the central nervous system (CNS), the eye harbors rich neural and immune interfaces with the brain. However, the integrated immunological and neurological nexus between the eye
Mingyue Cui, Lulu Qian, Binbin Chu, Xuan Qin, Menglin Wu, Minke Wu, Tongyu He, Baochuan Zhang, Bin Song, Yao He   +9 more
wiley   +1 more source

AI-driven spatial analysis of tumor-infiltrating lymphocytes predicts chemo-immunotherapy response in triple-negative breast cancer. [PDF]

Front Immunol
Liang H, Zhu H, Wang L, Yu J, Feng R, Yan X, Shi L, Xiao J, Zhou H, Chen P, Liu H, Zheng L.   +11 more
europepmc   +1 more source

Nano‐Confined Radical Anion as An NIR‐II Photothermal Immunogenic Amplifier for In Situ Cancer Vaccination

Advanced Science, EarlyView.
A nano‐confined radical anion acts as a photothermal immunogenic amplifier. Kinetically stabilized nanoparticles couple high near‐infrared‐II (NIR‐II) photothermal efficacy with glutathione (GSH) depletion to boost reactive oxygen species (ROS) and immunogenic cell death (ICD).
Mengxin Mu, Mengyu Guo, Jun Guan, Xiaofeng He, Mingdi Hu, Fene Gao, Klaus Müllen, Chendong Ji, Chunying Chen, Meizhen Yin   +9 more
wiley   +1 more source

Potent Cytotoxic Tumor-Infiltrating Lymphocytes Can Be Generated from Immune-Excluded Chondrosarcomas Using Regulatable Membrane-Bound IL15. [PDF]

Cancer Immunol Res
Ao Z, Al-Marayaty R, Aksoy BA, Obeidin F, Burga R, Attar S, Peabody T, Hermida de Viveiros P, Kei Ng JC, Jing W, Shinglot H, Zhang A, Ocando AV, Roy N, Kulkarni G, Alvarado A, Sun D, Sethi DK, Ols M, Ter Meulen J, Pollack SM.   +20 more
europepmc   +1 more source

Targeting the ATX‐LPA Axis Overcomes TKI Resistance and Immunosuppression in Renal Cell Carcinoma via Dual Inhibition of AKT/mTOR and TBK1/IRF3 Pathways

Advanced Science, EarlyView.
ABSTRACT Background Therapeutic resistance limits durable survival in advanced/metastatic renal cell carcinoma (RCC) treated with first‐line tyrosine kinase inhibitor (TKI) plus immune checkpoint inhibitor (ICI). We sought to define key resistance drivers and actionable targets.
Jinchen Luo, Hansen Lin, Haoqian Feng, Lei Tan, Xi Liu, Yong Huang, Junjie Cen, Jiajie Chen, Xinwei Zhou, Mingjie Lin, Wuyuan Liao, Zheyu Ai, Minyu Chen, Yinghan Wang, Wei Chen, Junhang Luo, Yanping Liang   +16 more
wiley   +1 more source

Estrogen receptor α expression in tumor-infiltrating lymphocytes from patients with endometrial cancer. [PDF]

Oncol Lett
Jedryka MA, Slawek A, Kubik P, Lorek D, Kedzierska AE, Czekanski A, Matkowski R, Chelmonska-Soyta A.   +7 more
europepmc   +1 more source