Advances and prospects in tumor infiltrating lymphocyte therapy [PDF]
Discover OncologyTumor-infiltrating lymphocyte (TIL) therapy in adoptive T-cell therapy (ACT) has already caused durable regression in a variety of cancer types due to T-cell persistence, clinical activity, and duration of objective response and safety. TILs are composed
Xu Qiu +7 more
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Research progress on tumor-infiltrating lymphocyte therapy for cervical cancer [PDF]
Frontiers in ImmunologyCervical cancer is a common malignant tumor in women, and human papillomavirus (HPV) infection is a major cause of cervical cancer. Tumor-infiltrating lymphocytes (TILs) are a heterogeneous group of lymphocytes primarily composed of T lymphocytes found ...
Wei Zhang +9 more
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Modeling ex vivo tumor-infiltrating lymphocyte expansion from established solid malignancies
OncoImmunology, 2021 Adoptive transfer of tumor-infiltrating lymphocytes (TIL) elicits the regression of metastatic malignancies, yet a low proportion of patients achieve complete durable responses.
Hannah M Knochelmann +14 more
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Neighborhood clustering analysis to define epithelial–stromal interface for tumor infiltrating lymphocyte evaluation [PDF]
Journal of Pathology InformaticsEvaluation of tumor infiltrating lymphocytes as recommended by current guidelines is largely based on stromal regions within the tumor. In the context of epithelial malignancies, the epithelial region and the epithelial–stromal interface are not assessed,
Tony Yeung +3 more
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Tumor‐infiltrating lymphocyte therapy and the mucosal melanoma treatment landscape [PDF]
Cancer CommunicationsJennifer Thomas +3 more
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Significance of tumor-associated neutrophils, lymphocytes, and neutrophil-to-lymphocyte ratio in non-invasive and invasive bladder urothelial carcinoma [PDF]
Journal of Pathology and Translational Medicine, 2023 Background Tumor-infiltrating neutrophils and lymphocytes play essential roles in promoting or combating various neoplasms. This study aimed to investigate the association between tumor-infiltrating neutrophils and lymphocytes and the neutrophil-to ...
Wael Abdo Hassan +5 more
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Tumor Infiltrating Lymphocytes in Ovarian Cancer [PDF]
Asian Pacific Journal of Cancer Prevention, 2015 Several improvements in ovarian cancer treatment have been achieved in recent years, both in surgery and in combination chemotherapy with targeting. However, ovarian tumors remain the women's cancers with highest mortality rates. In this scenario, a pivotal role has been endorsed to the immunological environment and to the immunological mechanisms ...
GASPARRI, MARIALUISA +8 more
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Tumor Infiltrating Lymphocyte Expression of PD-1 Predicts Response to Anti-PD-1/PD-L1 Immunotherapy [PDF]
Journal of Immunotherapy and Precision Oncology, 2022 Introduction: Many studies have focused on the role of programmed death receptor ligand 1 (PD-L1) expression in predicting immunotherapy outcomes. Limited clinical data are available regarding the role of programmed death receptor 1 (PD-1; the PD-L1 ...
Nicholas J. Bevins +5 more
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Tumor-Infiltrating Lymphocytes in Melanoma [PDF]
Current Oncology Reports, 2012 Adoptive cell therapy using tumor-infiltrating lymphocytes (TIL) is arguably the most effective treatment for patients with metastatic melanoma. With higher response rates than ipilimumab or IL-2, and longer durations of response than vemurafenib, TIL therapy carries the potential to transform current outcomes in melanoma, while also defining the way ...
Sylvia, Lee, Kim, Margolin
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Evaluation of tumor infiltrating lymphocytes in breast carcinomas
Journal of Pathology of Nepal, 2022 Background: Among the parameters that have a prognostic and/or predictive significance to therapeutic response, in the case of breast carcinoma, the study of tumor-infiltrating lymphocytes in breast carcinomas is emerging.
Shovana Karki +2 more
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