Tumor-infiltrating lymphocytes in the immunotherapy era [PDF]
Cellular & Molecular Immunology, 2020 The clinical success of cancer immune checkpoint blockade (ICB) has refocused attention on tumor-infiltrating lymphocytes (TILs) across cancer types. The outcome of immune checkpoint inhibitor therapy in cancer patients has been linked to the quality and magnitude of T cell, NK cell, and more recently, B cell responses within the tumor microenvironment.
Sterre T, Paijens +3 more
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Prognostic value of inflammatory and immune markers in resectable colorectal cancer [PDF]
Zhongguo aizheng zazhi, 2021 Colorectal cancer is one of the most common malignant tumors in the world. The incidence and mortality of colorectal cancer are increasing year by year in China, and the trend of younger age is becoming more and more obvious.
MA Yifei , LIANG Xinjun , WEI Shaozhong
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, 2023 Tumor-infiltrating lymphocytes (TILs) are vital elements of the tumor microenvironment (TME), and the anti-tumor activity of TILs on colorectal cancer (CRC) has been a topic of concern.
Miao Qin (724772) +11 more
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The role of tumor-infiltrating lymphocytes in cholangiocarcinoma
Journal of Experimental & Clinical Cancer Research, 2022 AbstractCholangiocarcinoma (CCA) is the second most common primary liver cancer and associated with a dismal prognosis due to the lack of an efficient systemic therapy. In contrast to other cancers, new immunotherapies have demonstrated unsatisfactory results in clinical trials, underlining the importance of a deeper understanding of the special tumor ...
Dong Liu +8 more
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Engineering the tumor microenvironment of colorectal cancer [PDF]
, 2014 The tumor microenvironment contributes significantly to the clinical prognosis, especially in CRC. Infiltration by cells from the adaptive immune system (e.g. CD8) has been linked to a better survival independently of TNM-stage.
Hirt, Christian Kurt
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T-cell metagene predicts a favorable prognosis in estrogen receptor-negative and HER2-positive breast cancers [PDF]
, 2009 Introduction: Lymphocyte infiltration (LI) is often seen in breast cancer but its importance remains controversial. A positive correlation of human epidermal growth factor receptor 2 (HER2) amplification and LI has been described, which was associated ...
Pusztai, Laos +14 more
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The biologic importance of tumor‐infiltrating lymphocytes [PDF]
Journal of Cutaneous Pathology, 2010 Detailed pathologic analysis has delineated a close association between intratumoral CD 8+ cytotoxic T cells and favorable clinical outcomes in diverse cancers. Conversely, the presence at tumor sites of negative immune regulatory elements, such as FoxP 3+ T cells (Tregs) and PD‐1/PD‐L1 co‐stimulatory molecules, is closely associated with inferior ...
F Stephen, Hodi, Glenn, Dranoff
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Role of tumor architecture in elicitation of effector functions of human cytotoxic T-lymphocytes recognizing melanoma associated antigens [PDF]
, 2006 Growth in 3D architectures has been shown to promote the resistance of cancers to treatment with drugs, cytokines, or irradiation, thereby potentially playing an important role in tumor expansion.
Ghosh, Sourabh
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Targeting Potential of Innate Lymphoid Cells in Melanoma and Other Cancers
Pharmaceutics, 2023 Reinvigorating the killing function of tumor-infiltrating immune cells through the targeting of regulatory molecules expressed on lymphocytes has markedly improved the prognosis of cancer patients, particularly in melanoma.
Hobin Seo +5 more
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T lymphocytes from patients with primary biliary cirrhosis produce reduced amounts of lymphotoxin, tumor necrosis factor and interferon-gamma upon mitogen stimulation [PDF]
, 1992 Primary biliary cirrhosis (PBC) is considered an autoimmune disease characterized by destruction of small intrahepatic bile ducts by lymphocytes. Altered functions of these lymphocytes might reflect an abnormal immune response leading to tissue damage ...
Eisenburg, Josef +9 more
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