Results 31 to 40 of about 93,268 (298)

Oncolytic adenovirus shapes the ovarian tumor microenvironment for potent tumor-infiltrating lymphocyte tumor reactivity

Journal for ImmunoTherapy of Cancer, 2020
Background Ovarian cancers often contain significant numbers of tumor-infiltrating lymphocytes (TILs) that can be readily harnessed for adoptive T-cell therapy (ACT).
Akseli Hemminki, Víctor Cervera-Carrascón, Mikko Siurala, Riikka Havunen, Sadia Zafar, Tanja de Gruijl, Anna Kanerva, João Manuel Santos, Camilla Heiniö, Dafne C A Quixabeira, Ralf Butzow, Heini Lassus   +11 more
doaj   +1 more source

Breast cancer in Tanzanian, black American, and white American women: An assessment of prognostic and predictive features, including tumor infiltrating lymphocytes.

PLoS ONE, 2019
IntroductionBreast cancer is a major cause of morbidity and mortality for women in Sub-Saharan Africa and for black American women. There is evidence that the pathologic characteristics of breast cancers in both African women and black American women may
Alex Mremi, Gloria Broadwater, Kahima Jackson, Patrick Amsi, Cosmas Mbulwa, Terry Hyslop, Cecilia Ong, Allison Hall   +7 more
doaj   +1 more source

The expression of programmed death 1 in tumor-infiltrating lymphocytes of hepatocellular carcinoma and its correlation with prognosis

Zhongguo aizheng zazhi, 2021
Background and purpose: Programmed death 1 (PD-1) plays an important role in the regulation of peripheral immune tolerance. The expression of PD-1 in tumor-infiltrating lymphocytes of hepatocellular carcinoma (HCC) and the relationship between PD-1 ...
肖　锋, 肖静文, 邵建国, 陈丽燕, 顾春燕   +4 more
doaj  

IAP inhibitor, Embelin increases VCAM-1 levels on the endothelium, producing lymphocytic infiltration and antitumor immunity

OncoImmunology, 2020
There is an increasing unmet need for successful immunotherapeutic interventions. Lymphocyte extravasation via tumor tissue endothelial cells (TECs) is required for lymphocyte infiltration into tumor sites.
Kosei Nakajima, Yoshinori Ino, Rie Yamazaki-Itoh, Chie Naito, Mari Shimasaki, Mami Takahashi, Minoru Esaki, Satoshi Nara, Yoji Kishi, Kazuaki Shimada, Nobuyoshi Hiraoka   +10 more
doaj   +1 more source

Progression on the Roles and Mechanisms of Tumor-Infiltrating T Lymphocytes in Patients With Hepatocellular Carcinoma

Frontiers in Immunology, 2021
Primary liver cancer (PLC) is one of the most common malignancies in China, where it ranks second in mortality and fifth in morbidity. Currently, liver transplantation, hepatic tumor resection, radiofrequency ablation, and molecular-targeted agents are ...
Xiaoqin Zheng, Wenjie Jin, Wenjie Jin, Shanshan Wang, Huiguo Ding   +4 more
doaj   +1 more source

Escape from immunotherapy: possible mechanisms that influence tumor regression/progression [PDF]

, 2004
Tumor escape is one major obstacle that has to be addressed prior to designing and delivering successful immunotherapy. There is compelling evidence to support the notion that immunogenic tumors, in murine models and cancer patients, can be rejected by ...
Ahmad, M, Ali, SA, Rees, RC
core   +1 more source

Lifileucel, a Tumor-Infiltrating Lymphocyte Therapy, in Metastatic Melanoma

, 2021
Effective treatment options are limited for patients with advanced (metastatic or unresectable) melanoma who progress after immune checkpoint inhibitors and targeted therapies.
Khushalani, NI, Chesney, Jason A., Thomas, SS, Shi, Wen, Whitman, Eric D., Martin-Algarra, S, Oláh, J, Sarnaik, Amod A, Graf Finckenstein, F, Kluger, HM, Chesney, JA, Kirkwood, John M., Takamura, Toshimi, Chesney, Jason A, Domingo-Musibay, Evidio, Curti, Brendan D., Wu, Xiao, Jagasia, Madan, Lewis, KD, Fardis, Maria, Medina, Theresa, Larkin, James M G, Kirkwood, JM, Lutzky, J, Larkin, James M. G., Shi, W, Pavlick, Anna C., Curti, Brendan D, Corrie, Pippa, Sarnaik, Amod A., Oláh, Judit, Whitman, Eric D, Whitman, ED, Martin-Algarra, Salvador, Takamura, T, Hamid, Omid, Domingo-Musibay, E, Kirkwood, John M, Chartier, Cecile, Wu, X, Lutzky, Jose, Weber, Jeffrey S, Lewis, Karl D, Weber, Jeffrey S., Chartier, C, Corrie, P, Pavlick, Anna C, Kluger, Harriet M, Hamid, O, Pavlick, AC, Curti, BD, Qin, H, Khushalani, Nikhil I., Fardis, M, Khushalani, Nikhil I, Thomas, Sajeve S, Jagasia, M, Weber, JS, Kluger, Harriet M., Medina, T, Larkin, JMG, Graf Finckenstein, Friedrich, Thomas, Sajeve S., Qin, Harry, Sarnaik, AA, Lewis, Karl D.   +65 more
core   +2 more sources

Tumor-infiltrating γδ T lymphocytes: pathogenic role, clinical significance and differential programming in the tumor microenvironment.

Frontiers in Immunology, 2014
There is increasing clinical evidence indicating that the immune system may either promote or inhibit tumor progression. Several studies have demonstrated that tumors undergoing remission are largely infiltrated by T lymphocytes (tumor-infiltrating ...
Elena eLo Presti, Francesco eDieli, Serena eMeraviglia   +2 more
doaj   +1 more source

ASSESSMENT OF STROMAL AND INTRA-EPITHELIAL TUMOR INFILTRATING LYMPHOCYTES IN COLORECTAL CARCINOMA AT ARMED FORCES INSTITUTE OF PATHOLOGY

Pakistan Armed Forces Medical Journal, 2021
Objective: To conduct a morphological evaluation quantitatively of two types of tumor-infiltrating lymphocyte populations, including those located in the stroma and intraepithelial cancer structures, in patients with colorectal cancer.
Amna Ameer, Farhan Akhtar, Hafeez Ud Din, Rabia Ahmed   +3 more
doaj   +1 more source

AI-based tumor-infiltrating lymphocyte scoring system for assessing HCC prognosis in patients undergoing liver resection [PDF]

JHEP Reports
Xiangtian Zhao, Anant Madabhushi, Cheng Lu   +2 more
exaly   +2 more sources