Results 251 to 260 of about 159,317 (346)

Targeting both tumour-associated CXCR2+ neutrophils and CCR2+ macrophages disrupts myeloid recruitment and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma [PDF]

, 2018
Belt, Brian A, Cullinan, Darren R, DeNardo, David G, Fields, Ryan C, Gillanders, William E, Goedegebuure, Peter, Han, Booyeon J, Hawkins, William G, Jacobs, Ryan C, Linehan, David C, Nywening, Timothy M, Panni, Roheena Z, Patel, Ankit A, Sanford, Dominic E, Ye, Jian   +14 more
core   +1 more source

Editorial: Emerging Concepts on the NKG2D Receptor-Ligand Axis in Health and Diseases. [PDF]

, 2020
Guerra, Nadia, Lanier, Lewis L
core  

Advanced Cancer Immunotherapy via SMARCAL1 Blockade Using a Glucose‐Responsive CRISPR Nanovaccine

Advanced Science, EarlyView.
A glucose‐catalyzed chemodynamic strategy is proposed to activate therapeutic genome editing of SMARCAL1to improve cancer immunotherapy. This innovative design featuring Fenton reaction activity and glucose consumption ability, not only effectively synergizes to activate the cGAS‐STING pathway but also inhibits the opposing functions of interferon by ...
Yuwei Li, Yuanyi Zhang, Chenchen Li, Guoping Chen, Pir Muhammad, Yonghong Yao, Lifang Gao, Zhigang Liu, Yanli Wang   +8 more
wiley   +1 more source

Different MRI-based radiomics machine learning models to predict CD3+ tumor-infiltrating lymphocytes in rectal cancer. [PDF]

Front Oncol
Ma W, Hou C, Yang M, Wei Y, Mao J, Guan L, Zhao Z.   +6 more
europepmc   +1 more source

HLA‐DR⁺ Tumor Cells Show an Association with a Distinct Immune Microenvironment and CD8⁺ T‐Cell Exhaustion in HBV‐Associated Hepatocellular Carcinoma

Advanced Science, EarlyView.
This study integrates scRNA‐seq, multiplex immunofluorescence, and clinical data to identify HLA‐DR⁺tumor cells uniquely enriched in Hepatocellular carcinoma (HCC) with hepatitis B virus (HBV). These cells express MHC II, associate with PD‐L1, recruit and exhaust CD8⁺T cells, predict poor survival, and serve as potential biomarkers for immunotherapy ...
Jun‐Qing Chang, Yan Guo, Wen‐Jing Yuan, Yu‐Man Chen, Bo‐Wei Liu, Wen‐Tao Li, Xiang‐Ming Ding, Xu‐Dong Fu, Yu‐Han Lou, Zhuo‐Ran Chen, Xiao‐Ying Luo, Song‐Ze Ding, Bing‐Yong Zhang, Xiu‐Ling Li, Yong‐Zhi Hong, Shun‐Dong Cang, Dong‐Xiao Li, Ling Lan   +17 more
wiley   +1 more source

The expression of epidermal growth factor receptor 2 and its relationship with tumor-infiltrating lymphocytes and clinical pathological features in breast cancer patients. [PDF]

Open Life Sci
Li Y, Tang H, Yang X, Men N.
europepmc   +1 more source

Mitochondrial Regulation of CD8⁺ T Cells: Mechanisms and Therapeutic Modulation

Advanced Science, EarlyView.
This article comprehensively explores the pivotal role of mitochondrial function in CD8⁺ T cell immunotherapy. It highlights how mitochondrial dynamics regulate T cell activation, differentiation, and persistence, and how mitochondrial dysfunction leads to immune exhaustion and impaired antitumor/antiviral responses.
Xu Chen, Pei Lin, Ye Lu, Jiarong Zheng, Yunfan Lin, Zihao Zhou, Li Cui, Xinyuan Zhao   +7 more
wiley   +1 more source

Tumor-Infiltrating Lymphocytes and Neutrophils and Their Location in Canine Mammary Neoplasms with a Solid Arrangement: A Prognostic Factor? [PDF]

Animals (Basel)
Flecher MC, Reys MP, Balabram D, Nakagaki KYR, Cassali GD.   +4 more
europepmc   +1 more source

Gene Transfer of Tumor-Reactive TCR Confers Both High Avidity and Tumor Reactivity to Nonreactive Peripheral Blood Mononuclear Cells and Tumor-Infiltrating Lymphocytes

, 2006
Laura A. Johnson, Bianca Heemskerk, Daniel J. Powell, Cyrille J. Cohen, Richard A. Morgan, Mark E. Dudley, Paul F. Robbins, Steven A. Rosenberg   +7 more
openalex   +1 more source

Cryogel‐Based Dendritic Cell Immunotherapy for Post‐Surgical Breast Cancer Treatment

Advanced Science, EarlyView.
A multifunctional GelMA cryogel enables dendritic cell immunotherapy that synergizes with doxorubicin and PD‐1 blockade, driving robust post‐surgical T‐cell immunity and suppressing TNBC recurrence. Abstract Triple‐negative breast cancer (TNBC) is an aggressive malignancy with high mortality and limited treatment options.
Lam‐Duc‐Huy Nguyen, Sheng‐Liang Cheng, Yu‐Ting Yen, Hsin‐Mei Lee, Te‐Haw Wu, Jane Wang, Shu‐Yi Lin, Yunching Chen   +7 more
wiley   +1 more source