Results 41 to 50 of about 135,956 (230)
Vascularized Tumor-on-a-Chip Model as a Platform for Studying Tumor-Microenvironment-Drug Interaction. [PDF]
Macromol BiosciABSTRACTAs cancer‐targeting technologies advance, robust platforms for evaluating drug delivery systems (DDS) under pathomimetic conditions are critically needed. Traditional models inadequately mimic human tumor microenvironment (TME) complexity due to interspecies variance, structural simplification, and static perfusion. Vascularized tumor‐on‐a‐chip
Kim H, Cho SW, Kim HN.
europepmc +3 more sources
Tumor-on-a-chip: a microfluidic model to study cell response to environmental gradients. [PDF]
Lab Chip, 2019 Limited blood supply and rapid tumor metabolism within solid tumors leads to nutrient starvation, waste product accumulation and the generation of pH gradients across the tumor mass.
Ayuso JM +9 more
europepmc +4 more sources
Three-Dimensional In Vitro Lymphangiogenesis Model in Tumor Microenvironment
Frontiers in Bioengineering and Biotechnology, 2021 Lymphangiogenesis is a stage of new lymphatic vessel formation in development and pathology, such as inflammation and tumor metastasis. Physiologically relevant models of lymphatic vessels have been in demand because studies on lymphatic vessels are ...
Youngkyu Cho +9 more
doaj +1 more source
An in vitro model of cancer invasion with heterogeneous ECM created with droplet microfluidics
Frontiers in Bioengineering and Biotechnology, 2023 Metastasis is a multi-step process that is critically affected by cues from the tumor micro-environment (TME), such as from the extracellular matrix (ECM). The role of the ECM in the onset of metastasis, invasion, is not yet fully understood.
Mohammad Jouybar +10 more
doaj +1 more source
Study on Development of Composite Hydrogels With Tunable Structures and Properties for Tumor-on-a-Chip Research. [PDF]
Front Bioeng Biotechnol, 2020 A major factor for developing new tumor models is to recreate a proper three-dimensional environment for 3D tumors culture. In this 3D microenvironment, extracellular matrices play important roles in regulation of hallmark features of cancer through biochemical and mechanical signals.
Chen Z +10 more
europepmc +5 more sources
Metastasis in context: modeling the tumor microenvironment with cancer-on-a-chip approaches
Disease Models & Mechanisms, 2018 Most cancer deaths are not caused by the primary tumor, but by secondary tumors formed through metastasis, a complex and poorly understood process.
Jelle J. F. Sleeboom +4 more
doaj +1 more source
Tumor-on-a-chip platforms to study cancer–immune system crosstalk in the era of immunotherapy
Lab on a Chip, 2021 Immunotherapy is a powerful therapeutic approach able to re-educate the immune system to fight cancer. In this scenario, tumor-on-chip can help to choose the right immunotherapeutic treatment.
Parlato S. +5 more
openaire +2 more sources
3D cancer models: One step closer to in vitro human studies
Frontiers in Immunology, 2023 Cancer immunotherapy is the great breakthrough in cancer treatment as it displayed prolonged progression-free survival over conventional therapies, yet, to date, in only a minority of patients.
Nicoletta Manduca +5 more
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Frontiers in Oncology, 2023 Even though breast cancers usually have a good outcome compared to other tumors, the cancer can progress and create metastases in different parts of the organism, the bone being a predilection locus.
Anaïs Lamouline +9 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2020 Glioblastoma (GBM) is the most common and devastating primary brain tumor, leading to a uniform fatality after diagnosis. A major difficulty in eradicating GBM is the presence of microscopic residual infiltrating disease remaining after multimodality ...
Henry Ruiz-Garcia +6 more
doaj +1 more source