An Advanced 3D Model of Vascularized Epithelial Ovarian Cancer in a Tumor-on-a-Chip System Based on Multi-Cell Culture [PDF]
SensorsEpithelial ovarian cancer (EOC) is a highly lethal malignancy characterized by significant heterogeneity and poor prognosis due to late-stage diagnosis and chemotherapy resistance.
Magdalena Flont +7 more
doaj +2 more sources
Cell Reports, 2018 Summary: A major challenge in cancer research is the complexity of the tumor microenvironment, which includes the host immunological setting. Inspired by the emerging technology of organ-on-chip, we achieved 3D co-cultures in microfluidic devices ...
Marie Nguyen +22 more
doaj +3 more sources
Spatiotemporal dissection of tumor microenvironment via in situ sensing and monitoring in tumor-on-a-chip [PDF]
Biosensors and Bioelectronics, 2023 Lang Zhou, Weiqiang Chen, Pengyu Chen
exaly +2 more sources
Tumor-on-a-chip: from bioinspired design to biomedical application. [PDF]
Microsyst Nanoeng, 2021 AbstractCancer is one of the leading causes of human death, despite enormous efforts to explore cancer biology and develop anticancer therapies. The main challenges in cancer research are establishing an efficient tumor microenvironment in vitro and exploring efficient means for screening anticancer drugs to reveal the nature of cancer and develop ...
Liu X +9 more
europepmc +5 more sources
3D Biomimetic Models to Reconstitute Tumor Microenvironment In Vitro: Spheroids, Organoids, and Tumor‐on‐a‐Chip [PDF]
Advanced Healthcare Materials, 2023 Mengsu Yang, Xinyuan Guan
exaly +2 more sources
From Spheroids to Tumor-on-a-Chip for Cancer Modeling and Therapeutic Testing. [PDF]
Micromachines (Basel)The high failure rate of anticancer drugs in clinical trials highlights the need for preclinical models that accurately reproduce the structural, biochemical, and mechanical complexity of human tumors. Conventional two-dimensional cultures and animal models often lack the physiological complexity required to predict clinical outcomes, driving the ...
Lipreri MV +3 more
europepmc +5 more sources
Magnetic hyperthermia therapy in glioblastoma tumor on-a-Chip model. [PDF]
Einstein (Sao Paulo), 2020 To evaluate the magnetic hyperthermia therapy in glioblastoma tumor-on-a-Chip model using a microfluidics device.The magnetic nanoparticles coated with aminosilane were used for the therapy of magnetic hyperthermia, being evaluated the specific absorption rate of the magnetic nanoparticles at 300 Gauss and 305kHz. A preculture of C6 cells was performed
Mamani JB +8 more
europepmc +7 more sources
Biofabrication approaches and regulatory framework of metastatic tumor-on-a-chip models for precision oncology. [PDF]
Med Res Rev, 2022 AbstractThe complexity of the tumor microenvironment (TME) together with the development of the metastatic process are the main reasons for the failure of conventional anticancer treatment. In recent years, there is an increasing need to advance toward advanced in vitro models of cancer mimicking TME and simulating metastasis to understand the ...
Nieto D +5 more
europepmc +5 more sources
Microfluidic Tumor-on-a-Chip Model to Study Tumor Metabolic Vulnerability. [PDF]
Int J Mol Sci, 2020 Tumor-specific metabolic adaptations offer an interesting therapeutic opportunity to selectively destroy cancer cells. However, solid tumors also present gradients of nutrients and waste products across the tumor mass, forcing tumor cells to adapt their metabolism depending on nutrient availability in the surrounding microenvironment.
Ayuso JM +6 more
europepmc +4 more sources
Micromachines, 2021 Glioma, as an aggressive type of cancer, accounts for virtually 80% of malignant brain tumors. Despite advances in therapeutic approaches, the long-term survival of glioma patients is poor (it is usually fatal within 12–14 months).
Merve Ustun +4 more
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