Results 201 to 210 of about 135,956 (230)
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Advances in 3D Vascularized Tumor-on-a-Chip Technology
2022Tumors disrupt the normal homeostasis of human body as they proliferate in abnormal speed. For constant proliferation, tumors recruit new blood vessels transporting nutrients and oxygen. Immune system simultaneously recruits lymphatic vessels to induce the death of tumor cells. Hence, understanding tumor dynamics are important to developing anti-cancer
Sangmin, Jung +3 more
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The design basis and application in urology of the tumor-on-a-chip platform
Urologic Oncology: Seminars and Original Investigations, 2022Clinical research has been desperately looking for effective treatments for tumors. As the molecular mechanisms of tumors have not been thoroughly defined, and the problem of anti-tumor drug resistance and clinical drug screening are not effective, new ways are currently needed to explore and improve.
Fei Sheng, Rui-peng Jia
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Tumor‐On‐A‐Chip Models for Predicting In Vivo Nanoparticle Behavior
SmallAbstractNanosized drug formulations are broadly explored for the improvement of cancer therapy. Prediction of in vivo nanoparticle (NP) behavior, however, is challenging, given the complexity of the tumor and its microenvironment. Microfluidic tumor‐on‐a‐chip models are gaining popularity for the in vitro testing of nanoparticle targeting under ...
Wouter Verdurmen, Roland Brock
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Ex Vivo Evaluation of Combination Immunotherapy Using Tumor‐Microenvironment‐on‐Chip
Advanced Healthcare Materials, 2023AbstractCombination immunotherapy has emerged as a promising strategy to address the challenges associated with immune checkpoint inhibitor (ICI) therapy in breast cancer. The efficacy of combination immunotherapy hinges upon the intricate and dynamic nature of the tumor microenvironment (TME), characterized by cellular heterogeneity and molecular ...
Hsuan‐Yu Mu +13 more
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Tumor-on-a-chip platforms for assessing nanoparticle-based cancer therapy
Nanotechnology, 2018Cancer has become the most prevalent cause of deaths, placing a huge economic and healthcare burden worldwide. Nanoparticles (NPs), as a key component of nanomedicine, provide alternative options for promoting the efficacy of cancer therapy. Current conventional cancer models have limitations in predicting the effects of various cancer treatments.
Yimin Wang +5 more
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Channel-assembling tumor microenvironment on-chip for evaluating anticancer drug efficacy
Journal of Controlled ReleaseOrgan-on-a-chip is an advanced system for evaluating drug response in diseases. It simulates the in vivo tumor microenvironment, aiding in the understanding of drug mechanisms and tumor responses. It mimics the structure of the tumor microenvironment and the dynamic conditions within the body.
Hyo-Il Jung
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The Microenvironment of Solid Tumors: Components and Current Challenges of Tumor-on-a-Chip Models
Tissue Engineering Part B: ReviewsSolid tumors represent the most common type of cancer in humans and are classified into sarcomas, lymphomas, and carcinomas based on the originating cells. Among these, carcinomas, which arise from epithelial and glandular cells lining the body's tissues, are the most prevalent.
Ilva de Fátima, Souza +4 more
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Tumor organoid and tumor-on-a-chip equipped next generation precision medicine
BiofabricationAbstract Recently, significant advancements have been witnessed in various in vitro treatment evaluation models, especially organoids and organs-on-chips. In vitro culture of cancer cells and drug screening are key technical components in functional oncology precision medicine. However, most studies primarily focus on constructing models
Wentao Zhao +8 more
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Computational model of the cancer necrotic core formation in a tumor-on-a-chip device
Journal of Theoretical BiologyThe mechanisms underlying the formation of necrotic regions within avascular tumors are complex and poorly understood. In this paper, we investigate the formation of a necrotic core in a 3D tumor cell culture within a microfluidic device, considering oxygen, nutrients, and the microenvironment acidification by means of a computational-mathematical ...
Bonifácio, Elton Diêgo +6 more
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Tumor-on-a-chip devices for cancer immunotherapy
2022Xuan Mu, Yu Shrike Zhang
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