Nivolumab plus Ipilimumab in Lung Cancer with a High Tumor Mutational Burden
New England Journal of Medicine, 2018 BACKGROUND Nivolumab plus ipilimumab showed promising efficacy for the treatment of non–small‐cell lung cancer (NSCLC) in a phase 1 trial, and tumor mutational burden has emerged as a potential biomarker of benefit.
M. Hellmann +23 more
semanticscholar +1 more source
Targeting tumor multicellular aggregation through IGPR-1 inhibits colon cancer growth and improves chemotherapy [PDF]
, 2017 Adhesion to extracellular matrix (ECM) is crucially important for survival of normal epithelial cells as detachment from ECM triggers specific apoptosis known as anoikis.
A C Belkina +7 more
core +1 more source
Dual-energy CT perfusion imaging for differentiating WHO subtypes of thymic epithelial tumors
Scientific Reports, 2020 To evaluate the role of conventional contrast-enhanced CT (CECT) imaging and dual-energy spectral CT (DECT) perfusion imaging in differentiating the WHO histological subtypes of thymic epithelial tumours (TETs).
Chunhai Yu +6 more
doaj +1 more source
Satb1 overexpression drives tumor-promoting activities in cancer-associated dendritic cells [PDF]
, 2016 Special AT-rich sequence-binding protein 1 (Satb1) governs genome-wide transcriptional programs. Using a conditional knockout mouse, we find that Satb1 is required for normal differentiation of conventional dendritic cells (DCs).
Allegrezza, Michael J. +14 more
core +1 more source
Circulating tumor cells in genitourinary tumors [PDF]
Therapeutic Advances in Urology, 2017 Management of advanced urogenital malignancies has profoundly changed in recent years due to the development of novel targeted drugs that have significantly improved patient’s clinical outcomes. This process has been made possible mainly thanks to better knowledge of tumor genetic alterations and molecular altered pathways.
Massari, Francesco +8 more
openaire +4 more sources
Research Advances in Antitumor Mechanism of Evodiamine
Journal of Chemistry, 2022 Evodiamine is a natural alkaloid extracted from Fructus Evodia. This bioactive alkaloid has been reported to have a wide range of biological activities, including anti-injury, antiobesity, vasodilator, and anti-inflammatory effects.
Luning Li +5 more
doaj +1 more source
The Tumor Microenvironment Innately Modulates Cancer Progression.
Cancer Research, 2019 Cancer development and progression occurs in concert with alterations in the surrounding stroma. Cancer cells can functionally sculpt their microenvironment through the secretion of various cytokines, chemokines, and other factors.
D. Hinshaw, L. Shevde
semanticscholar +1 more source
Prognostic significance of primary-tumor extension, stage and grade of nuclear differentiation in patients with renal cell carcinoma [PDF]
, 2002 Surgery remains the preferred therapy for renal cell carcinoma. The various adjunctive or complementary therapies currently yield disappointing results. Identifying reliable prognostic factors could help in selecting patients most likely to benefit from ...
Barbarosos A +7 more
core
Tumor neoantigens and tumor immunotherapies
AGING MEDICINEAbstractAs a high‐risk group of patients with cancer, the elderly exhibit limited efficacy with traditional treatments. Immunotherapy emerges as a promising adjunctive therapeutic approach that holds potential in addressing the needs of geriatric patients with cancer.
Wang Jiani, Tan Qin, Ma Jie
openaire +3 more sources
The dual nature of TDC – bridging dendritic and T cells in immunity
FEBS Letters, EarlyView.TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
wiley +1 more source