Results 61 to 70 of about 8,258,963 (388)
Research Advances in Antitumor Mechanism of Evodiamine
Journal of Chemistry, 2022 Evodiamine is a natural alkaloid extracted from Fructus Evodia. This bioactive alkaloid has been reported to have a wide range of biological activities, including anti-injury, antiobesity, vasodilator, and anti-inflammatory effects.
Luning Li +5 more
doaj +1 more source
Nivolumab plus Ipilimumab in Lung Cancer with a High Tumor Mutational Burden
New England Journal of Medicine, 2018 BACKGROUND Nivolumab plus ipilimumab showed promising efficacy for the treatment of non–small‐cell lung cancer (NSCLC) in a phase 1 trial, and tumor mutational burden has emerged as a potential biomarker of benefit.
M. Hellmann +23 more
semanticscholar +1 more source
Syntaphilin controls a mitochondrial rheostat for proliferation-motility decisions in cancer. [PDF]
, 2017 Tumors adapt to an unfavorable microenvironment by controlling the balance between cell proliferation and cell motility, but the regulators of this process are largely unknown.
Ashani T. Weeraratna +17 more
core +2 more sources
The Tumor Microenvironment Innately Modulates Cancer Progression.
Cancer Research, 2019 Cancer development and progression occurs in concert with alterations in the surrounding stroma. Cancer cells can functionally sculpt their microenvironment through the secretion of various cytokines, chemokines, and other factors.
D. Hinshaw, L. Shevde
semanticscholar +1 more source
Gasdermin E suppresses tumor growth by activating anti-tumor immunity
Nature, 2020 Cleavage of the gasdermin proteins to produce pore-forming amino-terminal fragments causes inflammatory cell death (pyroptosis)1. Gasdermin E (GSDME, also known as DFNA5)—mutated in familial ageing-related hearing loss2—can be cleaved by caspase 3 ...
Zhibin Zhang +13 more
semanticscholar +1 more source
The importance of circulating tumor products as „liquid biopsies” in colorectal cancer [PDF]
, 2018 Liquid biopsies represent an array of plasma analysis tests that are studied to evaluate and identify circulating tumor products, especially circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA).
Calborean, Veronica +6 more
core +4 more sources
World Journal of Surgical Oncology, 2022 Background Gastric cancer (GC) is the sixth most common cancer. China is one of the most frequent GC occurred countries, and Wuwei, Gansu, is one of the highest incidence area in China.
Ping Fan +6 more
doaj +1 more source
Tumor neoantigens and tumor immunotherapies
AGING MEDICINEAbstractAs a high‐risk group of patients with cancer, the elderly exhibit limited efficacy with traditional treatments. Immunotherapy emerges as a promising adjunctive therapeutic approach that holds potential in addressing the needs of geriatric patients with cancer.
Wang Jiani, Tan Qin, Ma Jie
openaire +3 more sources
Circulating tumor cells in genitourinary tumors [PDF]
Therapeutic Advances in Urology, 2017 Management of advanced urogenital malignancies has profoundly changed in recent years due to the development of novel targeted drugs that have significantly improved patient’s clinical outcomes. This process has been made possible mainly thanks to better knowledge of tumor genetic alterations and molecular altered pathways.
Massari, Francesco +8 more
openaire +4 more sources
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source