Results 81 to 90 of about 8,258,963 (388)

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

DDR2 controls breast tumor stiffness and metastasis by regulating integrin mediated mechanotransduction in CAFs [PDF]

, 2019
Biomechanical changes in the tumor microenvironment influence tumor progression and metastases. Collagen content and fiber organization within the tumor stroma are major contributors to biomechanical changes (e., tumor stiffness) and correlated with ...
Barcus, Craig E, Bayer, Samantha V.H., Brenot, Audrey, Ernst, Melanie, Grither, Whitney R, Hwang, Priscilla Y, Longmore, Gregory D, Pathak, Amit, Pence, Patrick, Walter, Christopher   +9 more
core   +1 more source

Circulating tumor cells, disease progression, and survival in metastatic breast cancer.

New England Journal of Medicine, 2004
BACKGROUND We tested the hypothesis that the level of circulating tumor cells can predict survival in metastatic breast cancer. METHODS In a prospective, multicenter study, we tested 177 patients with measurable metastatic breast cancer for levels of ...
M. Cristofanilli, G. Budd, M. Ellis, A. Stopeck, J. Matera, M. Miller, J. Reuben, G. Doyle, W. Allard, L. Terstappen, D. Hayes   +10 more
semanticscholar   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Enhancement of experimental metastasis by tumor necrosis factor [PDF]

, 1993
The influence of endogenous and exogenous tumor necrosis factor (TNF) on metastasis was investigated in an experimental fibrosarcoma metastasis model.
Echtenacher, Bernd, Falk, Werner, Männel, Daniela N., Orosz, P., Rüschoff, J., Weber, D.   +5 more
core   +2 more sources

Tumors benignes vs. tumors malignes [PDF]

Llengua, Societat i Comunicaci�, 2012
Tumor is the word used to refer to an abnormal, excessive growth of a mass of certain cells, which can be similar to normal tissue cells or which can be atypical to other bodily cells. The essential difference between benign and malignant tumors lies in the latter’s ability to spread throughout the body, making their prognoses worse than those of ...
openaire   +3 more sources

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

Adjuvant therapeutic potential of tonabersat in the standard treatment of glioblastoma : a preclinical F98 glioblastoma rat model study [PDF]

, 2019
Purpose Even with an optimal treatment protocol, the median survival of glioblastoma (GB) patients is only 12-15 months. Hence, there is need for novel effective therapies that improve survival outcomes.
Bonte, Ellen, De Meulenaere, Valerie, De Wever, Olivier, Deblaere, Karel, Descamps, Benedicte, Goethals, Ingeborg, Kalala Okito, Jean-Pierre, Leybaert, Luc, Pieters, Leen, Vanhove, Christian, Verhoeven, Jeroen, Vral, Anne   +11 more
core   +1 more source

Adenomatoid odontogenic tumor, an uncommon tumor

Contemporary Clinical Dentistry, 2012
Here we report a case of adenomatoid odontogenic tumor (AOT) in the maxilla in a young girl aged 14 years and its surgical management. We also review the literature and variations in the nomenclature and classifications of this interesting tumor. The review of literature gives an interesting picture regarding terminologies in the past and dilemma in ...
Senthil Kumar, Srivel Vigneswari, Vijayasamundeeswari, Karthick Vasudevan   +3 more
openaire   +4 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source