Results 91 to 100 of about 68,638 (278)

Galectin-1 sensitizes resting human T lymphocytes to Fas (CD95)-mediated cell death via mitochondrial hyperpolarization, budding, and fission. [PDF]

, 2005
Galectins have emerged as a novel family of immunoregulatory proteins implicated in T cell homeostasis. Recent studies showed that galectin-1 (Gal-1) plays a key role in tumor-immune escape by killing antitumor effector T cells.
Ascione, Barbara, Bianco, German Ariel, Malorni, Walter, Matarrese, Paola, Mormone, Elisabetta, Rabinovich, Gabriel Adrián, Tinari, Antonella, Toscano, Marta Alicia   +7 more
core   +1 more source

Single‐Cell Mitochondrial Lineage Tracing Decodes Fate Decision and Spatial Clonal Architecture in Human Hematopoietic Organoids

Advanced Science, EarlyView.
This study repurposes mitochondrial DNA mutations as endogenous barcodes for lineage tracing in human pluripotent stem cell‐derived organoids. Integrated with transcriptomic and spatial data, it reveals NOTCH‐mediated stromal‐progenitor crosstalk orchestrates clonal dynamics and spatial zonation during early hematopoietic development, offering a non ...
Yan Xue, Junhao Su, Yiming Chao, Lu Liu, Xinyi Lin, Yang Xiang, Mun Kay Ho, Zezhuo Su, Junyi Chen, Zhuojuan Luo, Chengqi Lin, Ruibang Luo, Theo Aurich, Jianfeng Wu, Kelvin Sin Chi Cheung, Yuanhua Huang, Joshua W. K. Ho, Ryohichi Sugimura   +17 more
wiley   +1 more source

Disrupting Lipid Raft Microdomains to Block Polyploid Giant Cancer Cell Budding and Enhance Radiotherapy Response

Advanced Science, EarlyView.
Radiation induces polyploid giant cancer cells (PGCCs) that regenerate tumors through virus‐like budding. This process depends on a SNCG–FLOT2–CHMP4B signaling axis functioning in lipid raft microdomains. Disrupting these domains using statins or anti‐PCSK9 antibodies blocks PGCC budding, suppresses tumor repopulation, and enhances radiotherapy ...
Zheng Deng, Haoran Sun, Jin Cheng, Ruyi Zhao, Jianzhu Xie, Yanwei Song, Yucui Zhao, Chenwei Lin, Binjie Hu, Yanping Gong, Jun Lin, Sijia He, Yuntao Luo, Minghui Zhao, Yiwei Wang, Ming Jiao, Yuqin Yang, Jikun Li, Shujie Xia, Chuanyuan Li, Qian Huang   +20 more
wiley   +1 more source

Evaluation of the Potential Prognostic Value of Tumor Budding in Laryngeal Carcinoma by Conventional and Immunohistochemical Staining

Analytical Cellular Pathology, 2020
Background. Tumor budding is a promising prognostic indicator in several cancers especially in colorectal cancer. However, only few studies have been conducted to assess and validate its prognostic value in laryngeal squamous cell carcinoma; none of ...
Nermine M. Abd Raboh, Ossama M. Mady, Sarah A. Hakim   +2 more
doaj   +1 more source

Rad54: the Swiss Army knife of homologous recombination? [PDF]

, 2006
Homologous recombination (HR) is a ubiquitous cellular pathway that mediates transfer of genetic information between homologous or near homologous (homeologous) DNA sequences. During meiosis it ensures proper chromosome segregation in the first division.
Heyer, Wolf-Dietrich, Li, Xuan, Rolfsmeier, Michael, Zhang, Xiao-Ping   +3 more
core   +2 more sources

Impact of Two‐Team Surgery on Short‐ and Long‐Term Outcomes of Transanal Total Mesorectal Excision for Rectal Cancer

Annals of Gastroenterological Surgery, EarlyView.
This study investigated the impact of two‐team surgery on short‐ and long‐term outcomes of transanal total mesorectal excision for rectal cancer. Two‐team surgery has some advantages over one‐team surgery, such as shorter operation time, decreased estimated blood loss, increased number of lymph nodes dissected, and decreased positive distal margin ...
Nobuaki Hoshino, Koya Hida, Yukinari Tokoro, Kazutaka Obama, Takeru Matsuda, Ichiro Takemasa, Tomonori Akagi, Masafumi Inomata, Shigenori Homma, Nobuki Ichikawa, Yoshihiro Kakeji, Seiichiro Yamamoto, Takeshi Naitoh, Ta‐Ta‐Mi study group collaboratives in Japan Society of Laparoscopic Colorectal Surgery   +13 more
wiley   +1 more source

Establish a novel tumor budding-related signature to predict prognosis and guide clinical therapy in colorectal cancer

Scientific Reports
Tumor budding is a long-established independent adverse prognostic marker for colorectal cancer (CRC), yet assessment of tumor budding was not reproducible. Therefore, development of precise diagnostic approaches to tumor budding is in demand.
Qixin Li, Gaixia Liu, Quanpeng Qiu, Jiaqi Zhang, Ruizhe Li, Jiamian Zhao, Junjun She, Yinnan Chen   +7 more
doaj   +1 more source

RAD54 family translocases counter genotoxic effects of RAD51 in human tumor cells. [PDF]

, 2015
The RAD54 family DNA translocases have several biochemical activities. One activity, demonstrated previously for the budding yeast translocases, is ATPase-dependent disruption of RAD51-dsDNA binding.
Bishop, Douglas K, Budke, Brian, Connell, Philip P, Dusad, Kritika, Grubb, Jennifer, Heyer, Wolf-Dietrich, Mason, Jennifer M, Weichselbaum, Ralph R, Wright, William Douglass   +8 more
core   +2 more sources

Assessment of cyclin D1 activity in tumors and tumor budding and its prognostic significance in tumor budding in colorectal carcinomas

Indian Journal of Pathology and Microbiology
ABSTRACT Background: The most important prognostic parameter is staging in colorectal cancers, and tumor budding (TB) is among the independent prognostic parameters that are increasing in significance. Cyclin D1 expression has been associated with poor prognosis as a marker of various tumors.
Ganime Coban, Dilek S. Arici, Busra C. Tekden, Pelin Yildiz, Tugce Kiran, Özlem Toluk, Haci M. Turk, Nurhan Şahin   +7 more
openaire   +3 more sources

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source