Results 71 to 80 of about 1,252,032 (285)

Prognostic Significance of Tumor Budding in Urothelial Carcinomas of the Bladder: Comparison of Two Different Tumor Budding Evaluation Methods

Medical Records, 2022
Aim: In our study, we aimed to reveal the effect of tumor budding(TB) on prognosis in urothelial carcinomas and to compare the most commonly used alternative method (AM) and the International Tumor Budding Consensus Conference (ITBCC) system. TB can be easily assessed on routine hematoxylin and eosin-stained slides.
İrfan ÖCAL, İsmail GÜZELİŞ
openaire   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

A study of tumor budding and the factors, affecting interpretability of peritumoral budding, based on endoscopic colorectal biopsies from the left and right sided colorectal carcinoma [PDF]

Journal of Biomedical & Clinical Research
In this paper we summarize the results of a retrospective investigation of tumor budding in endoscopic preoperative biopsies in patients with colorectal adenocarcinoma (CRC).
Krasimir T. Petrov, Ivan Ivanov, Tatyana Betova, Reni Tsvetkova, Radoslav Trifonov, Savelina Popovska   +5 more
doaj   +3 more sources

Phenotyping of tumor-associated macrophages in colorectal cancer: Impact on single cell invasion (tumor budding) and clinicopathological outcome. [PDF]

, 2016
Tumor-associated macrophages (TAM) play a controversial role in epithelial-mesenchymal transition (EMT) and prognosis of colorectal cancer (CRC). In particular, the microlocalization, polarization and prognostic impact of TAM in the immediate environment
Canonica, Katharina, Kölzer, Viktor, Sokol, Lena, Lugli, Alessandro, Zlobec, Inti, Koelzer, Viktor H, Dawson, Heather, Karamitopoulou, Evanthia, Karamitopoulou-Diamantis, Eva   +8 more
core   +1 more source

Matrix Stiffness Enhances Odontogenic Differentiation of DPSCs through Membrane Curvature Protein Baiap2‐Modulated Exosome Release

Advanced Science, EarlyView.
Matrix stiffness softening is identified as a previously underappreciated feature in deep caries. Higher stiffness drives exosome release in dental pulp stem cells through a coordinated mechanism involving PI3K–AKT‐regulated Baiap2 and kinesin‐1, thereby promoting odontogenic differentiation.
Bilun Jin, Shaojie Dong, Yue Jia, Zhao Xu, Peiqi Liu, Zhaojing Ding, Yuxin Liao, Rui Zou, Jinsong Hu, Bo Cheng, Lin Niu   +10 more
wiley   +1 more source

Assessment of cyclin D1 activity in tumors and tumor budding and its prognostic significance in tumor budding in colorectal carcinomas

Indian Journal of Pathology and Microbiology
ABSTRACT Background: The most important prognostic parameter is staging in colorectal cancers, and tumor budding (TB) is among the independent prognostic parameters that are increasing in significance. Cyclin D1 expression has been associated with poor prognosis as a marker of various tumors.
Ganime Coban, Dilek S. Arici, Busra C. Tekden, Pelin Yildiz, Tugce Kiran, Özlem Toluk, Haci M. Turk, Nurhan Şahin   +7 more
openaire   +3 more sources

Prognostic Value of Tumor Budding for Early Breast Cancer

Biomedicines, 2023
Background: Tumor budding (TB) is a dynamic process associated with the epithelial–mesenchymal transition and a well-established prognostic biomarker for colorectal cancer. As part of the tumor microenvironment, tumor buds demonstrate increased cell motility and invasiveness.
Silva, Diogo J., Miranda, Gonçalo, Amaro, Teresina, Salgado, Matilde, Mesquita, Alexandra   +4 more
openaire   +3 more sources

TED1 Promotes the Assembly of SCFD3‐D14‐D53 to Reinforce Strigolactone Signaling in Rice

Advanced Science, EarlyView.
This study identifies TED1 as a positive regulator of strigolactones (SL) signaling in rice. The ted1 mutants display dwarfism and increased tillering with significantly reduced SLs sensitivity. Through its longer C‐terminal region, TED1 interacts with D53 and D14 to promote the assembly of SCFD3‐D14‐D53, thereby facilitating the efficient ...
Sheng Luo, Chuanyin Wu, Miao Feng, Wenfan Luo, Rong Miao, Jinsheng Qian, Fan Wang, Chunlei Zhou, Bojuan Liu, Jiale Shao, Ziqi Xun, Yehui Xiong, Zhichao Zhao, Cailin Lei, Shanshan Zhu, Yulong Ren, Xin Wang, Xiuping Guo, Haiyang Wang, Zichao Li, Zhijun Cheng, Qibing Lin, Jianmin Wan   +22 more
wiley   +1 more source

Tumor budding outperforms ypT and ypN classification in predicting outcome of rectal cancer after neoadjuvant chemoradiotherapy

BMC Cancer, 2019
Background Budding is a complementary prognostic factor for colorectal cancer. In this study, we aimed to clarify the role of tumor budding in rectal cancer patients after preoperative chemoradiotherapy. Methods A total of 124 patients with rectal cancer
Iryna Trotsyuk, Halina Sparschuh, Alice Josephine Müller, Konrad Neumann, Martin Kruschewski, David Horst, Sefer Elezkurtaj   +6 more
doaj   +1 more source

TWIST1 and TWIST2 promoter methylation and protein expression in tumor stroma influence the epithelial-mesenchymal transition-like tumor budding phenotype in colorectal cancer. [PDF]

, 2015
Tumor budding in colorectal cancer is likened to an epithelial-mesenchymal transition (EMT) characterized predominantly by loss of E-cadherin and up-regulation of E-cadherin repressors like TWIST1 and TWIST2.
Galván Hernández, José Alberto, Kölzer, Viktor, Karamitopoulou, Eva, Zlobec, Inti, Tschan, Mario, Dawson, Heather; https://orcid.org/, Inderbitzin, Daniel, Helbling, Melina, Karamitopoulou, Evanthia, Koelzer, Viktor H; https://orcid.org/, Berger, Martin D, Galván, José A, Lugli, Alessandro, Zlobec, Inti; https://orcid.org/, Dawson, Heather, Hädrich, Marion, Tschan, Mario P, Berger, Martin Dave, Schnüriger, Beat   +18 more
core   +2 more sources