Results 181 to 190 of about 2,710,879 (342)

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Tumor-associated macrophages educated by IGSF9 exhibit a senescence-associated secretory phenotype to promote tumor immune escape. [PDF]

J Immunother Cancer
Zhang J, Meng X, Zhao X, Luan H, Li F, Wang T, Sun Y, Liu G, Pang Y, Xu A, Wang H, Li C, Hui L, Li F, Wei S, Yu H, Wang Y, Li Z.   +17 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Hypoxia induced VEGF secretion promotes resistance to bispecific T-cell engagers. [PDF]

Signal Transduct Target Ther
Xu M, Barakzai SK, Kumar R, Veillard I, Kim E, Bregar A, Eisenhauer E, Penson R, Bouberhan S, Filipi J, Colella T, Bond T, Clark C, Lin LH, Ruan J, Wang C, Qin X, Sarosiek K, Rueda B, Castro C, Spriggs DR, Yeku OO.   +21 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Adipose Stromal Cell-Derived Cancer-Associated Fibroblasts Promote Pancreatic Adenocarcinoma Progression Through SFRP4 Signaling. [PDF]

Cancers (Basel)
Rupert J, Cai L, Daquinag AC, Anastassiou D, Kolonin MG.   +4 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

CD9-positive tumor-associated macrophages promote renal cell carcinoma progression by activating the orphan nuclear receptor Nor1/Nr4a3. [PDF]

Cancer Cell Int
Pan P, Li S, Yin W, Wang P, Ma T, Bi Z, Song J, Song X, Huang X, Hao J, Chen G, Zhao Q.   +11 more
europepmc   +1 more source

Requisite endothelial reactivation and effective siRNA nanoparticle targeting of Etv2/Er71 in tumor angiogenesis [PDF]

, 2018
Berry, Jeffrey C, Choi, Kyunghee, Hamilton, Samantha, Hinman, Kristina, Kabir, Ashraf Ul, Kang, Hee-Kyoung, Krchma, Karen, Lee, Tae-Jin, Liu, Fang, Mecham, Robert P, Miller, Mark J, Pan, Hua, Veis, Deborah J, Wickline, Samuel A, Wu, Jun, Yang, Lihua, Zhou, Qingyu   +16 more
core   +2 more sources

Motility of Cultured Brain Tumor Cells

Neurologia medico-chirurgica, 1981
openaire   +2 more sources