Results 61 to 70 of about 5,932,486 (309)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Silencing of TGF-β1 in tumor cells impacts MMP-9 in tumor microenvironment

Scientific Reports, 2017
Transforming growth factor (TGF)-β1 contributes to autocrine and paracrine functions in the tumor microenvironment (TME). The present study examined the effects of TGF-β1 crosstalk in TME and its role in mediating tumor formation and progression by ...
Lakisha D. Moore-Smith, Tatyana Isayeva, Joo Hyoung Lee, Andra Frost, Selvarangan Ponnazhagan   +4 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Effect of immunization with fetal cells on adenovirus-12 oncogenesis [PDF]

, 1974
The effect of immunization with hamster fetal cells on the tumor induction by adnovirus type 12 was studied by in vivo and in vitro. The immunization with lO-day old fetal cells showed a recognizable inhibition on the tumor induction by adenovirus type ...
Abe, Shinji
core   +1 more source

Tumor ⁃ associated macrophages secrete TGFBI to promote malignancy of glioma stem cells in vitro

Chinese Journal of Contemporary Neurology and Neurosurgery, 2019
Objective To investigate the expression heterogeneity of transforming growth factor⁃β⁃induced protein (TGFBI) in glioblastoma (GBM) multiform and the mechanism of its promotion on malignancy of glioma stem cells (GSCs) in vitro.
Hong⁃tao ZHU, Dan LIU, Zi⁃rong CHEN, Ya⁃kun LI, Zhen WANG, Fang⁃ling CHENG, Jia⁃min LIU, Suo⁃jun ZHANG, Bin ZHANG, Feng WAN   +9 more
doaj  

The tumor-educated-macrophage increase of malignancy of human pancreatic cancer is prevented by zoledronic acid. [PDF]

PLoS ONE, 2014
We previously defined macrophages harvested from the peritoneal cavity of nude mice with subcutaneous human pancreatic tumors as "tumor-educated-macrophages" (Edu) and macrophages harvested from mice without tumors as "naïve-macrophages" (Naïve), and ...
Yukihiko Hiroshima, Ali Maawy, Mohamed K Hassanein, Rhiana Menen, Masashi Momiyama, Takashi Murakami, Shinji Miwa, Mako Yamamoto, Fuminari Uehara, Shuya Yano, Ryutaro Mori, Ryusei Matsuyama, Takashi Chishima, Kuniya Tanaka, Yasushi Ichikawa, Michael Bouvet, Itaru Endo, Robert M Hoffman   +17 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Effects of oncolytic immunotherapy with RP1 (vusolimogene oderparepvec) on immune cells mediate responsiveness to anti-PD-1 via STING-mediated interferon signaling

Journal for ImmunoTherapy of Cancer
Background Antitumor immune responses induced by oncolytic immunotherapy (OI) are often followed by upregulation of programmed death-ligand 1 (PD-L1). As such, the combination of OI with blockade of the programmed cell death protein-1 (PD-1)/PD-L1 axis ...
Alan Melcher, David Mansfield, Linta Kuncheria, Victoria Roulstone, Kevin J Harrington, Isla Leslie, Shane Foo, Robert S Coffin, Martin McLaughlin, Malin Pedersen, Elizabeth Appleton, Richard Vile, Holly Baldock, Joan Kyula, Praveen K Bommareddy, Charleen ML Chan Wah Hak, Anton Patrikeev, Nitya Mohan, Jim Gkantalis, Henry G Smith, Emmanuel Christian Patin, Sylwia Jones, Amarin Wongariyapak, Robert Pickering, Christian Zierhut, Carmen Murano, Lisa C Hubbard, Isaac Dean, Maria Goicoechea, Scott Layzell, Jonathan Mannion, Winnie Fernando   +31 more
doaj   +1 more source

CXCL9 secreted by tumor-associated dendritic cells up-regulates PD-L1 expression in bladder cancer cells by activating the CXCR3 signaling

BMC Immunology, 2021
Background Tumor-associated dendritic cells (TADCs) can interact with tumor cells to suppress anti-tumor T cell immunity. However, there is no information on whether and how TADCs can modulate programmed death-ligand 1 (PD-L1) expression by cancer cells.
Weigang Xiu, Jingjing Luo
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source