Results 51 to 60 of about 913,938 (308)

Autophagy-deficient breast cancer shows early tumor recurrence and escape from dormancy [PDF]

, 2018
Breast cancer patients who initially respond to cancer therapies often succumb to distant recurrence of the disease. It is not clear why people with the same type of breast cancer respond to treatments differently; some escape from dormancy and relapse ...
Manjili, Masoud H.
core   +1 more source

Isolation of Tumor Cell Colonies in Tissue Culture.

Experimental Biology and Medicine, 1958
SummaryA procedure is described for isolation of colonies of mammalian cells in tissue culture. Cell lines of a mouse ependymoma obtained in this way differed in growth characteristics, in capacity to grow, in vivo, and in susceptibility to Theiler's GDVII virus.
H E, PEARSON, D L, LAGERBORG
openaire   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Influence of polyamine analogue DENSPM on cell growth of human SNB19 glioblastoma cells

Chinese Journal of Contemporary Neurology and Neurosurgery, 2011
Objective To investigate the influence of polyamine analogue DENSPM (N1, N11-diethylnorspermine) on cell growth of human SNB19 glioblastoma cells. Methods DENSPM was added into the culture medium of SNB19 cells. MTS assay was used to assess cell survival
Ye TIAN, Bin WANG, Shizhao WANG, Zhengjun WEI, Lin SUN, Rongcai JIANG, Jianning ZHANG   +6 more
doaj  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Tumor ⁃ associated macrophages secrete TGFBI to promote malignancy of glioma stem cells in vitro

Chinese Journal of Contemporary Neurology and Neurosurgery, 2019
Objective To investigate the expression heterogeneity of transforming growth factor⁃β⁃induced protein (TGFBI) in glioblastoma (GBM) multiform and the mechanism of its promotion on malignancy of glioma stem cells (GSCs) in vitro.
Hong⁃tao ZHU, Dan LIU, Zi⁃rong CHEN, Ya⁃kun LI, Zhen WANG, Fang⁃ling CHENG, Jia⁃min LIU, Suo⁃jun ZHANG, Bin ZHANG, Feng WAN   +9 more
doaj  

Blue light irradiation inhibits the M2 polarization of the cancer-associated macrophages in colon cancer

BMC Cancer
Recent studies have shown that blue light-emitting diode (LED) light has anti-tumor effects, suggesting the possibility of using visible light in cancer therapy.
Toshiaki Yoshimoto, Masaaki Nishi, Shohei Okikawa, Kozo Yoshikawa, Takuya Tokunaga, Toshihiro Nakao, Chie Takasu, Hideya Kashihara, Yuma Wada, Takayuki Noma, Mitsuo Shimada   +10 more
doaj   +1 more source

Silencing of TGF-β1 in tumor cells impacts MMP-9 in tumor microenvironment

Scientific Reports, 2017
Transforming growth factor (TGF)-β1 contributes to autocrine and paracrine functions in the tumor microenvironment (TME). The present study examined the effects of TGF-β1 crosstalk in TME and its role in mediating tumor formation and progression by ...
Lakisha D. Moore-Smith, Tatyana Isayeva, Joo Hyoung Lee, Andra Frost, Selvarangan Ponnazhagan   +4 more
doaj   +1 more source

Inhibiting effect of immunoeffector cells induced by denderitic cells vaccine on growth of PC3 and BEL7402

Journal of Acute Disease, 2018
Objective: To compare effect of immunoprevention or immunotherapy based on denderitic cells (DCs), or supernatants on pancreatic carcinoma and hepatocelluar carcinoma in vitro and in vivo.
Zao-Xi Sun, Zheng-Ke Sun, Kai Li, Ping Long, Ya-Chen Xu, Qiu-Xi Yang, Hai-Rong Huan, Cheng-Yi Sun   +7 more
doaj   +1 more source

Expression of PD-L1 on Monocytes Is a Novel Predictor of Prognosis in Natural Killer/T-Cell Lymphoma

Frontiers in Oncology, 2020
Background: Natural killer/T-cell lymphoma (NKTCL) is a highly aggressive lymphoma with a dismal prognosis, and novel therapeutic targets are urgently needed. Programmed death-ligand 1 (PD-L1) has become a promising therapeutic target for various cancers,
Xue-wen Zhang, Xue-wen Zhang, Xi-wen Bi, Xi-wen Bi, Pan-pan Liu, Pan-pan Liu, Ze-long Liu, Ze-long Liu, Man Nie, Man Nie, Hang Yang, Hang Yang, De-xin Lei, De-xin Lei, Yi Xia, Yi Xia, Wen-qi Jiang, Wen-qi Jiang, Wei-an Zeng, Wei-an Zeng   +19 more
doaj   +1 more source