Results 31 to 40 of about 651,598 (267)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Establishment and evaluation of melanoma model

Journal of Hebei University of Science and Technology, 2018
In order to screen drug rapidly and effectively in vivo, the approach of the establishment for mouse melanoma model with primary cell from melanin solid tumor tissue of mouse is studied.
Xiangli YAO, Xuguang MIAO, Xixi WEI, Xuan WANG, Shouxin LIU   +4 more
doaj   +1 more source

Human esophageal fibroblast-derived exosomal miR-21 reduced the cisplatin sensitivity to esophageal carcinoma EC9706 cells

Brazilian Journal of Medical and Biological Research, 2021
The objective of this study was to investigate the effect of human esophageal fibroblast-derived exosomal miR-21 on cisplatin sensitivity against esophageal squamous EC9706 cells. EC9706 cells were co-cultured indirectly with human esophageal fibroblasts
Jiajin Wan, Chunling Niu, Baiyan Wang, Qianqian Han, Yulon Chen, Shuying Feng, Lianhe Yang   +6 more
doaj   +1 more source

 Three‑dimensional culture of tumor cells (Review)

Oncology Letters
While conventional two-dimensional (2D) cell cultures and animal models have been cornerstone technologies in cancer research, they possess limitations in replicating human tumor pathophysiology. Notably, 2D models fail to capture key tissue-level architecture and cell-cell interactions, whereas animal models are often constrained by species-specific ...
Du, Shiyao, Yang, Jinyu, Li, Hui, Men, Shanshan, Xu, Dongping, Wang, Haifeng   +5 more
openaire   +3 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Influence of polyamine analogue DENSPM on cell growth of human SNB19 glioblastoma cells

Chinese Journal of Contemporary Neurology and Neurosurgery, 2011
Objective To investigate the influence of polyamine analogue DENSPM (N1, N11-diethylnorspermine) on cell growth of human SNB19 glioblastoma cells. Methods DENSPM was added into the culture medium of SNB19 cells. MTS assay was used to assess cell survival
Ye TIAN, Bin WANG, Shizhao WANG, Zhengjun WEI, Lin SUN, Rongcai JIANG, Jianning ZHANG   +6 more
doaj  

Inhibiting effect of immunoeffector cells induced by denderitic cells vaccine on growth of PC3 and BEL7402

Journal of Acute Disease, 2018
Objective: To compare effect of immunoprevention or immunotherapy based on denderitic cells (DCs), or supernatants on pancreatic carcinoma and hepatocelluar carcinoma in vitro and in vivo.
Zao-Xi Sun, Zheng-Ke Sun, Kai Li, Ping Long, Ya-Chen Xu, Qiu-Xi Yang, Hai-Rong Huan, Cheng-Yi Sun   +7 more
doaj   +1 more source

Intraperitoneal Mesenchymal Cells Promote the Development of Peritoneal Metastasis Partly by Supporting Long Migration of Disseminated Tumor Cells. [PDF]

PLoS ONE, 2016
The human peritoneal cavity contains a small number of free cells of mesenchymal cell lineage. Intraperitoneal mesenchymal cells (PMC) play supportive roles in metastasis formation on the peritoneum.
Joji Kitayama, Hironori Yamaguchi, Hironori Ishigami, Keisuke Matsuzaki, Naohiro Sata   +4 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source