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This chapter summarizes clinical evidence on tumor dormancy, with a special focus on our research supporting the role of dormancy both in local and distant recurrence of breast cancer following mastectomy. Starting from these premises, we propose a model of neoplastic development that allows us to elucidate several relevant clinical phenomena ...
Romano, Demicheli, Elia, Biganzoli
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Romano, Demicheli, Elia, Biganzoli
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Molecular mechanisms underlying tumor dormancy
Cancer Letters, 2010Evidence suggests that dormant, microscopic tumors are not only common, but are highly prevalent in otherwise healthy individuals. Due to their small size and non-invasive nature, these dormant tumors remain asymptomatic and, in most cases, undetected.
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Circulating Tumor Cells and Tumor Dormancy
2016Metastatic cancer can recur months or even years after apparently successful treatment of the primary tumor. While the exact mechanisms leading to cancer recurrence remain poorly understood, failure to completely eliminate dormant micrometastases and solitary metastatic cells is believed to be a major contributor.
Alison L. Allan, Ann F. Chambers
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Cell dormancy and tumor refractory.
Anti-cancer agents in medicinal chemistry, 2013Metastasis of tumor cells from primary tumor and growth at secondary sites are the major cause of mortality in cancer patients. This event may occur years and even decades after successful removal of the primary tumor and adjuvant therapy. Relapse and metastasis are universally existed in various malignancies.
Kaixiu, Wang +4 more
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The epigenetic/noncoding origin of tumor dormancy
Trends in Molecular Medicine, 2015Cancer stem cells (CSCs) have been implicated as the seeds of treatment resistance and metastasis, which are the most deadly features of a neoplasm. However, an unequivocal definition of the CSC phenotype is still missing. A common feature of normal and aberrant stem cells is their ability to enter a prolonged dormant state.
Francesco, Crea +3 more
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Duodecim; laaketieteellinen aikakauskirja, 2014
Whereas tumor dormancy occurs in melanomas, renal carcinomas and non-Hodgkin lymphomas, late recurrence is characteristic of breast cancer in particular. In the early stage, cancer cells break away from the primary tumor into the circulation, some of which are able to attach themselves to a new target tissue and avoid apoptosis.
Leena, Strien +2 more
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Whereas tumor dormancy occurs in melanomas, renal carcinomas and non-Hodgkin lymphomas, late recurrence is characteristic of breast cancer in particular. In the early stage, cancer cells break away from the primary tumor into the circulation, some of which are able to attach themselves to a new target tissue and avoid apoptosis.
Leena, Strien +2 more
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Is Tumor Dormancy Clinically Relevant?
2013Late progressions can be observed with all solid cancers. With the term dormancy a potential cause is offered for these observations. In this article we present a point of view from a cancer registry and analyze clinical data about metastasis (MET)-free survival, post-MET survival, and overall survival to quantify late progressions.
Dieter Hölzel +3 more
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Escape from Tumor Cell Dormancy
2011Abstract : An insiduously terrifying aspect of breast cancer is its propensity to recur in metastatic sites even over a decade after all evidence of cancer has passed. It is obvious that these cells had escaped very early from the primary tumor as this occurs even in small, node-negative and in situ primary lesions, and that these micrometastases ...
Alan Wells, Linda Griffith
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Cancer Stem Cells and Tumor Dormancy
2012The cancer stem cell hypothesis postulates that only a subpopulation of cancer cells in a tumor is capable of initiating, sustaining, and reinitiating tumors, while the bulk of the population comprises non-stem cancer cells that lack tumor initiation potential.
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Sweet dreams: glycosylation controls tumor cell dormancy
Trends in CancerIn a recent study in Cancer Cell, Sreekumar et al. used therapy-associated breast cancer mouse models as well as in vitro dormancy models to identify extracellular matrix (ECM)-related tumor cell-autonomous mechanisms of dormancy in residual tumor cells (RTCs).
Erin Bresnahan +1 more
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