Results 141 to 150 of about 1,922,670 (308)
Advanced Science, EarlyView.As engineered nanomaterials gain prominence in cancer imaging and therapy, understanding their impact on tumor progression becomes increasingly critical. We demonstrate that gold and silica‐coated gold nanomaterials can either suppress or enhance breast cancer metastasis through distinct tumor microenvironment interactions, while identifying ...
Kiana Buttiens +11 more
wiley +1 more source
Hypoxia regulated pathways in urological malignancies
, 2009 Introduction: Kidney Cancer accounts for approximately 2% of all new cancer diagnoses inthe UK each year. Patient survival has improved over the past few decades; however themechanisms of this are yet to be fully elucidated.
Charlesworth, Philip J.S. +1 more
core +1 more source
Advanced Science, EarlyView.Chemotherapy leverages tumor‐cell autophagy to reshape the colorectal cancer immune microenvironment. Autophagy degrades FBXW2 to promote C/EBPβ‐mediated TIMP‐2 transcription and MMP‐9 suppression, driving intra‐tumoral CD8+ T‐cell infiltration. Targeting MMP‐2/9 or restoring TIMP‐2 overcomes chemo‐resistance in autophagy‐deficient tumors. ABSTRACT The
Bing Cheng +12 more
wiley +1 more source
BMC Veterinary ResearchBackground Hypoxia is a detrimental factor in solid tumors, leading to aggressiveness and therapy resistance. OMX, a tunable oxygen carrier from the heme nitric oxide/oxygen-binding (H-NOX) protein family, has the potential to reduce tumor hypoxia.
Sangkyung Choen +4 more
doaj +1 more source
Advanced Science, EarlyView.(i) Aging impairs peripheral nerve regeneration via its dual ferroptosis‐mediated pathologies in senescent schwann cells. (ii) The composite nerve conduit is a symbiosis niche integrating microenvironment‐responsive nanoparticles (Ga‐PTAs) and maxillofacial‐derived mesenchymal stem cells (Mmscs).
Ning Zhan +12 more
wiley +1 more source
Journal of NanobiotechnologyBackground Hypoxia-activated prodrugs present new opportunities for safe and effective tumor drug resistance therapy due to their high selectivity for hypoxic cells.
Peng Chang +9 more
doaj +1 more source
G9a in hypoxia: Linking tumor hypoxia and epigenetic regulation [PDF]
Cell Cycle, 2017 Francesco Casciello, Jason S. Lee
openaire +3 more sources
Libri Oncologici : Croatian Journal of Oncology, 2003 Anemija je glavni uzrok hipoksije u tumorskih bolesnika.Hemoglobin (Hb) u koncentraciji od 150 g/L, zasićen 100%, prenosi oko 200 mL O2/L krvi, dok Hb 75 g/L prenosi oko 100 mL O2/L. U normalnim uvjetima O2 ekstrakcija u tkiva (O2ER) je 0.25, što znači da Hb 150 g/L ostavlja tkivu 50 mL O2/L, a Hb 75 g/L ostavlja 25 mL O2/L - hipoksija. U zdravih osoba
Banović, Miroslav +3 more
openaire +1 more source
Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma
Advanced Science, EarlyView.This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert +8 more
wiley +1 more source
Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer.
, 2020 Tumor hypoxia is associated with poor patient outcomes in estrogen receptor-α-positive (ERα+) breast cancer. Hypoxia is known to affect tumor growth by reprogramming metabolism and regulating amino acid (AA) uptake.
Esther Bridges (8267841) +18 more
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