Results 201 to 210 of about 1,922,670 (308)

Tumor Hypoxia: How Conventional Histology Is Reshaped in Breast Carcinoma. [PDF]

Int J Mol Sci
Juhász P, Méhes G.
europepmc   +1 more source

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

Mechanically Regulated Secretion: How Physical Forces Instruct the Secretory Pathway and Remodel the Secretome

Advanced Science, EarlyView.
Mechanical cues, including ECM stiffness, stretch, compression, shear stress, and traction forces, remodel trafficking across the secretory pathway, from the ER and Golgi to endolysosomal compartments and the plasma membrane. The resulting secretome reshapes ECM composition and tissue mechanics, establishing feedback loops that support homeostasis or ...
Domenico Russo, Seetharaman Parashuraman, Maria Luigia Maresca, Angela Francesca Dinoi, Alessia Calcagnì, Riccardo Rizzo   +5 more
wiley   +1 more source

Oxygen-carrying nanoemulsions and respiratory hyperoxia eliminate tumor hypoxia-induced immunosuppression. [PDF]

JCI Insight
Halpin-Veszeleiova K, Mallouh MP, Williamson LM, Apro AC, Botticello-Romero NR, Bahr C, Shin M, Ward KM, Rosenberg L, Ritov VB, Sitkovsky MV, Jackson EK, Spiess BD, Hatfield SM.   +13 more
europepmc   +1 more source

Intermittent Fasting Reduces Taurine Availability and Promotes Antitumor Immunity Through PERK Attenuation‐Associated Paraptosis‐Like Cell Death in Colorectal Cancer

Advanced Science, EarlyView.
This study identifies reduced taurine availability as a mediator of intermittent fasting in colorectal cancer and shows that taurine interacts with GRP78 to maintain PERK abundance post‐transcriptionally. It further shows that taurine depletion destabilizes PERK, induces immunogenic paraptosis, remodels the tumor microenvironment toward a CD8+ T cell ...
Baohui Song, Sikei Kam, Jingyi Liu, Rui Lv, Xucheng Huo, Zhanghan Chen, Yuelun Dong, Shilun Cai, Bing Li, Ruobing Ren, Yunshi Zhong, Mingyan Cai   +11 more
wiley   +1 more source

Tumor Hypoxia: Long Ignored but Now Detectable and Potentially Actionable. [PDF]

Clin Cancer Res
Mason RP.
europepmc   +1 more source

Self‐Adaptive Biomimetic Nanocomposite Hydrogel Orchestrates Dual‐Targeting and On‐Demand H2S Gasotransmission for Multifactorial Diabetic Wound Therapy

Advanced Science, EarlyView.
A self‐adaptive and biomimetic nanocomposite hydrogel is engineered to orchestrate dual‐targeting and on‐demand H2S gasotransmission for multifactorial diabetic wound therapy. By seamlessly integrating antibacterial, antioxidant, anti‐inflammatory, immunoregulatory, and pro‐angiogenic functions within a single platform, this hydrogel dynamically ...
Kefan Wu, Xiaoxue Yang, Yonghang Liu, Yi Xiao, Shiyu Meng, Ao Li, Yi Zhun Zhu, Hui Guo, Xiaolin Wang   +8 more
wiley   +1 more source

Automatically quantifying spatial heterogeneity of immune and tumor hypoxia environment and predicting disease-free survival for patients with rectal cancer. [PDF]

Cancer Immunol Immunother
Chen S, Liu Z, Wang J, Zhang Z, Dekker A, Wee L, Kalendralis P, Sun Y, Tong T.   +8 more
europepmc   +1 more source

Lactate Signal: Modulator of Cellular Energy Production and Anabolism

Advanced Science, EarlyView.
Compartmentalized lactate signaling provides a spatial framework for understanding how lactate‐rich states are generated, transported, sensed, and translated into biological outputs. This Review integrates extracellular, cytosolic, mitochondrial‐associated, and nuclear lactate mechanisms to explain how lactate shapes metabolic adaptation, immune ...
Han Wang, Si‐Yuan Yang, Wei Xu
wiley   +1 more source

A dual-enzyme-like nanozyme adjuvant alleviates tumor hypoxia to enhance photothermally ferroptosis-immune synergistic tumor therapy. [PDF]

Mater Today Bio
Chang P, Chen D, Yang X, Tian K, Liu Y, Li K, Chen D, Wang W, Pan Q, Zeng Y, Zhan Y, Zhan W.   +11 more
europepmc   +1 more source