Results 21 to 30 of about 267,863 (253)

Isolation of Mononuclear Cell Populations from Ovarian Carcinoma Ascites

Bio-Protocol, 2017
Ovarian cancer is one of the most fatal tumors in women. Due to a lack of symptoms and adequate screening methods, patients are diagnosed at advanced stages with extensive tumor burden (Jelovac and Armstrong, 2011).
Christina Wefers, Ghaith Bakdash, Meritxell Moreno Martin, Tjitske Duiveman-de Boer, Ruurd Torensma, Leon Massuger, I Jolanda de Vries   +6 more
doaj   +1 more source

Tumor-associated macrophages promote intratumoral conversion of conventional CD4+ T cells into regulatory T cells via PD-1 signalling

OncoImmunology, 2022
While regulatory T cells (Tregs) and macrophages have been recognized as key orchestrators of cancer-associated immunosuppression, their cellular crosstalk within tumors has been poorly characterized.
Kevin Kos, Camilla Salvagno, Max D. Wellenstein, Muhammad A. Aslam, Denize A. Meijer, Cheei-Sing Hau, Kim Vrijland, Daphne Kaldenbach, Elisabeth A.M. Raeven, Martina Schmittnaegel, Carola H. Ries, Karin E. de Visser   +11 more
doaj   +1 more source

Immunologic Treatment of Tumors.

Experimental Biology and Medicine, 1959
SummaryWe produced antibodies by injecting cancer cells obtained from Walker 256 tumor into rabbits; after several injections of the cell antigen, the rabbits were exsanguinated, and the serum fractionated. Antibodies to normal tissue were adsorbed out by exposure to normal tissue.
J A, McCREDIE, E R, BROWN, W H, COLE
openaire   +2 more sources

CART cells are prone to Fas- and DR5-mediated cell death

Journal for ImmunoTherapy of Cancer, 2018
Adoptive transfer of T cells transduced with Chimeric Antigen Receptors (CAR) are now FDA-approved for the treatment of B-cell malignancies. Yet, the functionality of the endogenous TCR in CART cells has not been fully assessed. Here, we demonstrate that
Benjamin O. Tschumi, Nina Dumauthioz, Bastien Marti, Lianjun Zhang, Pascal Schneider, Jean-Pierre Mach, Pedro Romero, Alena Donda   +7 more
doaj   +1 more source

Isolation of native EVs from primary biofluids—Free‐flow electrophoresis as a novel approach to purify ascites‐derived EVs

Journal of Extracellular Biology, 2022
Although extracellular vesicles (EVs) have been extensively characterized, efficient purification methods, especially from primary biofluids, remain challenging. Here we introduce free‐flow electrophoresis (FFE) as a novel approach for purifying EVs from
Christian Preußer, Kathrin Stelter, Tobias Tertel, Manuel Linder, Frederik Helmprobst, Witold Szymanski, Johannes Graumann, Bernd Giebel, Silke Reinartz, Rolf Müller, Gerhard Weber, Elke Pogge vonStrandmann   +11 more
doaj   +1 more source

Targeted blocking of CCR2 and CXCR2 improves the efficacy of transarterial chemoembolization of hepatocarcinoma

Cancer Cell International, 2022
Background Transarterial chemoembolization (TACE) has been shown to prolong survival in patients with unresectable hepatocellular carcinoma (HCC); however, the long-term survival remains dismal.
Zhiqiang Tian, Xiaojuan Hou, Wenting Liu, Changchun Shao, Lu Gao, Jinghua Jiang, Li Zhang, Zhipeng Han, Lixin Wei   +8 more
doaj   +1 more source

Inflammation and lymphocyte infiltration are associated with shorter survival in patients with high-grade glioma

OncoImmunology, 2020
Glioma represents a serious health burden in terms of morbidity and mortality. The prognostic significance of the lymphoid and myeloid infiltrates in glioma is not clearly determined.
Eliana Marinari, Mathilde Allard, Robin Gustave, Valérie Widmer, Géraldine Philippin, Doron Merkler, Petros Tsantoulis, Valérie Dutoit, Pierre-Yves Dietrich   +8 more
doaj   +1 more source

Misperception of Body Weight After Childhood Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Misperception of body weight can negatively impact the weight management efforts of childhood cancer survivors (CCSs). Both being overweight or underweight are associated with chronic health conditions commonly observed in CCS; therefore, accurate weight perception is critical for reducing long‐term health risks.
Fabiën N. Belle, Tomáš Sláma, Eva Haegler‐Laube, Reto D. Kurmann, Gabriela M. Kuster, Christoph Saner, Eva Scheler, Yara Shoman, Christina Schindera   +8 more
wiley   +1 more source

Tumor-associated macrophages display differential protein cargo sorting in extracellular vesicles associated with poor survival in ovarian cancer

Molecular Medicine
Ovarian cancer (OC) progression and metastasis are promoted by ascites, which constitutes a central part of the tumor microenvironment (TME). In this fluid, tumor-associated macrophages (TAMs) represent a prominent immune cell type.
Johanna Pörschke, Sophie Heidemann, Hannah P. Nehring, Aina Lluch, Witold Szymański, Florian Finkernagel, Christian Preußer, Aditya M. Bhagwat, Timm J. Stamm, Leah Sommerfeld, Frederik Helmprobst, Rolf Müller, Silke Reinartz, Johannes Graumann, Elke Pogge von Strandmann, María Gómez-Serrano   +15 more
doaj   +1 more source

Newly developed 3D in vitro models to study tumor–immune interaction

Journal of Experimental & Clinical Cancer Research, 2023
Immunotherapy as a rapidly developing therapeutic approach has revolutionized cancer treatment and revitalized the field of tumor immunology research. 3D in vitro models are emerging as powerful tools considering their feature to maintain tumor cells in ...
Peiyuan Mu, Shujuan Zhou, Tao Lv, Fan Xia, Lijun Shen, Juefeng Wan, Yaqi Wang, Hui Zhang, Sanjun Cai, Junjie Peng, Guoqiang Hua, Zhen Zhang   +11 more
doaj   +1 more source