Results 31 to 40 of about 265,672 (255)

Immunologic Treatment of Tumors.

Experimental Biology and Medicine, 1959
SummaryWe produced antibodies by injecting cancer cells obtained from Walker 256 tumor into rabbits; after several injections of the cell antigen, the rabbits were exsanguinated, and the serum fractionated. Antibodies to normal tissue were adsorbed out by exposure to normal tissue.
J A, McCREDIE, E R, BROWN, W H, COLE
openaire   +2 more sources

Isolation of native EVs from primary biofluids—Free‐flow electrophoresis as a novel approach to purify ascites‐derived EVs

Journal of Extracellular Biology, 2022
Although extracellular vesicles (EVs) have been extensively characterized, efficient purification methods, especially from primary biofluids, remain challenging. Here we introduce free‐flow electrophoresis (FFE) as a novel approach for purifying EVs from
Christian Preußer, Kathrin Stelter, Tobias Tertel, Manuel Linder, Frederik Helmprobst, Witold Szymanski, Johannes Graumann, Bernd Giebel, Silke Reinartz, Rolf Müller, Gerhard Weber, Elke Pogge vonStrandmann   +11 more
doaj   +1 more source

CART cells are prone to Fas- and DR5-mediated cell death

Journal for ImmunoTherapy of Cancer, 2018
Adoptive transfer of T cells transduced with Chimeric Antigen Receptors (CAR) are now FDA-approved for the treatment of B-cell malignancies. Yet, the functionality of the endogenous TCR in CART cells has not been fully assessed. Here, we demonstrate that
Benjamin O. Tschumi, Nina Dumauthioz, Bastien Marti, Lianjun Zhang, Pascal Schneider, Jean-Pierre Mach, Pedro Romero, Alena Donda   +7 more
doaj   +1 more source

Targeted blocking of CCR2 and CXCR2 improves the efficacy of transarterial chemoembolization of hepatocarcinoma

Cancer Cell International, 2022
Background Transarterial chemoembolization (TACE) has been shown to prolong survival in patients with unresectable hepatocellular carcinoma (HCC); however, the long-term survival remains dismal.
Zhiqiang Tian, Xiaojuan Hou, Wenting Liu, Changchun Shao, Lu Gao, Jinghua Jiang, Li Zhang, Zhipeng Han, Lixin Wei   +8 more
doaj   +1 more source

Inflammation and lymphocyte infiltration are associated with shorter survival in patients with high-grade glioma

OncoImmunology, 2020
Glioma represents a serious health burden in terms of morbidity and mortality. The prognostic significance of the lymphoid and myeloid infiltrates in glioma is not clearly determined.
Eliana Marinari, Mathilde Allard, Robin Gustave, Valérie Widmer, Géraldine Philippin, Doron Merkler, Petros Tsantoulis, Valérie Dutoit, Pierre-Yves Dietrich   +8 more
doaj   +1 more source

Newly developed 3D in vitro models to study tumor–immune interaction

Journal of Experimental & Clinical Cancer Research, 2023
Immunotherapy as a rapidly developing therapeutic approach has revolutionized cancer treatment and revitalized the field of tumor immunology research. 3D in vitro models are emerging as powerful tools considering their feature to maintain tumor cells in ...
Peiyuan Mu, Shujuan Zhou, Tao Lv, Fan Xia, Lijun Shen, Juefeng Wan, Yaqi Wang, Hui Zhang, Sanjun Cai, Junjie Peng, Guoqiang Hua, Zhen Zhang   +11 more
doaj   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Tumor-associated macrophages display differential protein cargo sorting in extracellular vesicles associated with poor survival in ovarian cancer

Molecular Medicine
Ovarian cancer (OC) progression and metastasis are promoted by ascites, which constitutes a central part of the tumor microenvironment (TME). In this fluid, tumor-associated macrophages (TAMs) represent a prominent immune cell type.
Johanna Pörschke, Sophie Heidemann, Hannah P. Nehring, Aina Lluch, Witold Szymański, Florian Finkernagel, Christian Preußer, Aditya M. Bhagwat, Timm J. Stamm, Leah Sommerfeld, Frederik Helmprobst, Rolf Müller, Silke Reinartz, Johannes Graumann, Elke Pogge von Strandmann, María Gómez-Serrano   +15 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Huwe1 supports B-cell development, B-cell-dependent immunity, somatic hypermutation and class switch recombination by regulating proliferation

Frontiers in Immunology, 2023
The development and differentiation of B cells is intimately linked to cell proliferation and the generation of diverse immunoglobulin gene (Ig) repertoires.
Aldo Spanjaard, Maria Stratigopoulou, Daniël de Groot, Muhammad Aslam, Paul C. M. van den Berk, Chantal Stappenbelt, Matilda Ayidah, Joyce J. I. Catsman, Iris N. Pardieck, Maaike Kreft, Ramon Arens, Jeroen E. J. Guikema, Heinz Jacobs   +12 more
doaj   +1 more source