Results 51 to 60 of about 3,216,819 (320)
Medical Immunology, 2018 The immune system has effectively evolved to protect the host against foreign invaders, including bacterial, viral, and parasitic infiltrates. Less clear has been the interaction and the protective effects the immune system mounts against its own ...
Rachel L. G. Maus +2 more
semanticscholar +1 more source
Transcription factors in fibroblast plasticity and CAF heterogeneity
Journal of Experimental & Clinical Cancer Research, 2023 In recent years, research focused on the multifaceted landscape and functions of cancer-associated fibroblasts (CAFs) aimed to reveal their heterogeneity and identify commonalities across diverse tumors for more effective therapeutic targeting of pro ...
Roberta Melchionna +4 more
doaj +1 more source
Modulation of SLFN11 induces changes in DNA Damage response in breast cancer
Cancer Cell International, 2023 Background Lack of Schlafen family member 11 (SLFN11) expression has been recently identified as a dominant genomic determinant of response to DNA damaging agents in numerous cancer types.
Christophe Michel Raynaud +13 more
doaj +1 more source
OncoImmunology, 2022 While regulatory T cells (Tregs) and macrophages have been recognized as key orchestrators of cancer-associated immunosuppression, their cellular crosstalk within tumors has been poorly characterized.
Kevin Kos +11 more
doaj +1 more source
Isolation of Mononuclear Cell Populations from Ovarian Carcinoma Ascites
Bio-Protocol, 2017 Ovarian cancer is one of the most fatal tumors in women. Due to a lack of symptoms and adequate screening methods, patients are diagnosed at advanced stages with extensive tumor burden (Jelovac and Armstrong, 2011).
Christina Wefers +6 more
doaj +1 more source
Journal of Extracellular Biology, 2022 Although extracellular vesicles (EVs) have been extensively characterized, efficient purification methods, especially from primary biofluids, remain challenging. Here we introduce free‐flow electrophoresis (FFE) as a novel approach for purifying EVs from
Christian Preußer +11 more
doaj +1 more source
CART cells are prone to Fas- and DR5-mediated cell death
Journal for ImmunoTherapy of Cancer, 2018 Adoptive transfer of T cells transduced with Chimeric Antigen Receptors (CAR) are now FDA-approved for the treatment of B-cell malignancies. Yet, the functionality of the endogenous TCR in CART cells has not been fully assessed. Here, we demonstrate that
Benjamin O. Tschumi +7 more
doaj +1 more source
Immunological ignorance of solid tumors [PDF]
Springer Seminars in Immunopathology, 2005 Many peripheral solid tumors such as sarcomas and carcinomas express tumor-specific antigens that can serve as targets for immune effector T cells. Nevertheless, the immune surveillance against clinically manifest carcinomas and sarcomas seems relatively inefficient.
Adrian F. Ochsenbein +1 more
openaire +4 more sources
Cancer Cell International, 2022 Background Transarterial chemoembolization (TACE) has been shown to prolong survival in patients with unresectable hepatocellular carcinoma (HCC); however, the long-term survival remains dismal.
Zhiqiang Tian +8 more
doaj +1 more source
Tumor microenvironment and immunology of cholangiocarcinoma
Hepatoma Research, 2022 Cholangiocarcinoma (CCA), an aggressive tumor originating from both intra- and extra-hepatic biliary cells, represents an unmet need in liver oncology, as treatment remains largely unsatisfactory. A typical feature of CCA is the presence of a complex tumor microenvironment (TME) composed of neoplastic cells, a rich inflammatory infiltrate, and cancer ...
Cadamuro M. +3 more
openaire +2 more sources