Results 91 to 100 of about 343,340 (395)

Regulatory T cells with multiple suppressive and potentially pro-tumor activities accumulate in human colorectal cancer [PDF]

, 2016
Tregs can contribute to tumor progression by suppressing antitumor immunity. Exceptionally, in human colorectal cancer (CRC), Tregs are thought to exert beneficial roles in controlling pro-tumor chronic inflammation.
BARNABA, Vincenzo, CARONNA, Roberto, CHIRLETTI, Piero, CIARDI, Antonio, DEL BENE, GABRIELLA, FARELLI, FRANCESCO, Focaccetti, Chiara, Longo, Flavia, MORELLI, Sergio, PACELLA, ILENIA, PICONESE, SILVIA, SACCO, LUCA, SCHINZARI, VALERIA, TIMPERI, ELEONORA, VESTRI, Anna Rita   +14 more
core   +1 more source

Prognostic value of tumor-infiltrating lymphocytes in patients with triple-negative breast cancer: a systematic review and meta-analysis

BMC Cancer, 2019
The objective of this systematic review and meta-analysis was to determine the prognostic value of total tumor-infiltrating lymphocytes (TILs) and subtypes of TILs (CD4+, CD8+, and FOXP3+) in triple-negative breast cancer (TNBC).
G. Gao, Zi-Han Wang, X. Qu, Zhongtao Zhang   +3 more
semanticscholar   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Joint and individual analysis of breast cancer histologic images and genomic covariates [PDF]

, 2020
A key challenge in modern data analysis is understanding connections between complex and differing modalities of data. For example, two of the main approaches to the study of breast cancer are histopathology (analyzing visual characteristics of tumors ...
Calhoun, Benjamin C., Carmichael, Iain, Couture, Heather D., Geradts, Joseph, Hannig, Jan, Hoadley, Katherine A., Marron, J. S., Niethammer, Marc, Olsson, Linnea, Perou, Charles M., Troester, Melissa A.   +10 more
core   +3 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Advances in tumor-infiltrating B lymphocytes

Central European Journal of Immunology
In the landscape of tumor immunotherapy, T cell-mediated immune responses have consistently captured the attention, while the contributions of B cells have been neglected.
Yule Zhang, Ming Huang, Jinxiu Chen, Chunyu Cao, Hongyan Wu   +4 more
doaj   +1 more source

P8‐59: Drebrin‐positive tumor‐infiltrating lymphocytes as a prognostic biomarker for lung squamus cell carcinoma [PDF]

, 2021
S. Sakamoto, Kazuhiro Sato, Satoshi Goshima, Ruriko Asahi, Yuri Takita, Eiki Omoto, Yuka Izumiya, Naho Kumagai, Yukiyasu Hasegawa, Hayato Yokota, Yūji Okuda, Mariko Asano, Yumiko Akamine, Masahide Takeda, Masatomo Miura, Kastutoshi Nakayama, Kosuke Imamura, Yusuke Tomita, Ryo Sato, Tokunori Ikeda, Shinji Iyama, Yoshihiko Goto, Moriyasu Anai, Takayuki Jodai, Shinya Sakata, Koichi Saruwatari, Sho Saeki, Koei Ikeda, Makoto Suzuki, Takuro Sakagami   +29 more
openalex   +1 more source

Prognostic Value of Tumor-Infiltrating Lymphocytes in Head and Neck Squamous Cell Carcinoma.

JAMA Otolaryngology - Head and Neck Surgery, 2019
Importance Biomarkers that reflect prognosis and cellular immunity in patients with head and neck squamous cell carcinoma (HNSCC) are a prerequisite for improving individualized treatment that limits the intensity and morbidity of conventional treatment ...
M. Spector, E. Bellile, Lahin M. Amlani, Katie R. Zarins, Joshua D Smith, J. Brenner, L. Rozek, Ariane Nguyen, Daffyd G. Thomas, J. Mchugh, Jeremy M. G. Taylor, G. Wolf, Neck Spore Program   +12 more
semanticscholar   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Intratumoral immune cells expressing PD-1/PD-L1 and their prognostic implications in cancer: a meta-analysis

The International Journal of Biological Markers, 2018
Background: The prognostic value of immune cells expressing programmed cell death 1 (PD-1) and PD-1 ligand 1 (PD-L1) in cancer are controversial, and the potential differential impact of using tissue microarrays and whole tissue sections to assess the ...
Younghoon Kim, Xianyu Wen, Nam Yun Cho, Gyeong Hoon Kang   +3 more
doaj   +1 more source