Results 321 to 330 of about 267,145 (352)

Tumor-infiltrating lymphocytes: A new hope

Cancer Cell
Tumor-infiltrating lymphocytes (TILs) can be massively expanded from resected tumors and used as a cellular treatment for advanced malignancies. TILs require a preparative non-myeloablative chemotherapy followed by an abbreviated course of interleukin-2.
Amod A, Sarnaik, Patrick, Hwu, James J, Mulé, Shari, Pilon-Thomas   +3 more
openaire   +2 more sources

Expansion of Tumor-Infiltrating Lymphocytes from Melanoma Tumors

2019
Autologous, in vitro-expanded tumor-infiltrating lymphocytes (TIL) have been successfully used for treatment of melanoma patients. Expansion of TIL from tumors is usually performed in two steps. The details of the procedure differ between different laboratories, but the general concept remains the same. In the first step, small fragments of a tumor are
Tanja Lövgren, Tanja Lövgren, Stina L. Wickström   +2 more
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Immunoresponse of Tissue Infiltrating Lymphocytes in Bladder Tumors

Journal of Urology, 1989
Local immunocompetence was evaluated immunohistochemically in patients with bladder tumors before and after local injections of an immunomodulator. The subpopulations of tissue infiltrating lymphocytes (TIL) were examined by staining six serial sections with Leu4, Leu7, Leu10, LeuM3, OKT4, and OKT8 antibodies. T cells predominated over B cells in 19 of
Hisao Matsuda, Takahiro Akiyama, Hironori Tsujihashi, Takashi Kurita, Shigeya Uejima   +4 more
openaire   +3 more sources

Predictors of Tumor-Infiltrating Lymphocyte Efficacy in Melanoma

Immunotherapy, 2015
In the past decades, the increasing knowledge in cellular immunology and tumor-host immune interactions, led to the development of immunotherapy approaches. Immunotherapy, based on adoptive cell transfer of ex vivo activated and expanded tumor-infiltrating T lymphocytes (TILs), has shown promising clinical results in patients with metastatic melanoma ...
Michal J. Besser, Michal J. Besser, Jacob Schachter, Dragoslav Zikich   +3 more
openaire   +3 more sources

Immunopriming of Tumor Infiltrating Lymphocytes with Neoadjuvant Cyclophosphamide

Immunological Investigations, 1993
Tumor infiltrating lymphocytes (TIL) are increasingly employed in immunotherapy protocols. When modified and expanded they can be utilized in new therapeutic protocols. TIL augmentation can be in vitro and in vivo. The purpose of this article is to review the various methods of TIL augmentation and report our experience with a neoadjuvant technique of ...
M. Rubenstein, M. Shaw, P. Guinan
openaire   +3 more sources

Tumor-infiltrating Lymphocytes and Prognosis of Hepatocellular Carcinoma

Japanese Journal of Clinical Oncology, 1992
Tumor-infiltrating lymphocytes (TIL) were isolated from 17 human hepatocellular carcinomas (HCC). The proliferation of TIL cultured with recombinant interleukin-2 (rIL-2) was evaluated. We also examined prognosis in relation to TIL. Successful expansion of TIL was achieved in 16 of the 17 lesions.
Hiroshi Kobayashi, Yoshie Une, Masuo Hosokawa, Akira Kawata, Junichi Uchino   +4 more
openaire   +3 more sources

Tumor-Infiltrating Lymphocytes and Their Role in Solid Tumor Progression

2013
Tumor-infiltrating lymphocytes (TIL) are an important component of the tumor environment. Their role in tumor growth and progression has been debated for decades. Today, emphasis has shifted to beneficial effects of TIL for the host and to therapies optimizing the benefits by reducing immune suppression in the tumor microenvironment. Evidence indicates
openaire   +3 more sources

Multiparametric analysis of tumor infiltrating lymphocytes in solid tumors

The use of single-cell technologies in characterizing the interactions between immune and cancer cells is in continuous expansion. Indeed, the combination of different single-cell approaches enables the definition of novel phenotypic and functional aspects of the immune cells infiltrating the tumor microenvironment (TME). This approach is promoting the
Borella R., Paolini A., Aramini B., Gibellini L., Masciale V., Lo Tartaro D., Dominici M., De Biasi S., Cossarizza A.   +8 more
openaire   +3 more sources

TUMOR INFILTRATING LYMPHOCYTES*

Annals of the New York Academy of Sciences, 1976
Eva Klein, Farkas VEaAnky, Susanne Becker, Mikael Jondal, Erik Svedmyr   +4 more
openaire   +3 more sources

Separation and Characteristics of Tumor-Infiltrating Lymphocytes in Man

1980
During the initial phase of tumor immunology, when experiments were conducted with syngeneic systems, without the involvement of reactivities against histocompatibility antigens, the accumulation of important information was explosive. As usual with accumulating knowledge, the number of unanswered questions increased.
M. Fopp, Uri Galili, Farkas Vánky, Eva Klein, B. M. Vose   +4 more
openaire   +3 more sources