Results 61 to 70 of about 5,023,895 (307)

Complex Pediatric Neuroblastoma Presenting With Superior Vena Cava Syndrome, Tumor Lysis, and Massive Pleural Effusion

Indonesian Journal of Cancer
Background: The simultaneous presence of superior vena cava syndrome, tumor lysis syndrome, massive pleural effusion, and metabolic syndrome in a child with mediastinal neuroblastoma is exceedingly rare and sparsely described in the literature.
Maya Novariza, Sri Mulatsih, MD, PhD, Pudjo Hagung Widjajanto, Alexandra Pangarso, Dito Pondra Dharma, Aulia Suluk Brilliant Sumpono, Yunanto Kurnia, Clements Nicodhemus Garuda Nagara   +7 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Hypercalcemia in Tumor Lysis Syndrome [PDF]

Indian Journal of Hematology and Blood Transfusion, 2013
Tumor lysis syndrome (TLS) is characterized by hyperkalemia, hyperuricemia, hypocalcemia and hyperphosphatemia. This report describes a case of hypercalcemia in TLS in a patient with diffuse large B cell lymphoma.
openaire   +2 more sources

Spontaneous Tumor Lysis Syndrome in an Adenocarcinoma of Unknown Origin. [PDF]

, 2020
Spontaneous tumor lysis syndrome (STLS) is a rare oncologic emergency caused by massive cancer cell lysis or necrosis without a precipitating factor. Although tumor lysis syndrome (TLS) is most commonly associated with hematologic malignancies, a small ...
Willing, Tyler, DO, Allen, Jamie, DO, Kalter, Joshua A, MS3, Evans, Elizabeth M, DO, Yang, Yuchen, DO   +4 more
core   +1 more source

Modification of H-2 Antigenic Sites by Enzymatic Treatment Influences Virus-Specific Target Cell Lysis [PDF]

, 1976
Vaccinia virus-infected cells were treated enzymatically to remove H-2 antigenic sites. The effect of this procedure on virus-specific cell-mediated cytolysis (CMC) and virus-specific antibody-mediated cytolysis (AMC) was tested. Due to the inhibition of
Ertl, H C, Koszinowski, Ulrich H., Koszinowski, U H, Ertl, H.   +3 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Tumor Lysis Syndrome in Chronic Lymphocytic Leukemia with Novel Targeted Agents

The Oncologist, 2017
Tumor lysis syndrome is an uncommon but potentially life‐threatening complication associated with the treatment of some cancers. In this review, prevention strategies and management of patients with chronic lymphocytic leukemia who develop tumor lysis ...
B. Cheson, Sari L. Heitner Enschede, E. Cerri, Monali Desai, J. Potluri, N. Lamanna, C. Tam   +6 more
semanticscholar   +1 more source

From skin to spontaneous lysis: A case of spontaneous tumor lysis syndrome in metastatic melanoma

, 2017
Tumor lysis syndrome is a life-threatening complication that often occurs after administration of cytotoxic therapy, but rarely occurs spontaneously without chemotherapy.
Mark H Holguin, Jon Herrington, Susan Seago, Charis G Durham, Chelsea Williams   +4 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

An unseen ′face′ of hyperkalemia

Journal of the Scientific Society, 2013
Hyperkalemia with normal or minimal electrocardiogram (ECG) changes is not commonly encountered. The ′milder′ presentation may mask and hence lead to an under-management of a severe hyperkalemia.
Dilip Gude, Aslam Abbas
doaj   +1 more source