Results 21 to 30 of about 150,813 (294)
IJU Case Reports, 2019 Introduction Tumor lysis syndrome is a rare and potentially fatal complication of oncological treatment. It is characterized by biochemical changes associated with the rapid lysis of malignant cells, usually after chemotherapy.
Masashi Oshima +7 more
doaj +1 more source
CRAF R391W is a melanoma driver oncogene. [PDF]
, 2016 Approximately 75% of melanomas have known driver oncogenic mutations in BRAF, NRAS, GNA11 or GNAQ, while the mutations providing constitutive oncogenic signaling in the remaining melanomas are not known.
Atefi, Mohammad +11 more
core +3 more sources
Sorafenib-induced tumor lysis syndrome in a patient with metastatic hepatocellular carcinoma ☆
Hematology/Oncology and Stem Cell Therapy, 2020 Tumor lysis syndrome is a potentially lethal complication of chemotherapy, usually associated with aggressive hematologic malignancies. We describe the case of a young patient with metastatic hepatocellular cancer who developed rapid and fatal tumor ...
Sardar Zakariya Imam +2 more
doaj +1 more source
Mutations in the PKM2 exon-10 region are associated with reduced allostery and increased nuclear translocation. [PDF]
, 2019 PKM2 is a key metabolic enzyme central to glucose metabolism and energy expenditure. Multiple stimuli regulate PKM2's activity through allosteric modulation and post-translational modifications.
Chen, Tsan-Jan +11 more
core +3 more sources
Case Reports in Gastroenterology, 2020 Tumor lysis syndrome (TLS) is a potentially life-threatening complication of chemotherapy. It usually occurs in rapidly proliferating hematological malignancies. TLS is deemed spontaneous (STLS) when it occurs prior to any cytotoxic or definite treatment.
Inna Shaforostova +4 more
doaj +1 more source
Journal of Cancer Research and Practice, 2016 Tumor lysis syndrome in solid tumors is a rare occurrence, with a poor prognosis. We present the case of a patient of recurrent colon cancer who received chemotherapy with FOLFOX regimen (lencovorin, fluorouracil, and oxaliplatin) with subsequent tumor ...
Ruo-Han Tseng +4 more
doaj +1 more source
JAAPA, 2021 ABSTRACT Tumor lysis syndrome (TLS) is one of the most common oncologic emergencies, occurring when tumor cell contents are rapidly released into the bloodstream. This release of cellular contents, including uric acid, phosphate, and potassium, can rapidly overwhelm the body's homeostasis mechanisms, leading to renal failure, seizures ...
openaire +3 more sources
Acute tumor lysis syndrome after proximal splenic artery embolization
Radiology Case Reports, 2016 Preoperative splenic artery embolization for massive splenomegaly has been shown to reduce intraoperative hemorrhage during splenectomy. We describe a case of tumor lysis syndrome after proximal splenic artery embolization in a patient with advanced ...
Jason T. Salsamendi +4 more
doaj +1 more source
Spontaneous Tumor Lysis Syndrome
Journal of Investigative Medicine High Impact Case Reports, 2015 Tumor lysis syndrome (TLS) is a known complication of malignancy and its treatment. The incidence varies on malignancy type, but is most common with hematologic neoplasms during cytotoxic treatment. Spontaneous TLS is thought to be rare.
Alicia C. Weeks MD +1 more
doaj +1 more source
A requirement for STAG2 in replication fork progression creates a targetable synthetic lethality in cohesin-mutant cancers. [PDF]
, 2019 Cohesin is a multiprotein ring that is responsible for cohesion of sister chromatids and formation of DNA loops to regulate gene expression. Genomic analyses have identified that the cohesin subunit STAG2 is frequently inactivated by mutations in cancer.
Ashworth, Alan +4 more
core +2 more sources