Results 101 to 110 of about 3,561,070 (402)

Tumor stiffness extends its grip on the metastatic microenvironment [PDF]

, 2017
The increased stiffness of a tumor triggers a multitude of responses that aid cancer cell dissemination. Stiffness-induced expression of CCN1 mediates autocrine signaling in the endothelium to upregulate N-Cadherin levels.
Reid, Steven E., Zanivan, Sara
core   +2 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Complexity in cancer stem cells and tumor evolution: towards precision medicine [PDF]

, 2017
In this review, we discuss recent advances on the plasticity of cancer stem cells and highlight their relevance to understand the metastatic process and to guide therapeutic interventions.
La Porta, Caterina A. M., Zapperi, Stefano   +1 more
core   +2 more sources

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Niche inheritance: a cooperative pathway to enhance cancer cell fitness though ecosystem engineering [PDF]

, 2014
Cancer cells can be described as an invasive species that is able to establish itself in a new environment. The concept of niche construction can be utilized to describe the process by which cancer cells terraform their environment, thereby engineering ...
Barar J, Elton CS, Faraji F, Fidler IJ, Folkman J, Gatenby RA, Healy M, Hutchinson GE, Odling‐Smee FJ, Odling‐Smee FJ, Paget S, Pienta KJ, Weiss L, Wey JS   +13 more
core   +2 more sources

MiR‐192/NKRF axis confers lung cancer cell chemoresistance to cisplatin via the NF‐κB pathway

Thoracic Cancer, 2022
Background Chemoresistance influences the therapeutic effect of cisplatin and remains a major obstacle to its clinical use. MicroRNAs are associated with drug resistance of various tumors.
Yang Li, Lingling Zu, Heng Wu, Fang Zhang, Yaguang Fan, Hongli Pan, Xinxin Du, Fengjie Guo, Qinghua Zhou   +8 more
doaj   +1 more source

Redefining Tumor-Associated Macrophage Subpopulations and Functions in the Tumor Microenvironment

Frontiers in Immunology, 2020
The immunosuppressive status of the tumor microenvironment (TME) remains poorly defined due to a lack of understanding regarding the function of tumor-associated macrophages (TAMs), which are abundant in the TME.
Kaiyue Wu, K. Lin, Xiaoyang Li, Xiangliang Yuan, Peiqing Xu, Peihua Ni, Dakang Xu   +6 more
semanticscholar   +1 more source

Targeting hypoxic tumor microenvironment in pancreatic cancer

Journal of Hematology & Oncology, 2021
Attributable to its late diagnosis, early metastasis, and poor prognosis, pancreatic cancer remains one of the most lethal diseases worldwide. Unlike other solid tumors, pancreatic cancer harbors ample stromal cells and abundant extracellular matrix but ...
Jinxin Tao, Gang Yang, Wenchuan Zhou, J. Qiu, Guangyu Chen, W. Luo, F. Zhao, L. You, Lianfang Zheng, Taiping Zhang, Yupei Zhao   +10 more
semanticscholar   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

ALKBH5 regulates anti–PD-1 therapy response by modulating lactate and suppressive immune cell accumulation in tumor microenvironment

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance N6-methylation of adenosine (m6A) RNA modification plays important roles in development and tumorigenesis. The functions and mechanisms of m6A demethylases during cancer immunotherapy is still unclear.
Na Li, Yuqi Kang, Ling-Zen Wang, S. Huff, Rachel Tang, Hui Hui, Kriti Agrawal, G. Gonzalez, Yinsheng Wang, S. Patel, T. Rana   +10 more
semanticscholar   +1 more source