Results 171 to 180 of about 3,534,255 (422)

Neoadjuvant sipuleucel-T induces both Th1 activation and immune regulation in localized prostate cancer. [PDF]

, 2019
Sipuleucel-T is the only FDA-approved immunotherapy for metastatic castration-resistant prostate cancer. The mechanism by which this treatment improves survival is not fully understood.
Chan, Stephen, Fong, Lawrence, Hagihara, Katsunobu, Oh, David Y, Simko, Jeffry, Wei, Xiao X, Zhang, Li   +6 more
core  

Prostaglandins and Gangliosides of Tumor Microenvironment: Their Role in Angiogenesis [PDF]

, 1995
Pietro M. Gullino
openalex   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

The mRNA-edited form of GABRA3 suppresses GABRA3-mediated Akt activation and breast cancer metastasis

Nature Communications, 2016
GABRA3, a subunit of the GABA receptor, is often highly expressed in brain metastasis and breast cancers. Here, the authors demonstrated that GABRA3 activates AKT to promote breast cancer cell invasion and that the A-to-I edited form of GABRA3 ...
Kiranmai Gumireddy, Anping Li, Andrew V. Kossenkov, Masayuki Sakurai, Jinchun Yan, Yan Li, Hua Xu, Jian Wang, Paul J. Zhang, Lin Zhang, Louise C. Showe, Kazuko Nishikura, Qihong Huang   +12 more
doaj   +1 more source

Pancreas Microenvironment Promotes VEGF Expression and Tumor Growth: Novel Window Models for Pancreatic Tumor Angiogenesis and Microcirculation [PDF]

, 2001
Yoshikazu Tsuzuki, Carla Mouta Carreira, Maximilian Bockhorn, Lei Xu, Rakesh K. Jain, Dai Fukumura   +5 more
openalex   +1 more source

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

GPR87 promotes invasion and migration through the RHO/ROCK pathway in non-small cell lung cancer

Shanghai Jiaotong Daxue xuebao. Yixue ban
Objective·To explore the role and molecular mechanism of GPR87 in regulating the invasion and migration of non-small cell lung cancer (NSCLC).Methods·Bioinformatics methods, including GEO, UALCAN, KM Plotter and other public database analysis platforms ...
LIU Chenxi, HAN Lin, YANG Yi, ZHOU Han, LIU Yayun, SHENG Deqiao   +5 more
doaj   +1 more source

COX inhibitors markedly enhance tumor radiosensitization of cultured human cancer cells under acidic microenvironment [PDF]

, 2001
Tushar R. Shah, Samuel Ryu, Jun Won Kim
openalex   +1 more source

Does Porphyromonas gingivalis truly inhibit the oral carcinogenesis?

Molecular Oncology, EarlyView.
 
Chen‐xi Li, Zhong‐cheng Gong
wiley   +1 more source

Metabolic programming and immune suppression in the tumor microenvironment.

Cancer Cell, 2023
Emily N. Arner, J. Rathmell
semanticscholar   +1 more source