Results 211 to 220 of about 652,201 (289)

Role of tumor microenvironment in regulator of tumor progression and immunotherapy. [PDF]

Discov Oncol
Zhou P.
europepmc   +1 more source

Copper–Collagen Interactions Regulate the Mechanical and Invasive Properties of Tumor Spheroids

Advanced Healthcare Materials, EarlyView.
Ionic copper is investigated as a modulator of tumor spheroid growth and invasiveness in a 3D microfluidic glioblastoma model. Copper exposure alters metabolic activity, cytoskeletal organization, protrusion dynamics, and EMT‐related phenotypes in a dose‐ and timing‐dependent manner, revealing how copper bioavailability shapes tumor aggressiveness ...
Paula Guerrero‐López, Jose I. Garcia‐Peiro, Felipe Hornos, Jose L. Hueso, Jesus Santamaria, J. Manuel Garcia‐Aznar   +5 more
wiley   +1 more source

Association of Circulating T Cell and Tumor Microenvironment Profiles with Immune Checkpoint Blockade Outcomes in Sarcoma. [PDF]

Clin Cancer Res
Rosenbaum E, Ehrich F, Yosofvand M, Bradic M, Lee J, Adamow M, Movva S, Kelly CM, Avutu V, Banks LB, Chan JE, Chi P, Dickson MA, Gounder MM, Keohan ML, Maki RG, Reed DR, Fuentes P, Collins P, Desir R, Reiner A, Baranov O, Chernyshov K, Kotlov N, Subramanian A, Moding EJ, Qin LX, Wong P, Tap WD, Antonescu CR, Panageas KS, Shen R, D'Angelo SP.   +32 more
europepmc   +1 more source

Macrophage Membrane‐Cloaked, ROS‐Triggered Quercetin Nanocarriers Target Ovarian Lesions to Treat Polycystic Ovary Syndrome

Advanced Healthcare Materials, EarlyView.
The synthesis process of MM@PCD@QNPs and its potential mechanism for treating PCOS. (A) Assembly steps of MM@PCD@QNPs. (B) Synthesis and decomposition of MM@PCD@QNPs. (C) Potential therapeutic mechanisms of MM@PCD@QNPs for PCOS. PCD, PABP conjugated with DEX polymer; QUR, quercetin; CDI, N, N′‐carbonyldiimidazole; DEX, dextran; PABP, 4‐(hydroxymethyl ...
Wenzhu Li, Yu Guan, Nan Song, Feng Zhang, Zhimin Deng, Tailang Yin, Yanbing Yang, João Conde, Wenyi Jin, Zhinang Yin   +9 more
wiley   +1 more source

Unveiling the myxofibrosarcoma tumor microenvironment: implications for immunotherapy. [PDF]

Front Immunol
Profumo C, Grassi M, Rigo V, Mascherini M, Monti P, Arcovito G, Anselmi G, Damele L, Timon G, Comandini D, Croce M.   +10 more
europepmc   +1 more source

Nanobody‐Conjugated Theranostic Prodrug Targeting αvβ3 Integrin Enables Precision Cancer Therapy With Real‐Time Imaging

Advanced Healthcare Materials, EarlyView.
The image shows a schematic form a nanobody‐conjugated theranostic prodrug (NBD) platform targeting tumor‐associated αvβ3 integrin. The NBD system integrates selective nanobody‐mediated tumor recognition, glutathione‐responsive disulfide cleavage for doxorubicin release, and aza‐BODIPY‐based near‐infrared fluorescence for real‐time imaging.
Sanu Karan, Hyunseung Lee, Rema Naskar, Mi Young Cho, Hye Sun Park, Eun Hee Han, Soumyadip Hore, Sun Hee Cho, Truc Ngoc Kim Lam, Taewoong Son, Tae Jung Park, Inkyu Hwang, Jonathan L. Sessler, Kwan Soo Hong   +13 more
wiley   +1 more source

Unveiling the tumor microenvironment in colorectal cancer therapeutic resistance. [PDF]

Front Cell Dev Biol
Han J, Liang W, Li K.
europepmc   +1 more source

Common Signatures of Altered Gene Regulation and Invasiveness of Different Breast Cancer Cell Lines after Matrix Interface Crossing

Advanced Healthcare Materials, EarlyView.
Interface transmigration reprograms triple‐negative breast cancer cells, triggering a shared switch toward more aggressive and invasive phenotypes. Using a collagen I interface model, this study identifies shared transcriptional changes involving proliferation, chromatin remodeling, and DNA repair pathways.
Cornelia Clemens, Hannah Trampert, Nataliia Kotsiuba, Tilo Pompe   +3 more
wiley   +1 more source

An unexpected player in organ tropism: aspartate functions as signalling molecule to drive lung metastasis

Signal Transduction and Targeted Therapy
Felix C. E. Vogel, Almut Schulze
doaj   +1 more source

In Silico Analysis of the Dual Role of Tumor Microenvironment on Colon Cancer Subtypes. [PDF]

Cancer Inform
Kehinde C, Livesey M, Manganyi Y, Bendou H.   +3 more
europepmc   +1 more source