Results 221 to 230 of about 3,534,255 (422)

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Eighteenth Annual Pezcoller Symposium: Tumor Microenvironment and Heterotypic Interactions [PDF]

, 2006
Robert A. Weinberg, Enrico Mihich
openalex   +1 more source

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

FEBS Open Bio, EarlyView.
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli, Andrea Spinaci, Cui Chang, Rosaria Volpini, Catia Lambertucci, Matteo Landriscina, Vincenza Conteduca, Consuelo Amantini, Cristina Aguzzi, Laura Zeppa, Martina Giangrossi, Laura Soverchia, Matteo Santoni, Massimo Nabissi, Giorgio Santoni, Carlo Polidori   +15 more
wiley   +1 more source

T cells from the tumor microenvironment of patients with progressive myeloma can generate strong, tumor-specific cytolytic responses to autologous, tumor-loaded dendritic cells

, 2002
Madhav V. Dhodapkar, Joseph Krasovsky, Kara Olson   +2 more
openalex   +1 more source

MHC class I and class II molecules are expressed in both human and mouse prostate tumor microenvironment [PDF]

, 2006
Navreet K. Nanda, Lynn Birch, Norman M. Greenberg, Gail S. Prins   +3 more
openalex   +1 more source

Downregulation of O‐GlcNAcylation enhances etoposide‐induced p53‐mediated apoptosis in HepG2 human liver cancer cells

FEBS Open Bio, EarlyView.
Etoposide, a topoisomerase II inhibitor, reduces O‐GlcNAcylation in HepG2 liver cancer cells. Further inhibition of O‐GlcNAc transferase by OSMI‐1 enhanced etoposide‐induced apoptosis, lowering the IC50 for viability and increasing the EC50 for cytotoxicity.
Jaehoon Lee, Gi‐Bang Koo, Jihye Park, Byung‐Cheol Han, Mijin Kwon, Seung‐Ho Lee   +5 more
wiley   +1 more source

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

A approach of gastric conduit via the anterior of pulmonary hilum route during minimally invasive McKeown esophagectomy

Journal of Cardiothoracic Surgery
Background The gastric conduit is the most commonly used replacement organ for reconstruction after minimally invasive McKeown esophagectomy. Although the optimal route of gastric conduit remains controversial, the posterior mediastinal route is ...
Zhaoyang Yan, Xinjian Xu, Bin Guo, Pengzeng Wang, Linpeng Niu, Zhanjie Gao, Yusen Yuan, Fei Li, Ming He   +8 more
doaj   +1 more source

Nanoparticle design to induce tumor immunity and challenge the suppressive tumor microenvironment [PDF]

, 2014
Ali, Ali, Alnemri, Alshamsan, Anguille, Apetoh, Badie, Bal, Banciu, Becker, Belizaire, Benteyn, Blander, Bonehill, Breckpot, Broderick, Casares, Chang, Chiang, Clowes, Coley, Coulie, Cubillos-Ruiz, de Vries, Demento, Dominguez, Emeagi, Emeagi, Fernandez, Fischer, Fischer, Franklin, Gabrilovich, Giddam, Gooden, Gross, Gunzer, Haen, Hamzah, Harris, Heleen Dewitte, Henri, Hess, Hobbs, Hu, Huang, Huang, Huang, Humphries, Ilyinskii, Ine Lentacker, Ito, Jasani, Johansen, Kadowaki, Karine Breckpot, Kasturi, Kawakami, Kerkar, Kroemer, Kwong, Lake, Lakhani, Larocca, Larsson, Lee, Lee, Leuschner, Li, Li, Li, Liao, Lin, Lu, Luo, Lutz, Ma, Mantovani, Marchini, Matsumura, Matzinger, Matzinger, Melhem, Milicic, Moon, Motz, Mueller, Mukai, Nguyen, Nomura, Nordly, Nowak, Pardoll, Park, Perche, Perrie, Prabhakar, Pradere, Pradhan, Prasad, Puig-Kroger, Qin, Ray, Rein Verbeke, Rizwan, Roy, Roy, Sato, Schlosser, Schouppe, Sharp, She, Shimizu, Shortman, Simpson-Abelson, Singh, Singh, Slutter, Small, Smits, Stano, Stefaan C. De Smedt, Steinman, Su, Tacken, Tang, Tang, Tao, Temming, Thambi, van den Boorn, van der Most, Van Nuffel, Vanderbruggen, Villadangos, Villadangos, Vinogradov, Wang, Warburg, Wayteck, Wei, Wimmers, Wingender, Wong, Wydra, Yanasarn, Yoshizaki, Yu, Zaks, Zeisberger, Zhang, Zhao, Zhou, Zinkernagel   +153 more
core   +2 more sources

The role of circular RNAs in regulating cytokine signaling in cancer

FEBS Open Bio, EarlyView.
Cytokines present in the tumor microenvironment fuel cancer development. Aberrant expression of circRNAs contributes to cancer progression. Cytokines are involved in regulating circRNA biogenesis. Furthermore, aberrantly expressed circRNAs regulate the expression of ligands, receptors, and downstream effectors involved in cytokine signaling to promote ...
Vandana Joshi, Swati, Amit Mishra, Amaresh Panda, Vivek Sharma   +4 more
wiley   +1 more source