A Human‐Based Skin‐Lymphoreticular Model‐on‐Chip to Emulate Inflammatory Skin Conditions
Advanced Healthcare Materials, EarlyView.A human‐based lymphoreticular (LR) model was developed through guided self‐assembly and integrated in a skin‐lymphoreticular co‐culture in a microfluidic organ‐on‐chip to mimic interactions between skin and its draining lymph nodes. The human‐based skin‐lymphoreticular model resembles a minimally functional unit that allows to study interactions ...
Zheng Tan +3 more
wiley +1 more source
Metabolism in the tumor microenvironment: implications for pathogenesis and therapeutics. [PDF]
Front ImmunolWik JA +3 more
europepmc +1 more source
Microphysiological Systems of Lymphatics and Immune Organs
Advanced Healthcare Materials, EarlyView.This review surveys recent progress in engineering lymphatic microenvironments and immune organoids within microphysiological systems, emphasizing innovative strategies to recreate the biochemical and biophysical complexity of native lymphatic tissues.
Ishita Jain +2 more
wiley +1 more source
Nanosensitizer for enhanced radiotherapy via tumor microenvironment reshaping and ROS amplification. [PDF]
TheranosticsQian J +14 more
europepmc +1 more source
Bioengineered Lymphatic Vessels in Synthetic Matrices to Study Breast Cancer Cell Functions
Advanced Healthcare Materials, EarlyView.Lymphatic vessels are involved in cancer metastasis. To study the interplay between metastasizing cancer cells and lymphatic vessels under highly reproducible conditions, advanced in vitro models are required. In this work, 3D lymphatic networks are formed in biomimetic hydrogels and their interactions with invasive and non‐invasive cancer cell‐lines ...
Rodi Odabasi +7 more
wiley +1 more source
The application of nanotechnology in regulating mitochondrial function in tumor microenvironment for cancer therapy. [PDF]
TheranosticsWang D, Yuan M, Liu J, Zhao M, Fang T.
europepmc +1 more source
Synthetic Cell‐Based Tissues for Bottom‐Up Assembly of Artificial Lymphatic Organs
Advanced Healthcare Materials, EarlyView.Synthetic cells have emerged as a novel biomimetic approach for fundamental research and therapeutic interventions. T cell activating synthetic cells are able to form 3D tissue‐like structures by self‐assembly into lymphatic bottom‐up tissues (lymphBUT) with tunable biochemical and biomechanical functionalities as well as metabolic activity are ...
Anna Burgstaller +5 more
wiley +1 more source
Restoring the glioblastoma tumor microenvironment by targeting C5a with the antagonist W54011. [PDF]
Sci RepOh Y +9 more
europepmc +1 more source
Detection of neoantigen-specific T cells following a personalized vaccine in a patient with glioblastoma [PDF]
, 2019 Artyomov, Maxim N. +15 more
core +1 more source