Results 91 to 100 of about 648,894 (406)

Evidence of a role of tumor necrosis factor alpha in refractory asthma.

New England Journal of Medicine, 2006
BACKGROUND The development of tumor necrosis factor alpha (TNF-alpha) antagonists has made it feasible to investigate the role of this cytokine in refractory asthma.
M. Berry, B. Hargadon, M. Shelley, D. Parker, D. Shaw, R. Green, P. Bradding, C. Brightling, A. Wardlaw, I. Pavord   +9 more
semanticscholar   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Deep Model with Siamese Network for Viability and Necrosis Tumor Assessment in Osteosarcoma [PDF]

, 2019
Osteosarcoma is the most common primary malignant bone tumor, which has high mortality due to easy lung metastasis. Osteosarcoma is a highly anaplastic, pleomorphic tumor with a variety of tumor cell morphology, including fusiform, oval, epithelial, lymphocyte like, small round, transparent cells, etc.
arxiv   +1 more source

Pengaruh Larutan Kumur Ekstrak Etanol Tananman Sarang Semut (Myrmecodia Tuberose) Konsentrasi 10% Terhadap Penurunan Kadar Tumor Necrosis Factor-Alpha Pada Penderita Faringitis Akut [PDF]

, 2018
Pharyngitis is an inflammation on the pharyngeal wall. Pharyngitis can be caused by bacteria and viruses. Today many people are using herbs as health therapy.
-, drg. Sartari Entin Yuletnawati, MDSc, Margareta, Jeny Dwiki   +1 more
core  

FSH enhances the inflammatory response of macrophages in the knee joint possibly through the NFκB pathway

FEBS Open Bio, EarlyView.
We explored the role of FSH on the synovium and found that FSH was able to mediate the development of osteoarthritis by acting on the FSH receptor (FSHR) to promote the production and release of inflammatory factors through the activation of the NFκB signaling pathway. Previous studies have suggested that women with higher follicle‐stimulating hormone (
Yu Chen, Na Xu, Wen‐wen Zhang, Yan Wang, Tong Su, Yan‐man Zhou, Jin Xu   +6 more
wiley   +1 more source

Towards Machine Learning-based Quantitative Hyperspectral Image Guidance for Brain Tumor Resection [PDF]

arXiv, 2023
Complete resection of malignant gliomas is hampered by the difficulty in distinguishing tumor cells at the infiltration zone. Fluorescence guidance with 5-ALA assists in reaching this goal. Using hyperspectral imaging, previous work characterized five fluorophores' emission spectra in most human brain tumors.
arxiv  

Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha.

Journal of Clinical Investigation, 1994
Insulin resistance is an important metabolic abnormality often associated with infections, cancer, obesity, and especially non-insulin-dependent diabetes mellitus (NIDDM).
G. Hotamisligil, A. Budavari, David L. Murray, B. Spiegelman   +3 more
semanticscholar   +1 more source

Tumor necrosis factor-alpha and the cytokine network in psoriasis [PDF]

Anais Brasileiros de Dermatologia, 2012
New molecular methods of research have greatly expanded the knowledge about the role of cytokines in several diseases, including psoriasis. The work orchestrated by these peptides is essential for the communication between resident inflammatory cells (keratinocytes and endothelial cells) and infiltrating cells (neutrophils, lymphocytes, Langerhans ...
Cristiane Chaves Nascentes Machado, Arles Martins Brotas, Eduardo Henrique Jorge Lago, Jose Marcos T. Cunha, Sueli Carneiro, Sueli Carneiro   +5 more
openaire   +5 more sources

Tryptophan‐sensing receptor GPR142 expression levels are directly regulated by proinflammatory cytokines in ghrelin‐producing cells

FEBS Open Bio, EarlyView.
GPR142, a tryptophan‐sensing receptor, stimulates gastrointestinal hormones like ghrelin and is linked to inflammation regulation. Proinflammatory cytokines suppress ghrelin production, while tryptophan levels decrease via IDO1 activation. Our findings reveal that proinflammatory cytokines directly regulate GPR142 expression in ghrelin‐producing cells,
Yoko Ueda, Hiroshi Iwakura, Takuya Ensho, Mika Bando‐Shimizu, Asako Doi, Norihiko Matsutani, Shuhei Morita, Hidefumi Inaba, Hiroyuki Ariyasu, Naoki Fukuda, Keiji Hayata, Toshiyasu Ojima, Masahiro Nishi, Taka‐aki Matsuoka, Hiroki Yamaue, Takashi Akamizu   +15 more
wiley   +1 more source

Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist.

Proceedings of the National Academy of Sciences of the United States of America, 1993
Listeriosis in mice with the severe combined immunodeficiency (SCID) mutation is an established model in vivo and in vitro of interferon gamma (IFN-gamma)-dependent macrophage activation by natural killer (NK) cells during the development of natural ...
C. Tripp, S. Wolf, E. Unanue
semanticscholar   +1 more source