Results 201 to 210 of about 238,106 (335)

Isoquercitrin Alleviates Diabetic Nephropathy by Inhibiting STAT3 Phosphorylation and Dimerization

Advanced Science, EarlyView.
This study identified a natural compound, isoquercitrin, which significantly alleviated kidney inflammation and fibrosis by inhibiting STAT3 activity. Isoquercitrin forms a strong, noncovalent bond that directly binds to STAT3. Isoquercitrin binds to the pY+1 pocket of the SH2 domain of STAT3 via hydrogen bonding with Ser668, Gln635, and Gln633 ...
Chen Xuan, Donghui Chen, Shuangna Zhang, Chaofan Li, Qingyun Fang, Dinghua Chen, Jiabao Liu, Xin Jiang, Yingjie Zhang, Wanjun Shen, Guangyan Cai, Xiangmei Chen, Ping Li   +12 more
wiley   +1 more source

Transcriptional Activity of Tumor Necrosis Factor Alpha Genes and Their Receptors in Patients with Varying Degrees of Coronary Artery Disease. [PDF]

Int J Mol Sci
Potyka K, Dąbek J.
europepmc   +1 more source

Tumor necrosis factor alpha (TNF-alpha) production in mice immunized with Escherichia coli: correlation with mortality after lethal challenge and production of a native inhibitor of TNF-alpha activity [PDF]

, 1993
Giammarco Raponi, Nathan Keller, M. Rozenberg-Arska, Maria Teresa Lun, Carlo Mancini, J. Verhoef   +5 more
openalex   +1 more source

Gene sequence of porcine tumor necrosis factor alpha

Nucleic Acids Research, 1990
Roman T. Drews, Bradford W. Coffee, Annie K. Prestwood, R A McGraw   +3 more
openaire   +4 more sources

A Porphyrin Nanomaterial for Photoimmunotherapy for Treatment of Melanoma

Advanced Science, EarlyView.
The TPC@OVA NPs are developed as dual‐functional nanomaterials combining phototherapy and immunotherapy for melanoma treatment. This system effectively ablates primary tumors, induces immunogenic cell death, promotes dendritic cell maturation, and enhances T cell activation.
Zhuang Fan, Qing Pei, Haojie Sun, Haiyan Zhang, Zhigang Xie, Tao Zhang, Chong Ma   +6 more
wiley   +1 more source

Tumor Necrosis Factor-Alpha: Ally and Enemy in Protean Cutaneous Sceneries. [PDF]

Int J Mol Sci
Pocino K, Carnazzo V, Stefanile A, Basile V, Guerriero C, Marino M, Rigante D, Basile U.   +7 more
europepmc   +1 more source

Tumor necrosis factor alpha-induced phosphorylation of I kappa B alpha is a signal for its degradation but not dissociation from NF-kappa B.

, 1994
Shigeki Miyamoto, M. Maki, Mark J. Schmitt, Masashi Hatanaka, Inder M. Verma   +4 more
openalex   +1 more source

TRIM25‐Mediated INSIG1 Ubiquitination Promotes MASH Progression Through Reprogramming Lipid Metabolism

Advanced Science, EarlyView.
TRIM25‐mediated ubiquitination of INSIG1 serves as a key driver of lipid metabolism dysregulation in MASH progression. It identifies a novel small‐molecule inhibitor, C27H26N2O4S, which effectively inhibits TRIM25 activity, reducing lipid accumulation and inflammation.
Hao Zhang, Xiangxu Kong, Wei Wang, Huaxin Zhou, Haoran Qu, Zhengyao Guan, Honglei Wu, Xiangyu Zhai, Bin Jin   +8 more
wiley   +1 more source

Tumor necrosis factor-alpha inhibitors may increase the need for fine-needle aspiration cytology in axial spondyloarthritis patients. [PDF]

Rev Assoc Med Bras (1992)
Sayiner ZA, Munis HS, Köroğlu İ, Akyol EMB, Zengin O, Akarsu E.   +5 more
europepmc   +1 more source

Tumor Necrosis Factor-Alpha and Adiponectin in Nonalcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma. [PDF]

Cancers (Basel), 2023
Vachliotis ID, Valsamidis I, Polyzos SA.
europepmc   +1 more source