Results 221 to 230 of about 238,106 (335)

Histamine suppresses gene expression and synthesis of tumor necrosis factor alpha via histamine H2 receptors. [PDF]

, 1991
Edouard Vannier, Laurie C. Miller, C A Dinarello   +2 more
openalex   +1 more source

Reshape the Fates of Treg and CD8+T Cells Through IL‐2Rα by Synergizing Divergent Receptor‐Biased IL‐2 PEGylates

Advanced Science, EarlyView.
This study presents receptor‐biased IL‐2 PEGylates that selectively modulate IL‐2 receptor subunit interactions to enhance CD8⁺ T cell antitumor activity while curbing Treg activation and endothelial toxicity. The combined not‐α and not‐β variants balance immune stimulation and prevent T cell exhaustion, offering a novel, fine‐tuned approach for ...
Jiaqi Sun, Lingfeng Guo, Dezhong Ji, Mengfan Yu, Boyang Cheng, Xingxing Zhu, Yeshuang Yuan, Siyu Wu, Yuanjie Zhang, Wen Shi, Zhiqian Chen, Xindang Chu, Jiayu Hu, Liwen Hua, Yiming Wang, Yanning Zhu, Yu Mu, Hanwen Sun, Chuanling Zhang, Qi Wang, Sulong Xiao, Lihe Zhang, Bo Zhang, Demin Zhou   +23 more
wiley   +1 more source

Comparative Effects of Tumor Necrosis Factor Alpha, Lipopolysaccharide, and Palmitate on Mitochondrial Dysfunction in Cultured 3T3-L1 Adipocytes. [PDF]

Cell Biochem Biophys
Jack BU, Dias S, Pheiffer C.
europepmc   +1 more source

Tumor necrosis factor-alpha-dependent production of reactive nitrogen intermediates mediates IFN-gamma plus IL-2-induced murine macrophage tumoricidal activity. [PDF]

, 1992
George W. Cox, Giovanni Melillo, Utpala Chattopadhyay, D. Mullet, Richard H. Fertel, Luigi Varesio   +5 more
openalex   +1 more source

Semaphorin 3E–Plexin D1 Axis Drives Lung Fibrosis through ErbB2‐Mediated Fibroblast Activation

Advanced Science, EarlyView.
TGF‐β1 stimulation in fibroblasts leads to increased Furin expression, Furin‐mediated cleavage of P87‐Sema3E to P61‐Sema3E, which affects fibroblast function through the autocrine pathway, and the P61‐Sema3E‐PlexinD1 axis promotes fibroblast activation, proliferation and migration by affecting ErbB2 phosphorylation, which in turn activates the ErbB2 ...
Zhesong Deng, Jinkun Chen, Ruonan Yang, Yuan Zhan, Shanshan Chen, Jiaheng Zhang, Hao Fu, Yiya Gu, Qian Huang, Jixing Wu, Lianyu Shan, Abdelilah Soussi Gounni, Jungang Xie   +12 more
wiley   +1 more source

Correction: Antitumor effect of CAR-T cells targeting transmembrane tumor necrosis factor alpha combined with PD-1 mAb on breast cancers [PDF]

J Immunother Cancer
europepmc   +1 more source

Novel Pharmaceuticals and Therapeutics for Tumor Necrosis Factor-Alpha-Resistant Crohn's Disease: A Narrative Review. [PDF]

Cureus
Smith B, Smith H, Machini M.
europepmc   +1 more source

Tumor necrosis factor-alpha dependent cytotoxicity of human skin mast cells is enhanced by anti-IgE antibodies. [PDF]

, 1991
R. Christopher Benyon, Élyse Y. Bissonnette, A. Dean Befus   +2 more
openalex   +1 more source

Mitigating Doxorubicin‐Induced Cardiotoxicity and Enhancing Anti‐Tumor Efficacy with a Metformin‐Integrated Self‐Assembled Nanomedicine

Advanced Science, EarlyView.
A novel self‐assembled nanomedicine (PMDDH) has been developed for the co‐delivery of doxorubicin and metformin, aiming to enhance the anti‐tumor efficacy of doxorubicin while alleviating its cardiotoxicity through the activation of cGAS‐STING and AMPK signaling pathways, respectively.
Jiaxin Huang, Jieru Yang, Yuanying Yang, Xiaofeng Lu, Juan Xu, Shan Lu, Hong Pan, Wenhu Zhou, Wenqun Li, Songwen Chen   +9 more
wiley   +1 more source

Central nervous system effects of tumor necrosis factor alpha blockade

Journal of Translational Medicine, 2011
Schett Georg
doaj   +1 more source