Results 301 to 310 of about 506,829 (351)
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Tumor necrosis factor alpha disrupts tight junction assembly
Journal of Surgical Research, 2004We have previously shown an increase in intestinal permeability and a corresponding decrease in the expression of tight junction (TJ) proteins in the in testines of patients with Crohn's disease (CD). Tumor necrosis factor-alpha (TNFalpha) has been implicated in the inflammatory process of CD and its suppression has therapeutic benefit. ZO-1, occludin,
Lisa S, Poritz +3 more
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Tuberculosis Infections and Tumor Necrosis Factor Alpha Antagonists
American Journal of Therapeutics, 2013The treatment of rheumatologic diseases with tumor necrosis factor-alpha antagonists has become common practice. Studies have demonstrated an increased risk of active tuberculosis with use of tumor necrosis factor-alpha antagonists. We aim to better define the risk of tuberculosis infection associated with tumor necrosis factor-alpha antagonists and to
Justin, Gan +3 more
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Role of tumor necrosis factor alpha in asthma
Immunology and Allergy Clinics of North America, 2004Asthma is a heterogeneous disease in which various cytokines orchestrate airway inflammation. Tumor necrosis alpha (TNF-alpha) is a proinflammatory cytokine that has been implicated in the modulation of inflammation in various diseases, including asthma. Although TNF-alpha blocking strategies have been an effective therapeutic modality in diseases such
Babu, K. Suresh +2 more
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Priapism after tumor necrosis factor alpha inhibitor use
Clinical Rheumatology, 2015We present a possible important association of tumor necrosis factor-alpha inhibition (TNFa-i) and erectile function in a male patient with rheumatoid arthritis (RA). Long-standing, untreated RA may result in significant physical limitation and disability, however often overlooked is the association between RA and erectile and sexual dysfunction ...
Adam J, Kreitenberg +2 more
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Production of Tumor Necrosis Factor Alpha and Hemodialysis
Nephron, 1993The production of TNF alpha by peripheral blood mononuclear cells (PBMC) was determined in 18 hemodialysis (HD) patients. Blood was taken from each patient before and after an HD treatment. Both pre- and post-HD PBMC produced significantly more TNF alpha than controls (TNF alpha units/ml; mean +/- SEM; controls 3.1 +/- 0.7; pre-HD 9.7 +/- 3.9; post-HD ...
C, Macdonald +3 more
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[Tumor necrosis factor alpha. Biological aspects].
Giornale italiano di chemioterapia, 1989Human Tumor Necrosis Factor-alpha (TNF-alpha) is a multifaceted cytokine mainly produced by activated monocytes or macrophages. Several recent studies have shown that TNF-alpha can exert a variety of in vitro and in vivo effects including: modulation of normal and malignant haemopoiesis, antineoplastic activity, activation of neutrophils, induction of ...
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Cardiodepression by tumor necrosis factor-alpha.
European cytokine network, 1999Cardiodepressant effects of tumor necrosis factor-alpha (TNF-alpha have been documented in numerous experimental settings in vivo and in vitro. In vivo administration of TNF-alpha mimicks the cardiovascular pattern of sepsis including septic cardiomyopathy.
U, Müller-Werdan +2 more
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[Tumor necrosis factor-alpha (cachectin)].
Revista clinica espanola, 1989Tumor necrosis factor (TNF) is liberated by macrophages in response to infection. It has different biological effects, namely cytotoxicity on some tumor cell lines, anorexia, hyperlipidemia, and decreases in protein synthesis. It favors immunological responses and produces necrosis of certain tumors.
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Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance.
Science, 1993G. Hotamisligil +2 more
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Bioassay for Tumor Necrosis Factors-alpha and -beta
Molecular Biotechnology, 2000Tumor necrosis factor (TNF) is a central cytokine in the pathogenesis of septic shock and other inflammatory states. Assay by immunoassay is convenient, but, because of circulating soluble receptors, does not accurately reflect biological activity of the cytokine.
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