Results 301 to 310 of about 501,207 (351)
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[Tumor necrosis factor alpha].
Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1992TNF-alpha (Cachectin) is a cytokine (tissue hormone) synthesized and secreted as a trimeric polypeptide; major producers are the cells of the RES after stimulation, e.g. by endotoxin. Its synthesis is strictly regulated. TNF elicits a great number of cell-specific responses. IL-1 and probably additional mediators cooperate in these effects.
C S, Rock, S F, Lowry
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Serum Tumor Necrosis Factor-Alpha in Neonatal Sepsis
American Journal of Perinatology, 1997Tumor necrosis factor-alpha (TNF-alpha) is thought to be an important mediator in the pathogenesis of neonatal septicemia. To assess the role of TNF-alpha in neonatal sepsis, serum levels of TNF-alpha were measured in a group of neonates with septicemia and compared with the levels of gestational-postnatal, age-matched healthy controls.
Atici A. +3 more
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Bioassay for Tumor Necrosis Factors-alpha and -beta
Molecular Biotechnology, 2000Tumor necrosis factor (TNF) is a central cytokine in the pathogenesis of septic shock and other inflammatory states. Assay by immunoassay is convenient, but, because of circulating soluble receptors, does not accurately reflect biological activity of the cytokine.
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Immunology Letters, 1994
Eight murine anti-TNF alpha monoclonal antibodies (mAb) were produced after immunization of BALB/c mice with rhTNF alpha. Six of these mAbs were able to neutralize cytotoxic activity of TNF alpha against L929 cells. Two other mAbs had no neutralizing effect. Epitope mapping studies were performed by ELISA and by using a BIAcore system (Pharmacia).
B, Karim +3 more
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Eight murine anti-TNF alpha monoclonal antibodies (mAb) were produced after immunization of BALB/c mice with rhTNF alpha. Six of these mAbs were able to neutralize cytotoxic activity of TNF alpha against L929 cells. Two other mAbs had no neutralizing effect. Epitope mapping studies were performed by ELISA and by using a BIAcore system (Pharmacia).
B, Karim +3 more
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Role of lipopolysaccharide and tumor necrosis factor-alpha in induction of hepatocyte necrosis
American Journal of Physiology-Gastrointestinal and Liver Physiology, 1995The occurrence of acute hepatic failure during systemic inflammatory response syndrome (SIRS) is related to the extent of hepatocyte (HC) damage and cell death resulting from necrosis or apoptosis. We hypothesized that proinflammatory mediators such as lipopolysaccharide (LPS) and tumor necrosis factor-alpha (TNF-alpha) can, either directly or ...
J H, Wang +3 more
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The regulation of circadian clock by tumor necrosis factor alpha
Cytokine & Growth Factor Reviews, 2019All organisms display circadian rhythms which are under the control of the circadian clock located in the hypothalamus at the suprachiasmatic nucleus, (SCN). The circadian rhythms allow individuals to adjust their physiological activities and daily behavior for the diurnal changes in the living environment. To achieve these, all metabolic processes are
Mustafa Gokhan, Ertosun +2 more
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Tumor Necrosis Factor-Alpha Antagonist-Induced Sarcoidosis
JCR: Journal of Clinical Rheumatology, 2010Sarcoidosis is a multisystem granulomatous disease of unknown etiology. Tumor necrosis factor (TNF)-alpha is an important player in granuloma formation, and recent clinical trials have investigated the efficacy of TNF-alpha inhibitors in sarcoidosis. Paradoxically, there are several case reports in the medical literature describing the development of ...
Clementine, Rochelle Robicheaux +5 more
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Tuberculosis Infections and Tumor Necrosis Factor Alpha Antagonists
American Journal of Therapeutics, 2013The treatment of rheumatologic diseases with tumor necrosis factor-alpha antagonists has become common practice. Studies have demonstrated an increased risk of active tuberculosis with use of tumor necrosis factor-alpha antagonists. We aim to better define the risk of tuberculosis infection associated with tumor necrosis factor-alpha antagonists and to
Justin, Gan +3 more
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Sensors and Actuators B: Chemical, 2015
Abstract Tumor necrosis factor (TNF)-α promotes rheumatoid arthritis (RA) symptoms, including inflammation and bone erosion. The role of TNF-α in RA is considered to be complex because cytokine is responsible for a wide-range of functions, such as activation of immune cells, stimulation of osteoclast differentiation, and induction of cellular ...
Say, Rıdvan +4 more
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Abstract Tumor necrosis factor (TNF)-α promotes rheumatoid arthritis (RA) symptoms, including inflammation and bone erosion. The role of TNF-α in RA is considered to be complex because cytokine is responsible for a wide-range of functions, such as activation of immune cells, stimulation of osteoclast differentiation, and induction of cellular ...
Say, Rıdvan +4 more
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Cardiodepression by tumor necrosis factor-alpha.
European cytokine network, 1999Cardiodepressant effects of tumor necrosis factor-alpha (TNF-alpha have been documented in numerous experimental settings in vivo and in vitro. In vivo administration of TNF-alpha mimicks the cardiovascular pattern of sepsis including septic cardiomyopathy.
U, Müller-Werdan +2 more
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