Results 61 to 70 of about 6,121,735 (304)

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Curcumin Oral Gel and its Relation to Salivary Tumor Necrosis Factor-Alpha and Interleukin-6 that Treated Oral Mucositis in Head and Neck Cancer Patients Undergoing Concurrent Chemoradiation

Diyala Journal of Medicine
Background: Curcumin oral gel is one example of a traditional herbal medication, it has shown potential in several pharmaceutical uses. Oral mucositis is commonly prevent and treat using magic solution, a mouthwash that contains a combination of ...
Rouaa S. Farhan, Fawaz D. Al-Aswad
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Tumor Necrosis Factor Alpha: A Link between Neuroinflammation and Excitotoxicity

Mediators of Inflammation, 2014
Tumor necrosis factor alpha (TNF-α) is a proinflammatory cytokine that exerts both homeostatic and pathophysiological roles in the central nervous system.
Gabriel Olmos, Jerònia Lladó
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Release of TNF-α during myocardial reperfusion depends on oxidative stress and is prevented by mast cell stabilizers [PDF]

, 2003
Objectives: Our study sought to elucidate the role of oxidative stress for shedding of tumor necrosis factor-α (TNF-α) and for activating TNF-α-converting enzyme (TACE).
Welsch, Ulrich, Sommerhoff, Christian P., Gilles, Stefanie, Zahler, Stefan, Becker, Bernhard F.   +4 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Tumor necrosis factor alpha as a potential marker for prostate cancer

مجلة مركز بحوث التقنيات الاحيائية, 2020
Background: Prostate cancer is currently the most common cause of cancer death in men. The exact cause of developing prostate cancer is not known though inflammation, ageing, ethnicity and heredity are important factors involved in the initiation and ...
M. S. Ali, Salwa H. Al-Rubaei, Najwa S. Ahmed   +2 more
doaj   +1 more source

Tumor necrosis factor-alpha and the cytokine network in psoriasis [PDF]

Anais Brasileiros de Dermatologia, 2012
New molecular methods of research have greatly expanded the knowledge about the role of cytokines in several diseases, including psoriasis. The work orchestrated by these peptides is essential for the communication between resident inflammatory cells (keratinocytes and endothelial cells) and infiltrating cells (neutrophils, lymphocytes, Langerhans ...
Brotas, Arles Martins, Cunha, José Marcos Tellas, Lago, Eduardo Henrique Jorge, Machado, Cristiane Chaves Nascentes, Carneiro, Sueli Coelho da Silva   +4 more
openaire   +4 more sources