Results 61 to 70 of about 496,684 (306)

The relationships between eicosanoid production and pro-inflammatory cytokines [PDF]

, 2001
Explores alternate strategies that may alter inflammatory cytokine production, particularly tumour necrosis factor α [tumor necrosis factor-alpha], and therefore provide a possible treatment for rheumatoid arthritis.Thesis (Ph.D.) -- University of ...
Penglis, Peter Savas
core  

Confocal laser scanning microscope, raman microscopy and western blotting to evaluate inflammatory response after myocardial infarction [PDF]

, 2015
Cardiac muscle necrosis is associated with inflammatory cascade that clears the infarct from dead cells and matrix debris, and then replaces the damaged tissue with scar, through three overlapping phases: the inflammatory phase, the proliferative phase
Cantatore, S, De Carlo, D, Fineschi, Vittorio, Fiore, C, Neri, M, Riezzo, I, Turillazzi, E   +6 more
core   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Tumor Necrosis Factor Alpha: A Link between Neuroinflammation and Excitotoxicity

Mediators of Inflammation, 2014
Tumor necrosis factor alpha (TNF-α) is a proinflammatory cytokine that exerts both homeostatic and pathophysiological roles in the central nervous system.
Gabriel Olmos, Jerònia Lladó
doaj   +1 more source

TNFα induces Ca2+ influx to accelerate extrinsic apoptosis in hepatocellular carcinoma cells [PDF]

, 2018
BACKGROUND: Tumor necrosis factor-α has been proven an effective anticancer agent in preclinical studies. However, the translation of TNFα from research to clinic has been blocked by significant systemic toxicity and limited efficacy at maximal tolerated
Ji, Xiaoying, Jin, Mingpeng, Li, Deyang, Ren, Tingting, Wang, Jiaojiao, Wu, Yousheng, Xing, Jinliang, Yang, Hushan, Yin, Chun, Zhang, Hui, Zhu, Jianjun   +10 more
core   +4 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Psoriasiform Sarcoidosis Presenting in Pregnancy and Treatment Considerations [PDF]

, 2018
Cutaneous sarcoidosis is a common presentation for patients with sarcoidosis. Rarely, patients can present with psoriasiform lesions mimicking chronic plaque psoriasis. Here, we present a case of psoriasiform sarcoidosis in a pregnant patient.
Albornoz, Christian A., Keller, Matthew, Wang, Jordan   +2 more
core   +1 more source

Peroxynitrite is a potent inhibitor of NF-{kappa}B activation triggered by inflammatory stimuli in cardiac and endothelial cell lines. [PDF]

, 2005
Peroxynitrite is a potent oxidant and nitrating species proposed as a direct effector of myocardial damage in numerous cardiac pathologies. Whether peroxynitrite also acts indirectly, by modulating cell signal transduction in the myocardium, has not been
Feihl, F., Levrand, S., Liaudet, L., Pacher, P., Pesse, B., Rolli, J., Schaller, M.D., Waeber, B.   +7 more
core   +2 more sources

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Curcumin Oral Gel and its Relation to Salivary Tumor Necrosis Factor-Alpha and Interleukin-6 that Treated Oral Mucositis in Head and Neck Cancer Patients Undergoing Concurrent Chemoradiation

Diyala Journal of Medicine
Background: Curcumin oral gel is one example of a traditional herbal medication, it has shown potential in several pharmaceutical uses. Oral mucositis is commonly prevent and treat using magic solution, a mouthwash that contains a combination of ...
Rouaa S. Farhan, Fawaz D. Al-Aswad
doaj   +1 more source