Results 41 to 50 of about 314,005 (303)

Tumor Necrosis Factor-Alpha and Mast Cells: Revisited Study

European Journal of Inflammation, 2011
Mast cells reside in connective tissues and are widely recognized as effector cells important in innate and acquired immunity. These cells are the only ones capable of storing preformed TNFα in their cytoplasmatic granules and release upon activation ...
A. Saggini, D. Tripodi, G. Maccauro, M.L. Castellani, A. Anogeianaki, S. Teté, P. Felaco, M.A. De Luths, R. Galzio, M. Fulcheri, T.C. Theoharides, A. Caraffa, P. Antinolfi, M. Felaco, F. Conti, G. Neri, F. Pandolfi, E. Tomato, Y.B. Shaik-Dasthagirisaheb   +18 more
doaj   +1 more source

Hubungan antara Tumor Necrosis Factor Alpha dengan Demam Berdarah Dengue

Sari Pediatri, 2016
Latar belakang. Sampai saat ini patogenesis demam berdarah dengue (DBD) belum dipahami secara sempurna. Pada kasus DBD didapatkan adanya peningkatan kadar TNF-α, sitokin yang poten dalam meningkatkan permeabilitas pembuluh darah.
Felix Candra Sutanto, Max F.J. Mantik, Vivekenanda Pateda   +2 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Release of TNF-α during myocardial reperfusion depends on oxidative stress and is prevented by mast cell stabilizers [PDF]

, 2003
Objectives: Our study sought to elucidate the role of oxidative stress for shedding of tumor necrosis factor-α (TNF-α) and for activating TNF-α-converting enzyme (TACE).
Welsch, Ulrich, Sommerhoff, Christian P., Gilles, Stefanie, Zahler, Stefan, Becker, Bernhard F.   +4 more
core   +1 more source

Proinflammatory intervertebral disc cell and organ culture models induced by tumor necrosis factor alpha. [PDF]

, 2020
Inflammation plays an important role in the pathogenesis of intervertebral disc (IVD) degeneration. The proinflammatory cytokine tumor necrosis factor alpha (TNF-α) has shown markedly higher expression in degenerated human disc tissue compared with ...
Alini, Mauro, Gernot Lang, Li, Zhen, Lang, Gernot, Mauro Alini, Creemers, Laura B, Du, Jie, Pfannkuche, Judith-J, Häckel, Sonja, Sibylle Grad, Zhen Li, Grad, Sibylle, Laura B. Creemers, Jie Du, Pfannkuche, Judith-Johanna, Judith‐J. Pfannkuche, Sonja Häckel, Creemers, Laura B.   +17 more
core   +1 more source

Homer1a inhibits caspase-6 signaling to attenuate inflammatory pain in the spinal dorsal horn

Journal of International Medical Research
Objective This study aimed to investigate the effect of Homer1a on caspase-6/tumor necrosis factor-alpha signaling pathway in an inflammatory pain model.
Wenqian Zhao, Xiaoxiang Song, Minyi Yu, Kai Jiang   +3 more
doaj   +1 more source

Tumor necrosis factor alpha gene polymorphism in Serbian patients with sarcoidosis [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2013
Introduction. Sarcoidosis is a multisystemic disease of unknown etiology. Genetic factors play a considerable role in the onset of the disease. Tumor necrosis factor alpha (TNF-α) is a proinflammatory cytokine which plays an important role in the ...
Rađenović-Petković Tatjana, Pejčić Tatjana, Videnović-Ivanov Jelica, Jevtović-Stoimenov Tatjana, Janković Irena, Nastasijević-Borovac Desa, Radojković Danijela   +6 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source