Results 31 to 40 of about 6,121,735 (304)

Tumor necrosis factor alpha in sleep regulation

Sleep Medicine Reviews, 2018
This review details tumor necrosis factor alpha (TNF) biology and its role in sleep, and describes how TNF medications influence sleep/wake activity. Substantial evidence from healthy young animals indicates acute enhancement or inhibition of endogenous brain TNF respectively promotes and inhibits sleep.
Rockstrom, Matthew D, Chen, Liangyu, Taishi, Ping, Nguyen, Joseph T, Gibbons, Cody M, Veasey, Sigrid C, Krueger, James M   +6 more
openaire   +4 more sources

Single-cell multi-omics reveals the TNF-α activation threshold for Classical Monocytes by studying healthy donors and rheumatoid arthritis patients

Frontiers in Immunology
IntroductionTumor Necrosis Factor Alpha is a known pro-inflammatory cytokine that plays a key role in the pathogenesis of rheumatoid arthritis. Anti-cytokine therapies targeting Tumor Necrosis Factor Alpha have greatly succeeded in treating rheumatoid ...
Roman Perik-Zavodskii, Roman Perik-Zavodskii, Olga Perik-Zavodskaia, Saleh Alrhmoun, Saleh Alrhmoun, Julia Lopatnikova, Julia Lopatnikova, Alina Alshevskaya, Julia Zhukova, Julia Zhukova, Julia Shevchenko, Julia Shevchenko, Nadezhda Shkaruba, Natalia Sivitskaya, Shakir Suleimanov, Elizaveta Sheveleva, Kirill Nazarov, Fedor Kireev, Fedor Kireev, Alexey Sizikov, Elena Golikova, Sergey Sennikov, Sergey Sennikov   +22 more
doaj   +1 more source

Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease [PDF]

, 2011
We recently reported that expression levels of tumor necrosis factor (TNF) receptors, TNFR1 and TNFR2, are significantly changed in the brains and cerebral spinal cerebral fluid (CSF) with Alzheimer's disease (AD).
Blennow, Kaj,, Shen, Yong, Hampel, Harald, Rena Li, Hampel Harald, Prvulovic, David, Yong Shen, Wallin, Anders,, Jiang, Hong, David Prvulovic, Hong Jiang, Wallin, Anders, Kaj Blennow, Wallin Anders, Shen Yong, Anders Wallin, Li, Rena, Blennow Kaj, Jiang Hong, Prvulovic David, Harald Hampel, Blennow, Kaj, Li Rena   +22 more
core   +1 more source

Glaucomatous neurodegeneration: An eye on tumor necrosis factor-alpha

Indian Journal of Ophthalmology, 2012
Glaucoma, a neurodegenerative disease, is currently being treated by modulation of one of its primary risk factors, the elevated intraocular pressure. Newer therapies that can provide direct neuroprotection to retinal ganglion cells are being extensively
Renu Agarwal, Puneet Agarwal
doaj   +1 more source

Enhanced release of elastase is not concomitant with increased secretion of granulocyte-activating cytokines in whole blood from patients with sepsis [PDF]

, 1994
Die Diskussion am Ende des Artikels wurde gelöscht (§137l UrhG).Background The proteolytic enzyme elastase released by granulocytes (polymorphonuclear leukocytes [PMN]) in high concentrations during sepsis causes degradation of essential plasma proteins,
Schildberg, Friedrich-Wilhelm, Wolfgang Ertel, Jochum, Marianne, Thiele, Volker, Jarrar, Doreid, Kenney, John, Faist, Eugen, Ertel, Wolfgang   +7 more
core   +1 more source

Tumor Necrosis Factor Alpha in Amyotrophic Lateral Sclerosis: Friend or Foe?

Cells, 2021
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by a massive neuroinflammatory reaction, which plays a key role in the progression of the disease.
Giulia Guidotti, Chiara Scarlata, Liliana Brambilla, Daniela Rossi   +3 more
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Implications of a local overproduction of tumor necrosis factor-α in complex regional pain syndrome [PDF]

, 2011
Objective. To review the implications of a local overproduction of tumor necrosis factor-α for the pathogenesis and treatment of complex regional pain syndrome. Background.
Walker, S., Drummond, P.D.
core  

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Response to combination therapy with interferon alfa-2a and ribavirin in chronic hepatitis C according to a TNF-alpha promoter polymorphism [PDF]

, 2003
Background. Tumor necrosis factor-alpha (TNF-alpha) is involved in the pathogenesis of chronic active hepatitis C. Polymorphisms in the promoter region of the TNF-alpha gene can alter the TNF-alpha expression and modify the host immune response.
Konig, A., Folwaczny, Christian, Schmidt, F., Simperl, C., Schaefer, M., Torok, P., Glas, J., Schiemann, Uwe, Martin, K.   +8 more
core   +1 more source