Ischemic injury and liver graft congestion increase post-transplant interleukin-6 and tumor necrosis factor-alpha in hepatocellular carcinoma. [PDF]
Oh YJ, Choi GS, Kim J, Rhu J.
europepmc +1 more source
Tumor Necrosis Factor Receptor 2 Inhibits HIV-1 Infection by Blocking the Binding of gp120 to CD4. [PDF]
Gao Y +8 more
europepmc +1 more source
Tumor necrosis factor-alpha-mediated inflammatory bone loss: Pathogenic mechanisms and therapeutic potential of its inhibitors. [PDF]
Lin WY +8 more
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Glucocorticoid-Sparing Effect of Biologic Therapy in Rheumatoid Arthritis: A Single-Center Longitudinal Observational Study Comparing Rituximab With Tumor Necrosis Factor Inhibitors. [PDF]
Ben Marzouk I +7 more
europepmc +1 more source
Thyroid hormone changes after tumor necrosis factor inhibitor therapy in euthyroid patients with rheumatic diseases. [PDF]
Kizilkaya B +4 more
europepmc +1 more source
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Tumor necrosis factor is important in systemic and cutaneous defense, homeostasis, and many disease states. The numerous and diverse effects of tumor necrosis factor are best understood when considered as concentration-dependent, with normal homeostasis progressing to defense followed by toxic effects.
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Since the discovery of tumor necrosis factor (TNF) and lymphotoxin, many structurally related factors have been elucidated in mammals that are grouped together in the TNF Ligand Superfamily. These factors have profound pleiotropic roles involving inflammation, apoptosis, cell proliferation and stimulation of the immune system.
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Tumor Necrosis Factor and Anti-Tumor Necrosis Factor Therapies
The Journal of Rheumatology Supplement, 2010Tumor necrosis factor (TNF) plays a crucial role in the pathogenesis of immune-mediated inflammatory diseases (IMID). As a result, the inhibition of TNF is an important therapeutic avenue in the treatment of these pathophysiologically diverse disease states.
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