Results 91 to 100 of about 5,524,461 (249)

Tumor necrosis factor α Inhibition for Alzheimer’s Disease

Journal of Central Nervous System Disease, 2017
Tumor necrosis factor α (TNF-α) plays a central role in the pathophysiology of Alzheimer’s disease (AD). Food and Drug Administration–approved biologic TNF-α inhibitors are thus a potential treatment for AD, but they do not cross the blood-brain barrier.
Rudy Chang, Kei-Lwun Yee, Rachita K Sumbria   +2 more
doaj   +1 more source

Effect of Tumor Necrosis Factor on the Human Fibrinolytic System

, 1990
At the request of the authors, the following is a correction of reference 4 cited in the report "Effect of Tumor Necrosis Factor on the Human Fibrinolytic System" by Silverman et al (J Clin Oncol 8:468–475, 1990): Reference 4.
George H. Goldsmith, Thomas R. Spitzer, Paula Silverman, Esther H. Rehmus, Nathan A. Berger   +4 more
core   +1 more source

Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease [PDF]

, 2011
We recently reported that expression levels of tumor necrosis factor (TNF) receptors, TNFR1 and TNFR2, are significantly changed in the brains and cerebral spinal cerebral fluid (CSF) with Alzheimer's disease (AD).
Blennow, Kaj,, Shen, Yong, Hampel, Harald, Rena Li, Hampel Harald, Prvulovic, David, Yong Shen, Wallin, Anders,, Jiang, Hong, David Prvulovic, Hong Jiang, Wallin, Anders, Kaj Blennow, Wallin Anders, Shen Yong, Anders Wallin, Li, Rena, Blennow Kaj, Jiang Hong, Prvulovic David, Harald Hampel, Blennow, Kaj, Li Rena   +22 more
core   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Screening of the human tumor necrosis factor (TNF) gene and its receptor 1 (TNFR1) gene for DNA alterations and the subsequent investigation of these and an IL12p40 polymorphism for an association with paediatric tuberculosis [PDF]

, 2004
Includes bibliographical references (leaves 85-96).Infection with Mycobacterium tuberculosis is characterised by diverse outcomes; the majority of infected individuals remain well and yet others develop disease ranging from limited pulmonary tuberculosis
Lampel, Netanya
core   +1 more source

Single-cell multi-omics reveals the TNF-α activation threshold for Classical Monocytes by studying healthy donors and rheumatoid arthritis patients

Frontiers in Immunology
IntroductionTumor Necrosis Factor Alpha is a known pro-inflammatory cytokine that plays a key role in the pathogenesis of rheumatoid arthritis. Anti-cytokine therapies targeting Tumor Necrosis Factor Alpha have greatly succeeded in treating rheumatoid ...
Roman Perik-Zavodskii, Roman Perik-Zavodskii, Olga Perik-Zavodskaia, Saleh Alrhmoun, Saleh Alrhmoun, Julia Lopatnikova, Julia Lopatnikova, Alina Alshevskaya, Julia Zhukova, Julia Zhukova, Julia Shevchenko, Julia Shevchenko, Nadezhda Shkaruba, Natalia Sivitskaya, Shakir Suleimanov, Elizaveta Sheveleva, Kirill Nazarov, Fedor Kireev, Fedor Kireev, Alexey Sizikov, Elena Golikova, Sergey Sennikov, Sergey Sennikov   +22 more
doaj   +1 more source

Tumor necrosis factor inhibitors in tumor necrosis factor receptor-associated periodic syndrome: still a chance to work?

, 2017
The paper describes the opportunity of treating patients affected by TRAPS with tumor necrosis factor ...
Rigante, Donato
core   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Three cases of anti-TNF induced myositis and literature review

Revista Brasileira de Reumatologia
Anti-tumor necrosis factor drugs are frequently preferred in the treatment of rheumatologic diseases and other inflammatory diseases. The development of myositis after using anti-tumor necrosis factor drugs is a rare clinical condition.
Orhan Zengin, Mustafa Erkut Onder, Samet Alkan, Gezmiş Kimyon, Nergis Hüseynova, Zeynep Hanım Demir, Bünyamin Kısacık, Ahmet Mesut Onat   +7 more
doaj   +1 more source

Implication of Tumor Necrosis Factor - Alpha in Preeclampsia [PDF]

Applied Medical Informatics, 2008
Introduction: Preeclampsia is an exacerbation of a generalized inflammatory response, physiologically present in the third trimester of pregnancy.Aim: The aim of the study consists in the evaluation of proinflammatory cytokine TNF-α in the context of ...
Dan MIHU, Nicolae COSTIN, Ligia Daniela BLAGA, Septimiu CIUCHINĂ, Raluca Bogdana POP   +4 more
doaj