Results 261 to 270 of about 496,093 (307)

Serum Tumor Necrosis Factor-Alpha in Neonatal Sepsis

American Journal of Perinatology, 1997
Tumor necrosis factor-alpha (TNF-alpha) is thought to be an important mediator in the pathogenesis of neonatal septicemia. To assess the role of TNF-alpha in neonatal sepsis, serum levels of TNF-alpha were measured in a group of neonates with septicemia and compared with the levels of gestational-postnatal, age-matched healthy controls.
Atici A., Satar M., Çetíner S., Yaman A.   +3 more
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Tumor Necrosis Factor α and Toxicology

Critical Reviews in Toxicology, 1999
The molecular cloning of a group of proteins, collectively referred to as cytokines, and including interleukins, chemokines, growth factors, colony stimulating factors, and tumor necrosis factors, has allowed for the increased understanding of the mechanisms for many disease processes as well as provided strategies for the development of novel ...
M I, Luster, P P, Simeonova, R, Gallucci, J, Matheson   +3 more
openaire   +2 more sources

Nano anti-tumor necrosis factor-alpha based potentiometric sensor for tumor necrosis factor-alpha detection

Sensors and Actuators B: Chemical, 2015
Abstract Tumor necrosis factor (TNF)-α promotes rheumatoid arthritis (RA) symptoms, including inflammation and bone erosion. The role of TNF-α in RA is considered to be complex because cytokine is responsible for a wide-range of functions, such as activation of immune cells, stimulation of osteoclast differentiation, and induction of cellular ...
Say, Rıdvan, Özkütük, Ebru Birlik, Ünlüer, Özlem Biçen, Uğurag, Deniz, Ersöz, Arzu   +4 more
openaire   +2 more sources

Four epitopes on tumor necrosis factor-alpha defined by murine anti-tumor necrosis factor-alpha monoclonal antibodies

Immunology Letters, 1994
Eight murine anti-TNF alpha monoclonal antibodies (mAb) were produced after immunization of BALB/c mice with rhTNF alpha. Six of these mAbs were able to neutralize cytotoxic activity of TNF alpha against L929 cells. Two other mAbs had no neutralizing effect. Epitope mapping studies were performed by ELISA and by using a BIAcore system (Pharmacia).
B, Karim, R, Béliard, J J, Huart, D, Bourel   +3 more
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Tumor Necrosis Factor Alpha Production by Oral Leukocytes: Influence of Tumor Necrosis Factor Genotype

Journal of Periodontology, 1998
Tumor necrosis factor alpha (TNF‐α) is a proinflammatory cytokine that is thought to play a role in the pathogenesis of periodontal disease. TNF‐α production is regulated by many factors, including certain alleles of TNF gene polymorphisms. In the present study, TNF genotypes of 3 bi‐allelic polymorphisms were determined in 32 Caucasian patients with ...
G M, Galbraith, R B, Steed, J J, Sanders, J P, Pandey   +3 more
openaire   +2 more sources

Circulating bioactive tumor necrosis factor-α, tumor necrosis factor-α receptors, fibronectin, and tumor necrosis factor-α inducible cell adhesion molecule VCAM-1 in uncomplicated pregnancy

American Journal of Obstetrics and Gynecology, 1997
Our goal was to assess in a longitudinal study of uncomplicated pregnancy the course of maternal plasma concentrations of the bioactive cytokine tumor necrosis factor-alpha, the soluble tumor necrosis factor-alpha receptors sTNFRI and sTNFRII, the soluble cell adhesion molecule sVCAM-1, and circulating fibronectin.Blood was collected from 22 healthy ...
Beckmann, Ilse, Visser, Willy, Struijk, PC (Pieter), van Dooren, M, Glavimans, J, Wallenburg,   +5 more
openaire   +3 more sources

Tumor necrosis factor-α converting enzyme

The International Journal of Biochemistry & Cell Biology, 2002
Tumor necrosis factor-alpha converting enzyme (TACE/ADAM17/CD156q) is a member of the 'A Disintegrin And Metalloprotease', or ADAM, family. It is a multi-domain, type I transmembrane protein that includes an extracellular zinc-dependent protease domain.
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Tumor necrosis factor alpha disrupts tight junction assembly

Journal of Surgical Research, 2004
We have previously shown an increase in intestinal permeability and a corresponding decrease in the expression of tight junction (TJ) proteins in the in testines of patients with Crohn's disease (CD). Tumor necrosis factor-alpha (TNFalpha) has been implicated in the inflammatory process of CD and its suppression has therapeutic benefit. ZO-1, occludin,
Lisa S, Poritz, Kristian I, Garver, Anna F, Tilberg, Walter A, Koltun   +3 more
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Tuberculosis Infections and Tumor Necrosis Factor Alpha Antagonists

American Journal of Therapeutics, 2013
The treatment of rheumatologic diseases with tumor necrosis factor-alpha antagonists has become common practice. Studies have demonstrated an increased risk of active tuberculosis with use of tumor necrosis factor-alpha antagonists. We aim to better define the risk of tuberculosis infection associated with tumor necrosis factor-alpha antagonists and to
Justin, Gan, Augustine M, Manadan, Winston, Sequiera, Joel A, Block   +3 more
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Role of tumor necrosis factor alpha in asthma

Immunology and Allergy Clinics of North America, 2004
Asthma is a heterogeneous disease in which various cytokines orchestrate airway inflammation. Tumor necrosis alpha (TNF-alpha) is a proinflammatory cytokine that has been implicated in the modulation of inflammation in various diseases, including asthma. Although TNF-alpha blocking strategies have been an effective therapeutic modality in diseases such
Babu, K. Suresh, Davies, Donna E., Holgate, Stephen T.   +2 more
openaire   +3 more sources