Results 321 to 330 of about 666,626 (377)
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Tumor necrosis factor alpha in mycobacterial infection
Seminars in Immunology, 2014Tumor necrosis factor alpha (TNF-α) is a critical immune mediator in protection against and pathology of tuberculosis (TB). TNF-α had been found to be associated with TB when it was originally identified as cachexin and until today TB research continues to unveil novel roles of this cytokine of highest relevance for the disease process and for novel ...
Stefan H. E. Kaufmann, Anca Dorhoi
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Science, 1985
Modulation of the growth of human and murine cell lines in vitro by recombinant human tumor necrosis factor-alpha (rTNF-alpha) and recombinant human interferon-gamma (rIFN-gamma) was investigated.
B. Sugarman +5 more
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Modulation of the growth of human and murine cell lines in vitro by recombinant human tumor necrosis factor-alpha (rTNF-alpha) and recombinant human interferon-gamma (rIFN-gamma) was investigated.
B. Sugarman +5 more
semanticscholar +1 more source
Journal of Cellular Biochemistry, 2018
Pathogenesis of type 2 diabetes mellitus (T2DM) and development of insulin resistance are characterized by multi‐stimuli factors notably glucolipotoxicity, generation of reactive oxygen species (ROS), epigenetic factors, activation of various ...
M. Akash, K. Rehman, Aamira Liaqat
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Pathogenesis of type 2 diabetes mellitus (T2DM) and development of insulin resistance are characterized by multi‐stimuli factors notably glucolipotoxicity, generation of reactive oxygen species (ROS), epigenetic factors, activation of various ...
M. Akash, K. Rehman, Aamira Liaqat
semanticscholar +1 more source
American Journal of Respiratory and Critical Care Medicine, 1996
Asthma and chronic obstructive pulmonary disease are characterized by chronic airway inflammation. Studies using bronchoalveolar lavage (BAL) have shown an increased proportion of eosinophils in the BAL fluid from asthmatics compared with that from ...
V. Keatings +3 more
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Asthma and chronic obstructive pulmonary disease are characterized by chronic airway inflammation. Studies using bronchoalveolar lavage (BAL) have shown an increased proportion of eosinophils in the BAL fluid from asthmatics compared with that from ...
V. Keatings +3 more
semanticscholar +1 more source
Production of Tumor Necrosis Factor Alpha and Hemodialysis
Nephron, 1993The production of TNF alpha by peripheral blood mononuclear cells (PBMC) was determined in 18 hemodialysis (HD) patients. Blood was taken from each patient before and after an HD treatment. Both pre- and post-HD PBMC produced significantly more TNF alpha than controls (TNF alpha units/ml; mean +/- SEM; controls 3.1 +/- 0.7; pre-HD 9.7 +/- 3.9; post-HD ...
Rachel M. McKenna +3 more
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Serum Tumor Necrosis Factor-Alpha in Neonatal Sepsis
American Journal of Perinatology, 1997Tumor necrosis factor-alpha (TNF-alpha) is thought to be an important mediator in the pathogenesis of neonatal septicemia. To assess the role of TNF-alpha in neonatal sepsis, serum levels of TNF-alpha were measured in a group of neonates with septicemia and compared with the levels of gestational-postnatal, age-matched healthy controls.
Atici A. +3 more
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Sensors and Actuators B: Chemical, 2015
Abstract Tumor necrosis factor (TNF)-α promotes rheumatoid arthritis (RA) symptoms, including inflammation and bone erosion. The role of TNF-α in RA is considered to be complex because cytokine is responsible for a wide-range of functions, such as activation of immune cells, stimulation of osteoclast differentiation, and induction of cellular ...
Say, Rıdvan +4 more
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Abstract Tumor necrosis factor (TNF)-α promotes rheumatoid arthritis (RA) symptoms, including inflammation and bone erosion. The role of TNF-α in RA is considered to be complex because cytokine is responsible for a wide-range of functions, such as activation of immune cells, stimulation of osteoclast differentiation, and induction of cellular ...
Say, Rıdvan +4 more
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Immunology Letters, 1994
Eight murine anti-TNF alpha monoclonal antibodies (mAb) were produced after immunization of BALB/c mice with rhTNF alpha. Six of these mAbs were able to neutralize cytotoxic activity of TNF alpha against L929 cells. Two other mAbs had no neutralizing effect. Epitope mapping studies were performed by ELISA and by using a BIAcore system (Pharmacia).
Dominique Bourel +3 more
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Eight murine anti-TNF alpha monoclonal antibodies (mAb) were produced after immunization of BALB/c mice with rhTNF alpha. Six of these mAbs were able to neutralize cytotoxic activity of TNF alpha against L929 cells. Two other mAbs had no neutralizing effect. Epitope mapping studies were performed by ELISA and by using a BIAcore system (Pharmacia).
Dominique Bourel +3 more
openaire +3 more sources
Journal of Periodontology, 1998
Tumor necrosis factor alpha (TNF‐α) is a proinflammatory cytokine that is thought to play a role in the pathogenesis of periodontal disease. TNF‐α production is regulated by many factors, including certain alleles of TNF gene polymorphisms. In the present study, TNF genotypes of 3 bi‐allelic polymorphisms were determined in 32 Caucasian patients with ...
R. Britt Steed +3 more
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Tumor necrosis factor alpha (TNF‐α) is a proinflammatory cytokine that is thought to play a role in the pathogenesis of periodontal disease. TNF‐α production is regulated by many factors, including certain alleles of TNF gene polymorphisms. In the present study, TNF genotypes of 3 bi‐allelic polymorphisms were determined in 32 Caucasian patients with ...
R. Britt Steed +3 more
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Tumor Necrosis Factor-Alpha Antagonist-Induced Sarcoidosis
JCR: Journal of Clinical Rheumatology, 2010Sarcoidosis is a multisystem granulomatous disease of unknown etiology. Tumor necrosis factor (TNF)-alpha is an important player in granuloma formation, and recent clinical trials have investigated the efficacy of TNF-alpha inhibitors in sarcoidosis. Paradoxically, there are several case reports in the medical literature describing the development of ...
Clementine, Rochelle Robicheaux +5 more
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