Results 101 to 110 of about 34,617,262 (326)

Systematic Mutational Analysis of the Death Domain of the Tumor Necrosis Factor Receptor 1-associated Protein TRADD (*)

Journal of Biological Chemistry, 1996
Tumor necrosis factor receptor 1 (TNF-R1) mediates most of the biological properties of TNF including activation of the transcription factor NF-κB and programmed cell death.
Adam Park, V. Baichwal
semanticscholar   +1 more source

Identification and functional characterization of a mouse lymphotoxin beta-receptor like protein [PDF]

, 2005
Four different monoclonal rat anti mouse lymphotoxin beta-receptor (mLTbetaR) antibodies were generated in order to study the expression patterns and molecular mechanisms that follow the activation of this receptor which belongs to the TNFR superfamily ...
Seegers, Silvia
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

The effect of capsaicin on circulating biomarkers, soluble tumor necrosis factor and soluble tumor necrosis factor-receptor-1 and -2 levels in vivo using lipopolysaccharide-treated mice

Toxicology Reports, 2014
The circulating soluble tumor necrosis factor (sTNF) and sTNF-receptor (R) 1 and -R2 have known as septic biomarker. The pungent component of capsicum, capsaicin (Cap), has several associated physiological activities, including anti-oxidant, anti ...
Yoshio Ijiri, Ryuji Kato, Daisuke Sasaki, Fumio Amano, Kazuhiko Tanaka, Tetsuya Hayashi   +5 more
doaj   +1 more source

Flavonoid metabolites reduce tumor necrosis factor-α secretion to a greater extent than their precursor compounds in human THP-1 monocytes [PDF]

, 2015
This study was supported by funding from the UK Biotechnology and Biological Sciences Research Council Diet and Health Research Industry Club (BBSRC-DRINC) (BB/I006028/1) and by a studentship grant (BB/J500100/1).Scope: Flavonoids are generally studied ...
Kerr, J.S., Zhang, Q., O'Hagan, David, Kerr, Jason, Kay, C.D., Maria A. O'Connell, Sai Krishna Yalamanchili, Raheem, S., David O'Hagan, Colin D. Kay, O'Connell, M.A., O'Hagan, D., di Gesso, J.L., Kay, Colin, Jason S. Kerr, Saki Raheem, Zhang, Qingzhi, Krishna Yalamanchili, Sai, O’Hagan, D., Di Gesso, Jessica, O'Connell, Maria, Raheem, Saki, Yalamanchili, S.K., Jessica L. di Gesso, Qingzhi Zhang   +24 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Serum Cytokine Concentrations in a Patient with Rheumatoid Arthritis on Etanercept Therapy Who Subsequently Developed Pneumocystis Pneumonia: A Case Report

Case Reports in Rheumatology, 2011
We report a rheumatoid arthritis patient who was treated with etanercept. Serum levels of tumor-necrosis-factor- (TNF-) alpha, soluble-tumor-necrosis-factor receptor- (sTNFR-) I and -II, interleukin- (IL-) 6, and IL-1 beta were measured by ELISA before ...
Masao Sato, Masao Takemura, Ryuki Shinohe, Katsuji Shimizu   +3 more
doaj   +1 more source

Myosin II Light Chain Phosphorylation Regulates Membrane Localization and Apoptotic Signaling of Tumor Necrosis Factor Receptor-1*

Journal of Biological Chemistry, 2001
Activation of myosin II by myosin light chain kinase (MLCK) produces the force for many cellular processes including muscle contraction, mitosis, migration, and other cellular shape changes.
Yijun Jin, S. Atkinson, J. Marrs, P. Gallagher   +3 more
semanticscholar   +1 more source

Changes in expression of TNF alpha and its receptors mRNAs in oocytes and granulosa cells in mice with experimental immune ovarian failure [PDF]

, 2014
Purpose: To investigate the expression of TNF- α and its receptors (types I and II) at mRNA level in oocytes and granulose cells as well as to study effect of TNF-α on follicular cell death in mice with experimental immune ovarian failure induced by ...
Grushka, Nataliya, Dosenko, Victor, Shepel, Elena, Voznesenskaya, Tatyana, Yanchiy, Roman   +4 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source