Results 131 to 140 of about 2,022,996 (246)

Metabolic reprogramming of the immune response in periodontitis

Periodontology 2000, EarlyView.
Abstract Objective Periodontitis, a highly prevalent chronic inflammatory disease, is characterized by the progressive destruction of the tooth‐supporting tissues, ultimately causing tooth loss. In recent years, the emerging field of immunometabolism has revealed that immune cell function is tightly regulated by intracellular metabolic pathways that ...
Rafael Scaf de Molon, Melissa Grant, Iain Chapple, Joao Paulo Steffens   +3 more
wiley   +1 more source

MA11.11 Discrepancy of Tumor Neoantigen Burden Between Primary Lesions and Matched Metastases in Lung Cancer [PDF]

Journal of Thoracic Oncology, 2018
T. Jiang, C. Zhou
openaire   +1 more source

Supplementary Figure 2 from Tumor Burden Dictates the Neoantigen Features Required to Generate an Effective Cancer Vaccine

<p>Generation of CT26 #5KO and CT26 #23KO cells using CRISPR-Cas9 technology. A) CRISPR/Cas9 strategy used for the generation of CT26 cells lacking of nAg #5. Red arrows represent forward and reverse primers used for PCR. Blue lines 1 and 2 indicate 2 sgRNAs designed for Cas9-mediating genome editing, within exon 10, harboring #5 mutation (blue ...
Anna Morena D'Alise, Elisa Scarselli, Valeria Poli, Massimo Mallardo, Carmen Caiazza, Laura Conti, Giuseppina Romano, Simona Allocca, Gabriella Cotugno, Laura Antonucci, Laura Seclì, Guido Leoni, Fulvia Troise, Lidia Avalle, Linda Nocchi, Irene Garzia   +15 more
openaire   +1 more source

Spatial colocalization of neoantigen-expressing tumor cells and cognate T cells in cancer

Unique nucleotide sequences in somatic mutations and T cell receptors (TCR) provide molecular barcodes by which diverse tumor clones and T cells, respectively, can be distinguished.
Ghannam, Jack Y, Sud, Amit, Nagler, Adi
core  

Spatial colocalization of neoantigen-expressing tumor cells and cognate T cells in cancer 2309241

Introduction Tumor neoantigens have emerged as promising candidates for personalized immunotherapies, however, confirming their presentation and immunogenicity remains challenging due to low neoantigen expression and limited detection
Giovanni Marrero, Shuqiang Li, Vipin Kumar, Jack Ghannam, Alexander Afeyan, Fei Chen, Lucas Pomerance, Camila Robles-Oteiza, Andrew Russell, Nir Hacohen, Adi Nagler, Catherine Wu, McKayla Van-Orden, David Reardon, Charles Yoon, David Braun, Toni Choueiri, MacLean Sellars, Amit Sud, Qiyu Gong, Andrea Sonnenholzner, Patrick Ott, Wesley Lu, Jackson Weir, Kenneth Livak, Giacomo Oliveira   +25 more
core   +1 more source

Immunohistochemical Characterisation of Mismatch Repair Proteins in Feline Cancers: A Pilot Study Using Validated Cross‐Reactive Antibodies

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT DNA mismatch repair (MMR) deficiency is a clinically important biomarker in human oncology, yet its relevance in feline neoplasia remains poorly understood due to limited characterisation and the absence of validated reagents. In this study, we established a practical immunohistochemistry (IHC) approach for evaluating feline MMR proteins by ...
Shoma Nishibori, Masashi Sakurai, Yumiko Kagawa, Kazuo Nishigaki, Takayuki Nakagawa, Sakuya Inanaga, Masaya Igase, Takuya Mizuno   +7 more
wiley   +1 more source

Structural changes from wild-type define tumor-rejecting neoantigens

Journal for ImmunoTherapy of Cancer
Background Challenges in predicting which neoantigens mediate tumor rejection limit the efficacy of neoantigen vaccines to treat cancers, especially for cancers with a high mutational burden like cutaneous squamous cell carcinoma (cSCC).
Xing Li, Tao Ma, Anngela C Adams, Anne M Macy, Elizabeth S Borden, Lauren M Herrmann, Kenneth H Buetow, Melissa A Wilson, Denise J Roe, Karen Taraszka Hastings, Chad A Brambley, Sandip Ashok Sonar, Alysia Hughes, Aaron R Mangold, Janko Z Nikolich, Brian M Baker   +15 more
doaj   +1 more source

Hyperthermia‐induced cytotoxicity and modulation of PD‐L1 and MHC‐I expression in human non‐small cell lung cancer cell lines

Experimental Physiology, EarlyView.
Abstract Hyperthermia has recently been applied to treat human non‐small cell lung cancer (NSCLC). However, the mechanisms underlying cytotoxic sensitivity of NSCLC cells to hyperthermia are not fully understood. In this study, five NSCLC cell lines with different epidermal growth factor receptor (EGFR), Kirsten rat sarcoma and tumor protein p53 ...
Yun‐Chieh Tu, Wei‐Chen Yeh, Yi‐Wei Fang, Ko‐Hsuan Lo, Lei‐Ni Liang, Xu‐Chen Liu, Chia‐Chi Tsai, Chih‐Cheng Cheng, Meng‐Chieh Lin, Hsin‐Hsien Yu, Bor‐Chyuan Su   +10 more
wiley   +1 more source

Supplementary Table 2 from SpliceMutr Enables Pan-Cancer Analysis of Splicing-Derived Neoantigen Burden in Tumors

<p>Supplementary Table S2. Splicing antigenicity differences between samples with mutated and samples without mutated splicing factor genes. The splicing antigenicity differences between samples with mutated and non-mutated splicing factors for all 119 chosen splicing factor genes and for each TCGA cancer subtype.</p>
Ludmila Danilova, Elana J. Fertig, Daria A. Gaykalova, Rachel Karchin, Valsamo Anagnostou, Alexander V. Favorov, Elizabeth M. Jaffee, Nilofer S. Azad, Jessica Gore, Ali M. Saeed, Tamara Y. Lopez-Vidal, Neeha Zaidi, Mark Yarchoan, Archana Balan, Xiaoshan M. Shao, Michael D. Kessler, Theron Palmer   +16 more
openaire   +1 more source

Nontumor‐Specific mRNA Sensitization of Cold Tumors to Immune Checkpoint Blockade: Evidence, Bias, and Requirements for Translation

Advanced Oncology, Volume 1, Issue 1, December 2026.
Messenger RNA constructs encoding nontumor antigens are proposed to sensitize cold tumors to checkpoint blockade. Observational survival estimates favor vaccination but are heterogeneous, and bias‐focused analyses find no significant difference once time‐zero is aligned. Epitope spreading remains undemonstrated in humans. This review separates what the
Sarfaraz K. Niazi
wiley   +1 more source