Results 161 to 170 of about 2,022,996 (246)

Investigating possible approval paths of individualized neoantigen based therapeutic vaccines from a regulatory perspective

, 2020
Introduction: Mortality in cancer has declined during recent years due to more efficient cancer treatments. Some of the novel immunotherapies against cancer under development has a risk of lacking regulatory guidance for the approval, such as neoantigen ...
Eng, Layla
core  

Durable Complete Response to Pembrolizumab for Postoperative Nodal Recurrence of Lynch Syndrome–Associated Upper Tract Urothelial Carcinoma: A Case Report

IJU Case Reports, Volume 9, Issue 6, November 2026.
ABSTRACT Introduction Germline mutations in mismatch repair genes cause Lynch syndrome and are associated with upper tract urothelial carcinoma (UTUC). Tumors with deficient mismatch repair (dMMR) or microsatellite instability–high (MSI‐H) may respond favorably to immune checkpoint inhibitors.
Kaya Atagi, Shinkuro Yamamoto, Nobutaka Shimizu, Mitsuko Iguchi, Ryu Shigehisa, Tomoya Nao, Tsutomu Shimamoto, Hideo Fukuhara, Satoshi Fukata, Keiji Inoue   +9 more
wiley   +1 more source

The FOXQ1/SSBP2 Regulatory Axis Drives Malignant Progression of Melanoma

Molecular Carcinogenesis, Volume 65, Issue 11, Page 1459-1477, November 2026.
ABSTRACT Melanoma is a highly aggressive skin cancer with poor prognosis, often linked to excessive UV exposure. Despite advancements in immunotherapy and targeted treatments, melanoma's invasiveness and metastatic potential remain significant challenges.
Xiaoyu Zhang, Yu Hou, Jiahui Liu, Yuehua Han, Jiangang Feng   +4 more
wiley   +1 more source

Sulfonium‐Stapled Peptides‐Based Neoantigen Delivery System for Personalized Tumor Immunotherapy and Prevention

Neoantigen peptides hold great potential as vaccine candidates for tumor immunotherapy. However, due to the limitation of antigen cellular uptake and cross‐presentation, the progress with neoantigen peptide‐based vaccines has obviously lagged in clinical
Jianbo Liu, Yaping Zhang, Siyong Huang, Huiting Liang, Fei Lu, Feng Yin, Rui Wang, Yuhao An, Zigang Li, Chenshan Lian, Xiaojing Tian, Youdong Pan, Yun Xing, Leying Jiang, Wei Han, Zhihong Liu   +15 more
core   +1 more source

Bispecific NK‐Cell Engager Targeting TP53 Mutation Through Integration of a TCR‐mimic Antibody

MedComm, Volume 7, Issue 11, November 2026.
Most existing NK cell engagers (NKCEs) target tumor‐associated antigens (TAAs), risking on‐target, off‐tumor toxicity. We engineered a novel NKCE termed C33×CD16, a single‐chain diabody (scDb) constructed by fusing TCR‐mimic antibody C33‐Ab (targeting p53R175H/HLA‐A*02:01) to the scFv of 3G8 (anti‐CD16 antibody) (a).
Hanfei Wu, Zhe Zhao, Li Zhang, Xuan Xiong, Mengdie Yang, Weiping Ge, Danyue Zhi, Xiaobin Cao, Chuanqian Yi, Yong Qiao, Junjun Cao, Yan Mei, Shiping Jiao, Quan Liu, Hao Zhou, Zhongjuan Xu, Guangli Suo   +16 more
wiley   +1 more source

Atherosclerosis: From Pathogenesis to Therapeutic Interventions

MedComm, Volume 7, Issue 11, November 2026.
The diagram outlines the core mechanisms driving atherosclerosis, including endothelial dysfunction, inflammatory responses, phenotypic switching of smooth muscle cells, and the gut–vascular axis. It also presents the corresponding therapeutic approaches now under development, such as gene therapies, immunotherapies, and nanotechnology platforms ...
Enge Zhou, Chenxi Zhan, Yuting Li, Yi Zeng, Renfei Luo, Xin Ouyang, Shixing Liu, Renqiang Yang, Nianlong Yan, Long Jiang   +9 more
wiley   +1 more source

Dedifferentiation in endometrial cancer is associated with HLA‐I silencing that may be restored by IFN‐γ

The Journal of Pathology, Volume 270, Issue 3, Page 317-327, November 2026.
Abstract Dedifferentiated endometrial carcinoma occurs when a prognostically favorable low‐grade endometrial carcinoma transforms into a highly aggressive undifferentiated carcinoma following genomic inactivation of core SWItch/Sucrose Non‐Fermentable (SWI/SNF) complex protein(s).
Antonio De Leo, Madison Wickenberg, Marco Grillini, Camelia Alexandra Coadǎ, Pooja Praveen Kumar, Annie Tong, James Key, Hannah Kim, Felix Kommoss, Mark Carey, Yangxin Fu, Claudio Ceccarelli, Giovanni Tallini, Paul LaPointe, Martin Köbel, Cheng‐Han Lee   +15 more
wiley   +1 more source

Personalized mRNA Neoantigen Vaccines in Cancer: Linking Precision Antigen Selection, Immune Remodeling, and Checkpoint Blockade. [PDF]

Int J Mol Sci
Demircan T, Yıldırım B, Ünsal Hİ, Bilir A.   +3 more
europepmc   +1 more source

Integrating Machine Learning to Identify Prognostic Subtypes and the Cisplatin Resistance Gene RRM2 in Lung Adenocarcinoma

Thoracic Cancer, Volume 17, Issue 21, November 2026.
Integrative multi‐omics clustering identified two molecular subtypes of lung adenocarcinoma (LUAD), and a 19‐gene consensus machine learning‐derived signature (CMLS) stratified patients by prognosis and immunotherapy response. Low‐CMLS tumors showed favorable survival, enhanced CD4 + T‐cell infiltration, higher TMB/TNB, and an immune‐hot phenotype ...
Huirong Huang, Ting Tao, Zhenqing Li, Kerong Zhai, Baiqiang Cui, Haiming Feng, Peiqiang Li, Bin Li   +7 more
wiley   +1 more source

Induced mismatch repair deficiency: a hypothesis for the transient and reversible sensitization of mismatch repair-proficient tumors to Immune checkpoint blockade. [PDF]

Front Immunol
Assumpção PP, Leal A, Barra WF, Hirata MH, Steimbach JV, Burbano RMR, Kassab P, Bencivenga M, Bonamino MH, P&D consortium.   +9 more
europepmc   +1 more source