Results 61 to 70 of about 5,576,002 (348)

Cellular senescence and SASP in tumor progression and therapeutic opportunities

Molecular Cancer
Cellular senescence (CS), a permanent and irreversible arrest of the cell cycle and proliferation leading to the degeneration of cellular structure and function, has been implicated in various key physiological and pathological processes, particularly in
Zening Dong, Yahan Luo, Zhangchen Yuan, Yu Tian, Tianqiang Jin, Feng Xu   +5 more
semanticscholar   +1 more source

circNDUFB2 inhibits non-small cell lung cancer progression via destabilizing IGF2BPs and activating anti-tumor immunity

Nature Communications, 2021
Circular RNAs (circRNA) are a class of covalently closed single-stranded RNAs that have been implicated in cancer progression. Here we identify circNDUFB2 to be downregulated in non-small cell lung cancer (NSCLC) tissues, and to negatively correlate with
Botai Li, Li-Li Zhu, Chunlai Lu, Cun Wang, Hui Wang, Haojie Jin, Xuhui Ma, ZhuoAn Cheng, Chengtao Yu, Siying Wang, Q. Zuo, Yangyang Zhou, Jun Wang, Chen Yang, Yuanyuan Lv, Liyan Jiang, Wenxin Qin   +16 more
semanticscholar   +1 more source

mLST8 Promotes mTOR-Mediated Tumor Progression. [PDF]

PLoS ONE, 2015
The activity of the mechanistic target of rapamycin (mTOR) is elevated in various types of human cancers, implicating a role in tumor progression. However, the molecular mechanisms underlying mTOR upregulation remain unclear. In this study, we found that
Kyoko Kakumoto, Jun-Ichiro Ikeda, Masato Okada, Eiichi Morii, Chitose Oneyama   +4 more
doaj   +1 more source

Targeting ROCK activity to disrupt and prime pancreatic cancer for chemotherapy [PDF]

, 2017
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease; the identification of novel targets and development of effective treatment strategies are urgently needed to improve patient outcomes.
Olson, Michael F., Pajic, Marina, Rath, Nicola, Timpson, Paul, Vennin, Claire   +4 more
core   +1 more source

Microsatellite instability and mismatch repair deficiency in bladder urothelial carcinoma: a Tunisian single-center study

Journal of the Egyptian National Cancer Institute
Background Microsatellite instability (MSI) and deficiency in the human mismatch repair (MMR) system are critical drivers of genomic instability in various cancers.
Ahlem Bdioui, Mariem Akkari, Maroua Krifa, Yosra Souiden, Ethmane Sleimane, Wafa Mokni, Nada Ben Lazrek, Sarra Mestiri, Sihem Hmissa, Nabiha Missaoui   +9 more
doaj   +1 more source

Microvesicles and chemokines in tumor microenvironment: mediators of intercellular communications in tumor progression

Molecular Cancer, 2019
Increasing evidence indicates that the ability of cancer cells to convey biological information to recipient cells within the tumor microenvironment (TME) is crucial for tumor progression.
Xiaojie Bian, Yu-Tian Xiao, Tianqi Wu, Mengfei Yao, Leilei Du, Shancheng Ren, Jianhua Wang   +6 more
doaj   +1 more source

CXCL8 in Tumor Biology and Its Implications for Clinical Translation

Frontiers in Molecular Biosciences, 2022
The chemokine CXCL8 has been found to play an important role in tumor progression in recent years. CXCL8 activates multiple intracellular signaling pathways by binding to its receptors (CXCR1/2), and plays dual pro-tumorigenic roles in the tumor ...
Xingyu Xiong, Xinyang Liao, Shi Qiu, Shi Qiu, Hang Xu, Shiyu Zhang, Sheng Wang, Jianzhong Ai, Lu Yang   +8 more
doaj   +1 more source

Escape from immunotherapy: possible mechanisms that influence tumor regression/progression [PDF]

, 2004
Tumor escape is one major obstacle that has to be addressed prior to designing and delivering successful immunotherapy. There is compelling evidence to support the notion that immunogenic tumors, in murine models and cancer patients, can be rejected by ...
Ahmad, M, Ali, SA, Rees, RC
core   +1 more source

Pazopanib Combined With Vincristine and Irinotecan in Relapsed Wilms Tumor: Encouraging Outcomes in a Heavily Pretreated Pediatric Cohort

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background While Wilms tumor (WT) typically has a favorable prognosis, relapsed cases—especially those with high‐risk histology—remain therapeutically challenging after intensive frontline therapy. The combination of vincristine and irinotecan has demonstrated activity in pediatric solid tumors, and pazopanib, a multi‐targeted tyrosine kinase ...
Maria Debora De Pasquale, Alessandro Crocoli, Giuseppe Maria Milano, Pierluigi Di Paolo, Francesca Diomedi Camassei, Ida Russo, Annalisa Serra   +6 more
wiley   +1 more source

Regulation of pancreatic cancer aggressiveness by stromal stiffening [PDF]

, 2016
No abstract ...
A Neesse, AD Rhim, BC Özdemir, H Laklai, I Barbieri, JJ Lee, JK Mouw, JM Bailey, Michael F Olson, Nicola Rath, P Bailey, SR Hingorani, SR Hingorani, V Sanz-Moreno   +13 more
core   +1 more source