Results 41 to 50 of about 359,694 (255)

Genomic characterization of the human mitochondrial tumor suppressor gene 1 (MTUS1): 5' cloning and preliminary analysis of the multiple gene promoters

BMC Research Notes, 2009
Background Mitochondrial tumor suppressor gene 1 (MTUS1) has been recently identified as a candidate tumor suppressor gene which resides in a genomic region (8p22) that shows frequent loss of heterozygosity (LOH) in several tumor types.
Ye Hui, Liu Xiqiang, Yu Jinsheng, Zhou Xiaofeng   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

p53 in renal cell carcinoma: a biomarker for disease progression

مجلة كلية الطب, 2011
Background: P53 is an important tumor marker in many malignancies, the P53 gene is a tumor suppressor gene that plays a key role in the regulation of the cell cycle.
Manal A. Habib, Mazin J. Ibrahim, Saad D. Farhan   +2 more
doaj   +1 more source

Comparison of the fertility of tumor suppressor gene-deficient C57BL/6 mouse strains reveals stable reproductive aging and novel pleiotropic gene

Scientific Reports, 2021
Tumor suppressor genes are involved in maintaining genome integrity during reproduction (e.g., meiosis). Thus, deleterious alleles in tumor suppressor-deficient mice would exhibit higher mortality during the perinatal period.
Masaoki Kohzaki, Akira Ootsuyama, Toshiyuki Umata, Ryuji Okazaki   +3 more
doaj   +1 more source

Tumor suppressor genes in the tumor microenvironment

Disease Models & Mechanisms
ABSTRACT Tumor suppressor genes (TSGs) are thought to suppress tumor development primarily via cancer cell-autonomous mechanisms. However, the tumor microenvironment (TME) also significantly influences tumorigenesis. In this context, a role for TSGs in the various cell types of the TME in regulating tumor growth is emerging.
Bahareh Tabanifar, Hannah Lau, Kanaga Sabapathy   +2 more
openaire   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Retinoblastoma tumor suppressor gene: An overview

Journal of Indian Academy of Oral Medicine and Radiology, 2012
A genetic basis for the development of cancer has been hypothesized for nearly a century and has been supported by familial, epidemiological and cytogenetic studies.
Sunila Thomas, Anita Balan
doaj  

p53 target ANKRA2 cooperates with RFX7 to regulate tumor suppressor genes

Cell Death Discovery
The transcription factor regulatory factor X 7 (RFX7) has been identified as a tumor suppressor that is recurrently mutated in lymphoid cancers and appears to be dysregulated in many other cancers. RFX7 is activated by the well-known tumor suppressor p53
Katjana Schwab, Konstantin Riege, Luis Coronel, Clara Stanko, Silke Förste, Steve Hoffmann, Martin Fischer   +6 more
doaj   +1 more source

Disentangling PTEN-cooperating tumor suppressor gene networks in cancer

Molecular & Cellular Oncology, 2017
We have recently performed a whole-body, genome-wide screen in mice using a single-copy inactivating transposon for the identification of Pten (phosphatase and tensin homolog)-cooperating tumor suppressor genes (TSGs).
Jorge de la Rosa, Julia Weber, Roland Rad, Allan Bradley, Juan Cadiñanos   +4 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source