Results 41 to 50 of about 370,667 (257)

Retinoblastoma tumor suppressor gene: An overview

Journal of Indian Academy of Oral Medicine and Radiology, 2012
A genetic basis for the development of cancer has been hypothesized for nearly a century and has been supported by familial, epidemiological and cytogenetic studies.
Sunila Thomas, Anita Balan
doaj  

p53 target ANKRA2 cooperates with RFX7 to regulate tumor suppressor genes

Cell Death Discovery
The transcription factor regulatory factor X 7 (RFX7) has been identified as a tumor suppressor that is recurrently mutated in lymphoid cancers and appears to be dysregulated in many other cancers. RFX7 is activated by the well-known tumor suppressor p53
Katjana Schwab, Konstantin Riege, Luis Coronel, Clara Stanko, Silke Förste, Steve Hoffmann, Martin Fischer   +6 more
doaj   +1 more source

Genomic characterization of the human mitochondrial tumor suppressor gene 1 (MTUS1): 5' cloning and preliminary analysis of the multiple gene promoters

BMC Research Notes, 2009
Background Mitochondrial tumor suppressor gene 1 (MTUS1) has been recently identified as a candidate tumor suppressor gene which resides in a genomic region (8p22) that shows frequent loss of heterozygosity (LOH) in several tumor types.
Ye Hui, Liu Xiqiang, Yu Jinsheng, Zhou Xiaofeng   +3 more
doaj   +1 more source

Comparison of the fertility of tumor suppressor gene-deficient C57BL/6 mouse strains reveals stable reproductive aging and novel pleiotropic gene

Scientific Reports, 2021
Tumor suppressor genes are involved in maintaining genome integrity during reproduction (e.g., meiosis). Thus, deleterious alleles in tumor suppressor-deficient mice would exhibit higher mortality during the perinatal period.
Masaoki Kohzaki, Akira Ootsuyama, Toshiyuki Umata, Ryuji Okazaki   +3 more
doaj   +1 more source

Against the Resilience of High-Grade Gliomas: Gene Therapies (Part II)

Brain Sciences, 2021
Introduction: High-grade gliomas (HGGs) still have a high rate of recurrence and lethality. Gene therapies were projected to overcome the therapeutic resilience of HGGs, due to the intrinsic genetic heterogenicity and immune evasion pathways. The present
Alice Giotta Lucifero, Sabino Luzzi
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Atonal homolog 1 is a tumor suppressor gene.

PLoS Biology, 2009
Colon cancer accounts for more than 10% of all cancer deaths annually. Our genetic evidence from Drosophila and previous in vitro studies of mammalian Atonal homolog 1 (Atoh1, also called Math1 or Hath1) suggest an anti-oncogenic function for the Atonal ...
Wouter Bossuyt, Avedis Kazanjian, Natalie De Geest, Sofie Van Kelst, Gert De Hertogh, Karel Geboes, Greg P Boivin, Judith Luciani, Francois Fuks, Marinee Chuah, Thierry VandenDriessche, Peter Marynen, Jan Cools, Noah F Shroyer, Bassem A Hassan   +14 more
doaj   +1 more source

p53 in renal cell carcinoma: a biomarker for disease progression

مجلة كلية الطب, 2011
Background: P53 is an important tumor marker in many malignancies, the P53 gene is a tumor suppressor gene that plays a key role in the regulation of the cell cycle.
Manal A. Habib, Mazin J. Ibrahim, Saad D. Farhan   +2 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Tumor suppressor genotype influences the extent and mode of immunosurveillance in lung cancer

Nature Communications
The impact of cancer driving mutations on immunosurveillance throughout tumor development remains poorly understood. To better understand the contribution of tumor genotype to immunosurveillance, we generated and validated lentiviral-based vectors that ...
Keren M. Adler, Haiqing Xu, Amy C. Gladstein, Valerie M. Irizarry-Negron, Maggie R. Robertson, Katherine R. Doerig, Dmitri A. Petrov, Monte M. Winslow, David M. Feldser   +8 more
doaj   +1 more source