Results 31 to 40 of about 539,541 (293)
NTRK3 is a potential tumor suppressor gene commonly inactivated by epigenetic mechanisms in colorectal cancer. [PDF]
PLoS Genetics, 2013 NTRK3 is a member of the neurotrophin receptor family and regulates cell survival. It appears to be a dependence receptor, and thus has the potential to act as an oncogene or as a tumor suppressor gene. NTRK3 is a receptor for NT-3 and when bound to NT-3
Yanxin Luo +8 more
doaj +1 more source
Synthetic lethal approaches to target cancers with loss of PTEN function
Genes and Diseases, 2023 Phosphatase and tensin homolog (PTEN) is a tumor suppressor gene and has a role in inhibiting the oncogenic AKT signaling pathway by dephosphorylating phosphatidylinositol 3,4,5-triphosphate (PIP3) into phosphatidylinositol 4,5-bisphosphate (PIP2).
Ayse Ertay, Rob M. Ewing, Yihua Wang
doaj +1 more source
Dose-Response, 2013 A novel first-generation st ochastic gene ep isilencing ( STEP1 ) model is introduced for quantitatively characterizing the probability of in vitro epigenetically silencing (episilencing) specific tumor-suppressor- microRNA (miRNA ) genes by carcinogen ...
Bobby R. Scott
doaj +1 more source
Neoplasia: An International Journal for Oncology Research, 2001 Recently, loss of heterozygosity (LOH) studies suggest that more than two tumor suppressor genes lie on the short arm of chromosome 1 (1p) in neuroblastoma (NB).
Hong Wei Yang +5 more
doaj +1 more source
miRNAs link metabolic reprogramming to oncogenesis [PDF]
, 2013 The most profound biochemical phenotype of cancer cells is their ability to metabolize glucose to lactate, even under aerobic conditions. This alternative metabolic circuitry is sufficient to support the biosynthetic and energy requirements for cancer ...
Hatziapostolou, M +2 more
core +1 more source
Correlation of primary tumor size and axillary nodal status with tumor suppressor gene p53 in breast carcinoma [PDF]
Vojnosanitetski Pregled, 2002 Correlation of standard path morphological prognostic parameters, primary tumor size and axillary nodal status with new prognostic factor in breast carcinoma: tumor suppressor gene p53 was analyzed.
Topić Brano +3 more
doaj +1 more source
Is Lactate an Oncometabolite? Evidence Supporting a Role for Lactate in the Regulation of Transcriptional Activity of Cancer-Related Genes in MCF7 Breast Cancer Cells. [PDF]
, 2019 Lactate is a ubiquitous molecule in cancer. In this exploratory study, our aim was to test the hypothesis that lactate could function as an oncometabolite by evaluating whether lactate exposure modifies the expression of oncogenes, or genes encoding ...
Brooks, George A +4 more
core +1 more source
PIK3CA is recurrently mutated in canine mammary tumors, similarly to in human mammary neoplasia
Scientific Reports, 2023 Biological features of neoplastic disease affecting mammary gland tissue are shared between canines and humans. Research performed in either species has translational value and early phase clinical trials performed in canines with spontaneous disease ...
Maja Louise Arendt +9 more
doaj +1 more source
The human ARF tumor suppressor senses blastema activity and suppresses epimorphic tissue regeneration. [PDF]
, 2015 The control of proliferation and differentiation by tumor suppressor genes suggests that evolution of divergent tumor suppressor repertoires could influence species regenerative capacity.
Ahituv, Nadav +3 more
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Purpose Retinoblastoma (RB) is the most common pediatric ocular cancer, yet population‐based data on survival and risk factors remain limited. This study aimed to describe survival in a large national RB cohort and identify predictors of death and complications.
Samuel Sassine +14 more
wiley +1 more source