Results 21 to 30 of about 373,665 (256)
Frontiers in Genetics, 2020 In this article, we make a theoretical and in silico study for uncovering and evaluating biomarkers in colon and rectal cancer (CRC) by the dynamic network biomarker (DNB) theory.
Yanqiu Tong +4 more
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NDST4 is a novel candidate tumor suppressor gene at chromosome 4q26 and its genetic loss predicts adverse prognosis in colorectal cancer. [PDF]
PLoS ONE, 2013 BACKGROUND: Genomic deletion at tumor suppressor loci is a common genetic aberration in human cancers. The study aimed to explore candidate tumor suppressor genes at chromosome 4q25-q28.2 and to delineate novel prognostic biomarkers associated with ...
Sheng-Tai Tzeng +7 more
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Systematic Analysis of Drug Vulnerabilities Conferred by Tumor Suppressor Loss
Cell Reports, 2019 Summary: In addition to oncogene inhibition, targeting tumor suppressor deficiency could provide potential venues for precision cancer medicine. However, the full spectrum of drug vulnerability conferred by tumor suppressor loss remains unclear.
Hongyu Ding +11 more
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TUSC1, a putative tumor suppressor gene, reduces tumor cell growth in vitro and tumor growth in vivo. [PDF]
PLoS ONE, 2013 We previously reported the identification of TUSC1 (Tumor Suppressor Candidate 1), as a novel intronless gene isolated from a region of homozygous deletion at D9S126 on chromosome 9p in human lung cancer.
Zhihong Shan +5 more
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Frontiers in Immunology, 2021 Non-small-cell lung cancers (NSCLCs) are largely classified into lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC), which have different therapeutic options according to its molecular profiles and immune checkpoint expression, especially
Ahreum Kim +6 more
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Genetic Changes in Ovarian Cancer
Taiwanese Journal of Obstetrics & Gynecology, 2005 Ovarian cancer is among the most lethal of all malignancies in women. While chemotherapy is the preferred treatment modality, chemoresistance severely limits treatment success.
Kar-San Ling +4 more
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Oncogenes and Tumor Suppressor Genes [PDF]
Cold Spring Harbor Perspectives in Biology, 2010 Breast cancer progression involves multiple genetic events, which can activate dominant-acting oncogenes and disrupt the function of specific tumor suppressor genes. This article describes several key oncogene and tumor suppressor signaling networks that have been implicated in breast cancer progression.
Eva Y H P, Lee, William J, Muller
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Autophagy genes as tumor suppressors [PDF]
Current Opinion in Cell Biology, 2010 Autophagy, originally described as a universal lysosome-dependent bulk degradation of cytoplasmic components upon nutrient deprivation, has since been shown to influence diverse aspects of homeostasis and is implicated in a wide variety of pathological conditions, including cancer.
Chengyu, Liang, Jae U, Jung
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Oncogenes and Tumor-Suppressor Genes [PDF]
Environmental Health Perspectives, 1991 The functional role of oncogenes in human lung carcinogenesis has been investigated by transfer of activated oncogenes into normal cells or an immortalized bronchial epithelial cell line, BEAS-2B. Transfection of v-Ha-ras, Ki-ras, or the combination of myc and raf into BEAS-2B cells produced tumorigenic cell lines, while transfection of raf or myc ...
T A, Lehman +7 more
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Neoplasia: An International Journal for Oncology Research, 2019 Iroquois homeobox 1 (IRX1) belongs to the Iroquois homeobox family known to play an important role during embryonic development. Interestingly, however, recent studies have suggested that IRX1 also acts as a tumor suppressor.
In Hye Jung +4 more
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