Results 21 to 30 of about 359,694 (255)
Neoplasia: An International Journal for Oncology Research, 2019 Iroquois homeobox 1 (IRX1) belongs to the Iroquois homeobox family known to play an important role during embryonic development. Interestingly, however, recent studies have suggested that IRX1 also acts as a tumor suppressor.
In Hye Jung +4 more
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CREB targets define the gene expression signature of malignancies having reduced levels of the tumor suppressor tristetraprolin. [PDF]
PLoS ONE, 2014 The RNA-binding protein Tristetraprolin (TTP, ZFP36) functions as a tumor suppressor that impairs the development and disables the maintenance of MYC-driven lymphoma.
Mohammad Fallahi +3 more
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Oncogenes and Tumor Suppressor Genes [PDF]
Acta Oncologica, 1988 The artificial selection of the directly acting or acute RNA tumor viruses for high transforming ability has led to the isolation of defective retroviral genomes that have picked up, by accidental recombination, some of the important genes that influence, trigger or regulate cell division.
openaire +2 more sources
Expression of WW Domain-Containing Oxidoreductase WOX1 in Human Nervous System Tumors
Analytical Cellular Pathology, 2013 Background and ObjectiveS: We aimed to evaluate the expression levels of the tumor suppressor WOX1 in nervous system tumors and its co-expression with p53 and neurofibromatosis type 2/merlin (NF2) tumor suppressor gene products.
Ming-Fu Chiang +5 more
doaj +1 more source
Haploinsufficiency of the ESCRT Component HD-PTP Predisposes to Cancer
Cell Reports, 2016 Endosomal sorting complexes required for transport (ESCRT) drive cell surface receptor degradation resulting in attenuation of oncogenic signaling and pointing to a tumor suppressor function.
Sanaz Manteghi +11 more
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Synthetic lethal approaches to target cancers with loss of PTEN function
Genes and Diseases, 2023 Phosphatase and tensin homolog (PTEN) is a tumor suppressor gene and has a role in inhibiting the oncogenic AKT signaling pathway by dephosphorylating phosphatidylinositol 3,4,5-triphosphate (PIP3) into phosphatidylinositol 4,5-bisphosphate (PIP2).
Ayse Ertay, Rob M. Ewing, Yihua Wang
doaj +1 more source
NTRK3 is a potential tumor suppressor gene commonly inactivated by epigenetic mechanisms in colorectal cancer. [PDF]
PLoS Genetics, 2013 NTRK3 is a member of the neurotrophin receptor family and regulates cell survival. It appears to be a dependence receptor, and thus has the potential to act as an oncogene or as a tumor suppressor gene. NTRK3 is a receptor for NT-3 and when bound to NT-3
Yanxin Luo +8 more
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Dose-Response, 2013 A novel first-generation st ochastic gene ep isilencing ( STEP1 ) model is introduced for quantitatively characterizing the probability of in vitro epigenetically silencing (episilencing) specific tumor-suppressor- microRNA (miRNA ) genes by carcinogen ...
Bobby R. Scott
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Neoplasia: An International Journal for Oncology Research, 2001 Recently, loss of heterozygosity (LOH) studies suggest that more than two tumor suppressor genes lie on the short arm of chromosome 1 (1p) in neuroblastoma (NB).
Hong Wei Yang +5 more
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Correlation of primary tumor size and axillary nodal status with tumor suppressor gene p53 in breast carcinoma [PDF]
Vojnosanitetski Pregled, 2002 Correlation of standard path morphological prognostic parameters, primary tumor size and axillary nodal status with new prognostic factor in breast carcinoma: tumor suppressor gene p53 was analyzed.
Topić Brano +3 more
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